Functionalized Cochlear Implant Electrode for Intracochlear Histamine Detection via Molecularly Imprinted Polymer Coating

Tristan Putzeys*, Gideon Wackers, Oliver Jamieson, Marloes Peeters, Theodor Doll, Patrick Wagner, Michael Wübbenhorst, Nicolas Verhaert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

By coating the electrodes of a cochlear implant (CI) electrode array with a powdered form of molecularly imprinted polymer (MIP), a straightforward process to functionalize existing electrodes to selectively detect histamine is demonstrated. Detection is based on non-Faradaic impedance spectroscopy, omitting the need for a reference electrode or redox mediators, and fitting to a 5-element equivalent electronic circuit. Proof-of-concept measurements on three functionalized cochlear implants in three human cadaveric cochleae indicate a level of detection of 200 nM of histamine in albumin-based artificial perilymph following a sigmoid dose-response trend up to 10 mM. This sensitivity enables quantized and localized analysis of histamine-mediated inflammation immediately following the CI operation. The selectivity and adaptability of MIPs opens possibilities to detect a wide spectrum of inflammation markers inside the human cochlea and could be used for fast mid- or postoperative intervention to improve the medical implant's outcome.

Original languageEnglish
Article number2300714
JournalPhysica Status Solidi (A) Applications and Materials Science
Volume221
Issue number19
Early online date6 Dec 2023
DOIs
Publication statusPublished - 6 Oct 2024

Keywords

  • biosensors
  • electrical impedances
  • equivalent electronic circuits
  • inflammations
  • non-Faradaic

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