Abstract
By coating the electrodes of a cochlear implant (CI) electrode array with a powdered form of molecularly imprinted polymer (MIP), a straightforward process to functionalize existing electrodes to selectively detect histamine is demonstrated. Detection is based on non-Faradaic impedance spectroscopy, omitting the need for a reference electrode or redox mediators, and fitting to a 5-element equivalent electronic circuit. Proof-of-concept measurements on three functionalized cochlear implants in three human cadaveric cochleae indicate a level of detection of 200 nM of histamine in albumin-based artificial perilymph following a sigmoid dose-response trend up to 10 mM. This sensitivity enables quantized and localized analysis of histamine-mediated inflammation immediately following the CI operation. The selectivity and adaptability of MIPs opens possibilities to detect a wide spectrum of inflammation markers inside the human cochlea and could be used for fast mid- or postoperative intervention to improve the medical implant's outcome.
Original language | English |
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Article number | 2300714 |
Journal | Physica Status Solidi (A) Applications and Materials Science |
Volume | 221 |
Issue number | 19 |
Early online date | 6 Dec 2023 |
DOIs | |
Publication status | Published - 6 Oct 2024 |
Keywords
- biosensors
- electrical impedances
- equivalent electronic circuits
- inflammations
- non-Faradaic