Fungal heat-shock proteins in human disease

James Burnie, James P. Burnie, Tracey L. Carter, Samantha J. Hodgetts, Ruth C. Matthews

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Heat-shock proteins (hsps) have been identified as molecular chaperones conserved between microbes and man and grouped by their molecular mass and high degree of amino acid homology. This article reviews the major hsps of Saccharomyces cerevisiae, their interactions with trehalose, the effect of fermentation and the role of the heat-shock factor. Information derived from this model, as well as from Neurospora crassa and Achlya ambisexualis, helps in understanding the importance of hsps in the pathogenic fungi, Candida albicans, Cryptococcus neoformans, Aspergillus spp., Histoplasma capsulatum, Paracoccidioides brasiliensis, Trichophyton rubrum, Phycomyces blakesleeanus, Fusarium oxysporum, Coccidioides immitis and Pneumocystis jiroveci. This has been matched with proteomic and genomic information examining hsp expression in response to noxious stimuli. Fungal hsp90 has been identified as a target for immunotherapy by a genetically recombinant antibody. The concept of combining this antibody fragment with an antifungal drug for treating life-threatening fungal infection and the potential interactions with human and microbial hsp90 and nitric oxide is discussed. © 2005 Federation of European Microbiological Societies.
    Original languageEnglish
    Pages (from-to)53-88
    Number of pages35
    JournalFEMS microbiology reviews
    Volume30
    Issue number1
    DOIs
    Publication statusPublished - Jan 2006

    Keywords

    • Fungi
    • Heat-shock proteins
    • Moulds
    • Mycograb
    • Pathogenesis
    • Yeast

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