Funny current and sudden cardiac death

Filip Perde, Joseph Yanni Gerges, Dan Dermengiu, Halina Dobrzynski

Research output: Contribution to journalArticlepeer-review


HCN4 is considered the main channel involved in spontaneous depolarization of the sinus node cells, which underlies the formation of normal cardiac sinus rhythm. Structural and functional characteristics have been extensively studied, revealing the location, its synthesis and regulation. Its dysfunction causes supraventricular/ ventricular arrhythmias (some lifethreatening) and is involved in the pathogenesis of heart disease. In this study we investigated this channel expression in the sinus node from cadaveric heart with future utility to histopathological diagnosis of sudden cardiac death. We found that HCN4 is expressed at mRNA and protein level in the sinus node from cadaveric hearts and its expression correlates with expression of TBX3 (transcription factor that controls HCN4 expression).

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalRomanian Journal of Legal Medicine
Issue number2
Publication statusPublished - 2015


  • Arrhythmia
  • HCN4
  • Sinus node
  • Sudden cardiac death
  • TBX3


Dive into the research topics of 'Funny current and sudden cardiac death'. Together they form a unique fingerprint.

Cite this