Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Joseph A. Jackson, Joseph D. Turner, Mahine Kamal, Victoria Wright, Quentin Bickle, Kathryn J. Else, Mahdi Ramsan, Janette E. Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

Ex vivo monocyte cytokine responses (IL-1 β, TNF-α, IL-12p70, IL-10, TGF-β) to bacterial TLR2 and TLR4 ligands were quantified in 47 gastrointestinal (GI) nematode-exposed children in Pemba Island, Tanzania. Worminess (estimated by faecal egg counts (FEC)) had a positive relationship with pro-inflammatory TNF-α and IL-1β responsiveness to the TLR ligands. In particular, there was a strong significant relationship with TNF-α response to TLR4 ligand (LPS). There were no significant associations between regulatory responses (IL-10, TGF-β) and worminess. These results are consistent with the possibility that GI nematodes modulate innate responses and may indicate a potential mechanism for interactions between GI nematodiasis and important bystander pathogens. © 2005 Elsevier SAS. All rights reserved.
Original languageEnglish
Pages (from-to)487-492
Number of pages5
JournalMicrobes and Infection
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 2006

Keywords

  • Human
  • IL-10
  • Innate immunity
  • Monocyte
  • Nematodiasis
  • TGF-β
  • tlr2
  • tlr4
  • TNF-α

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