Gd-functionalised Au nanoparticles as targeted contrast agents in MRI: relaxivity enhancement by polyelectrolyte coating

M F Warsi, R W Adams, S B Duckett, V Chechik

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Monolayer-protected, Gd(3+)-functionalised gold nanoparticles with enhanced spin-lattice relaxivity (r(1)) were prepared; adsorption of polyelectrolytes on these materials further increased r(1) and ligand exchange with a biotin-derivatised disulfide led to a prototype avidin-targeted contrast agent.
    Original languageEnglish
    Pages (from-to)451-453
    Number of pages3
    JournalChemical Communications
    Volume46
    Issue number3
    DOIs
    Publication statusPublished - 2010

    Keywords

    • gold nanoparticles
    • microcapsules
    • dynamics
    • design
    • ligand

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