Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial

Ronald Chow; Keyue Ding; Vithusha Ganesh; Ralph M Meyer; Yvette M van der Linden; Daniel Roos; William F Hartsell; Peter Hoskin; Jackson S Y Wu; Abdenour Nabid; Manouk van Acht; Rinus Wanders; Scott Babington; William F Demas; Carolyn F Wilson; Rebecca K S Wong; Michael Brundage; Liting Zhu; Edward Chow

doi:10.1016/j.radonc.2017.10.006

Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial

Ronald Chow
, Keyue Ding
, Vithusha Ganesh
, Ralph M Meyer
, Yvette M van der Linden
, Daniel Roos
, William F Hartsell
, Peter Hoskin
, Jackson S Y Wu
, Abdenour Nabid
, Manouk van Acht
, Rinus Wanders
, Scott Babington
, William F Demas
, Carolyn F Wilson
, Rebecca K S Wong
, Michael Brundage
, Liting Zhu
, Edward Chow

Division of Cancer Sciences (L5)

Odette Cancer Centre
Leiden University Medical Center
The University of Adelaide
Central DuPage Hospital Cancer Center
Mount Vernon Hospital
University of Calgary
Centre Hospitalier Université de Sherbrooke
Erasmus MC
The Stichting Maastricht Radiation Oncology (MAASTRO) Clinic
Christchurch Hospital
Northeast Ohio Medical University
Princess Margaret Hospital
Queens University at Kingston
Juravinski Hospital and Cancer Centre
McMaster University

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation.

MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (C30) before and 2 months after re-irradiation.

RESULTS: A total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in C30 scores at 2 months.

CONCLUSION: Similar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age.

TRIAL REGISTRATION: NCT00080912; https://clinicaltrials.gov/ct2/show/NCT00080912.

Original language	English
Pages (from-to)	541-546
Number of pages	6
Journal	Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume	126
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2017.10.006
Publication status	Published - Mar 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Age Factors
Aged
Bone Neoplasms/physiopathology
Cancer Pain/etiology
Female
Humans
Male
Middle Aged
Pain Measurement
Palliative Care/methods
Patient Reported Outcome Measures
Practice Patterns, Physicians'/statistics & numerical data
Quality of Life
Re-Irradiation
Sex Factors

Research Highlights, Institutes and Platforms

Manchester Cancer Research Centre

Access to Document

10.1016/j.radonc.2017.10.006

Cite this

Chow, R., Ding, K., Ganesh, V., Meyer, R. M., van der Linden, Y. M., Roos, D., Hartsell, W. F., Hoskin, P., Wu, J. S. Y., Nabid, A., van Acht, M., Wanders, R., Babington, S., Demas, W. F., Wilson, C. F., Wong, R. K. S., Brundage, M., Zhu, L., & Chow, E. (2018). Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 126(3), 541-546. https://doi.org/10.1016/j.radonc.2017.10.006

@article{e4a263fb1d244ef9afae896c7695f59d,

title = "Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial",

abstract = "BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation.MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (C30) before and 2 months after re-irradiation.RESULTS: A total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in C30 scores at 2 months.CONCLUSION: Similar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age.TRIAL REGISTRATION: NCT00080912; https://clinicaltrials.gov/ct2/show/NCT00080912.",

keywords = "Age Factors, Aged, Bone Neoplasms/physiopathology, Cancer Pain/etiology, Female, Humans, Male, Middle Aged, Pain Measurement, Palliative Care/methods, Patient Reported Outcome Measures, Practice Patterns, Physicians'/statistics \& numerical data, Quality of Life, Re-Irradiation, Sex Factors",

author = "Ronald Chow and Keyue Ding and Vithusha Ganesh and Meyer, \{Ralph M\} and \{van der Linden\}, \{Yvette M\} and Daniel Roos and Hartsell, \{William F\} and Peter Hoskin and Wu, \{Jackson S Y\} and Abdenour Nabid and \{van Acht\}, Manouk and Rinus Wanders and Scott Babington and Demas, \{William F\} and Wilson, \{Carolyn F\} and Wong, \{Rebecca K S\} and Michael Brundage and Liting Zhu and Edward Chow",

year = "2018",

month = mar,

doi = "10.1016/j.radonc.2017.10.006",

language = "English",

volume = "126",

pages = "541--546",

journal = "Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology",

issn = "0167-8140",

publisher = "Elsevier BV",

number = "3",

}

Chow, R, Ding, K, Ganesh, V, Meyer, RM, van der Linden, YM, Roos, D, Hartsell, WF, Hoskin, P, Wu, JSY, Nabid, A, van Acht, M, Wanders, R, Babington, S, Demas, WF, Wilson, CF, Wong, RKS, Brundage, M, Zhu, L & Chow, E 2018, 'Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial', Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 126, no. 3, pp. 541-546. https://doi.org/10.1016/j.radonc.2017.10.006

Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial. / Chow, Ronald; Ding, Keyue; Ganesh, Vithusha et al.
In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 126, No. 3, 03.2018, p. 541-546.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Gender and age make no difference in the re-irradiation of painful bone metastases

T2 - A secondary analysis of the NCIC CTG SC.20 randomized trial

AU - Chow, Ronald

AU - Ding, Keyue

AU - Ganesh, Vithusha

AU - Meyer, Ralph M

AU - van der Linden, Yvette M

AU - Roos, Daniel

AU - Hartsell, William F

AU - Hoskin, Peter

AU - Wu, Jackson S Y

AU - Nabid, Abdenour

AU - van Acht, Manouk

AU - Wanders, Rinus

AU - Babington, Scott

AU - Demas, William F

AU - Wilson, Carolyn F

AU - Wong, Rebecca K S

AU - Brundage, Michael

AU - Zhu, Liting

AU - Chow, Edward

PY - 2018/3

Y1 - 2018/3

N2 - BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation.MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (C30) before and 2 months after re-irradiation.RESULTS: A total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in C30 scores at 2 months.CONCLUSION: Similar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age.TRIAL REGISTRATION: NCT00080912; https://clinicaltrials.gov/ct2/show/NCT00080912.

AB - BACKGROUND AND PURPOSE: Patient's gender and age may influence physicians in prescribing palliative radiotherapy. The purpose of this secondary analysis of the National Cancer Institute of Canada Clinical Trials Group Symptom Control Trial SC.20 was to explore the gender and age differences in pain and patient reported outcomes in cancer patients with bone metastases undergoing re-irradiation.MATERIALS AND METHODS: Response to radiation was evaluated using the International Bone Metastases Consensus Endpoint Definitions. Patients completed the Brief Pain Inventory (BPI) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (C30) before and 2 months after re-irradiation.RESULTS: A total of 847 patients were analyzed. At baseline, men had more dyspnea, and mild pain. Older patients consumed less analgesic. More women reported clinically significant improvement in mood and enjoyment of life in the BPI after radiation. Similarly, younger patients reported better improvement in enjoyment of life. There were no significant gender or age differences in overall survival, response to radiation, or in C30 scores at 2 months.CONCLUSION: Similar benefit in terms of pain relief was observed across all patient groups. Cancer patients with bone metastases should be offered palliative re-irradiation irrespective of gender or age.TRIAL REGISTRATION: NCT00080912; https://clinicaltrials.gov/ct2/show/NCT00080912.

KW - Age Factors

KW - Aged

KW - Bone Neoplasms/physiopathology

KW - Cancer Pain/etiology

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Pain Measurement

KW - Palliative Care/methods

KW - Patient Reported Outcome Measures

KW - Practice Patterns, Physicians'/statistics & numerical data

KW - Quality of Life

KW - Re-Irradiation

KW - Sex Factors

UR - https://www.scopus.com/pages/publications/85033483378

U2 - 10.1016/j.radonc.2017.10.006

DO - 10.1016/j.radonc.2017.10.006

M3 - Article

C2 - 29102263

SN - 0167-8140

VL - 126

SP - 541

EP - 546

JO - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

IS - 3

ER -

Chow R, Ding K, Ganesh V, Meyer RM, van der Linden YM, Roos D et al. Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 2018 Mar;126(3):541-546. doi: 10.1016/j.radonc.2017.10.006

Gender and age make no difference in the re-irradiation of painful bone metastases: A secondary analysis of the NCIC CTG SC.20 randomized trial

Abstract

UN SDGs

Keywords

Research Highlights, Institutes and Platforms

Access to Document

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