Gene duplication and complex circadian clocks in mammals

Paul Looby, Andrew S I Loudon

    Research output: Contribution to journalArticlepeer-review


    The circadian clock arose early in the evolution of life to enable organisms to adapt to the cycle of day and night. Recently, the extent and importance of circadian regulation of behaviour and physiology has come to be more fully realized. Core molecular cogs of circadian oscillators appear to have been largely conserved between such diverse organisms as Drosophila melanogaster and mammals. However, gene duplication events have produced multiple copies of many clock genes in mammals. Recent studies suggest that genome duplication has lead to increased circadian complexity and local tissue regulation. This has important implications for temporal regulation of behaviour via multiple clocks in the central nervous system, and also extends to the local physiology of major body organs and tissues.
    Original languageEnglish
    Pages (from-to)46-53
    Number of pages7
    JournalTrends in Genetics
    Issue number1
    Publication statusPublished - Jan 2005


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