Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling

James Bagnall, William Rowe, Nissrin Alachkar, James Roberts, Hazel England, Christopher Clark, Mark Platt, Dean Jackson, Mark Muldoon, Pawel Paszek

Research output: Contribution to journalArticlepeer-review

Abstract

This study demonstrates that transcriptional variability of the toll-like receptor signaling is constrained by mean mRNA responses through gene-specific modulation of transcriptional bursting.
Original languageEnglish
Pages (from-to)300-314.e8
JournalCell Systems
Volume11
Issue number3
DOIs
Publication statusPublished - 23 Sept 2020

Keywords

  • IL-1β
  • TNF-α
  • cellular heterogeneity
  • single-cell transcriptomics
  • stochastic gene expression
  • stochastic modeling
  • toll-like receptor
  • transcriptional bursting

Fingerprint

Dive into the research topics of 'Gene-Specific Linear Trends Constrain Transcriptional Variability of the Toll-like Receptor Signaling'. Together they form a unique fingerprint.

Cite this