Generation and analysis of interleukin-4 deficient mice

R. Kühn, K. Rajewsky, W. Müller

    Research output: Contribution to journalArticlepeer-review


    Interleukin-4 (IL-4) promotes the growth and differentiation of many hematopoietic cells in vitro; in particular, it directs the immunoglobulin (Ig) class switch to IgG1 and IgE. Mice homozygous for a mutation that inactivates the IL-4 gene were generated to test the requirement for IL-4 in vivo. In the mutant mice T and B cell development was normal, but the serum levels of IgG1 and IgE were strongly reduced. The IgG1 dominance in a T cell-dependent immune response was lost, and IgE was not detectable upon nematode infection. Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo.
    Original languageEnglish
    Pages (from-to)707-710
    Number of pages3
    Issue number5032
    Publication statusPublished - 1 Nov 1991


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