Abstract
The T-cell antigen receptor is a cell-surface molecule that participates in the immune response. In the present experiments the genes encoding the beta chain of the T-cell receptor were found to reside on the long arm of human chromosome 7 at or near band q32. Related sequences were found on the short arm of chromosome 7 in bands p15-21 in some experiments. Chromosomal rearrangements in T-cells from normal individuals and patients with ataxia telangiectasia have previously been observed at and near these map assignments for the beta-chain genes.
| Original language | English |
|---|---|
| Pages (from-to) | 582-5 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 228 |
| Issue number | 4699 |
| Publication status | Published - 3 May 1985 |
Keywords
- Animals
- Ataxia Telangiectasia
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human, 6-12 and X
- DNA
- Genes
- Humans
- Hybrid Cells
- Mice
- Nucleic Acid Hybridization
- Receptors, Antigen, T-Cell
- Journal Article
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S.