Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Bernard Keavney; Maciej Tomaszewski; Andrew Morris; et al

doi:10.1038/s41588-018-0205-x

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Bernard Keavney, Maciej Tomaszewski, Andrew Morris, et al

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Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Original language	English
Pages (from-to)	1412-1425
Number of pages	14
Journal	Nature Genetics
Volume	50
Issue number	10
Early online date	17 Sept 2018
DOIs	https://doi.org/10.1038/s41588-018-0205-x
Publication status	Published - 1 Oct 2018

Keywords

Adult
Aged
Aged, 80 and over
Blood Pressure/genetics
Cardiovascular Diseases/epidemiology
Cells, Cultured
Female
Genetic Loci
Genetic Predisposition to Disease
Genetic Testing/methods
Genetics, Population/methods
Genome-Wide Association Study
Human Umbilical Vein Endothelial Cells
Humans
Hypertension/genetics
Life Style
Male
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41588-018-0205-x

BP_NG_A47255R_ManuscriptR2_v4 (2)Accepted author manuscript, 2.53 MB
merged msAccepted author manuscript, 2.47 MB

Cite this

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abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Abstract

Keywords

UN SDGs

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