Genetic association and risk scores in a chronic obstructive pulmonary disease meta-analysis of 16,707 subjects

COPDGene Investigators, International COPD Genetics Network, National Emphysema Treatment Trial Genetics, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points, Robert Busch*, Brian D. Hobbs, Jin Zhou, Peter J Castaldi, Michael J. McGeachie, Megan E Hardin, Iwona Hawrylkiewicz, Pawel Sliwinski, Jae Joon Yim, Woo Jin Kim, Deog Kyeom Kim, Alvar Agusti, Barry J Make, James D Crapo, Peter M Calverley, Claudio F. DonnerDavid A. Lomas, Emiel Fm Wouters, Jorgen Vestbo, Ruth Tal-Singer, Per Bakke, Amund Gulsvik, Augusto A. Litonjua, David Sparrow, Peter D Pare, Robert D. Levy, Stephen I Rennard, Terri H Beaty, John E. Hokanson, Edwin K Silverman, Michael H Cho

*Corresponding author for this work

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Abstract

The heritability of chronic obstructive pulmonary disease (COPD) cannot be fully explained by recognized genetic risk factors identified as achieving genome-wide significance. In addition, the combined contribution of genetic variation to COPD risk has not been fully explored. We sought to determine: (1) whether studies of variants from previous studies of COPD or lung function in a larger sample could identify additional associated variants, particularly for severe COPD; and (2) the impact of genetic risk scores on COPD. We genotyped 3,346 single-nucleotide polymorphisms (SNPs) in 2,588 cases (1,803 severe COPD) and 1,782 control subjects from four cohorts, and performed association testing with COPD, combining these results with existing genotyping data from 6,633 cases (3,497 severe COPD) and 5,704 control subjects. In addition, we developed genetic risk scores from SNPs associated with lung function and COPD and tested their discriminatory power for COPD-related measures. We identified significant associations between SNPs near PPIC (P = 1.2831028) and PPP4R4/SERPINA1 (P = 1.0131028) and severe COPD; the latter association may be driven by recognized variants in SERPINA1. Genetic risk scores based on SNPs previously associated with COPD and lung function had a modest ability to discriminate COPD (area under the curve, z0.6), and accounted for a mean 0.9-1.9% lower forced expiratory volume in 1 second percent predicted for each additional risk allele. In a large genetic association analysis, we identified associations with severe COPD near PPIC and SERPINA1. A risk score based on combining genetic variants had modest, but significant, effects on risk of COPD and lung function.

Original languageEnglish
Pages (from-to)35-46
Number of pages12
JournalAmerican Journal of Respiratory Cell and Molecular Biology
Volume57
Issue number1
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Chronic obstructive pulmonary disease
  • Genetic epidemiology
  • Genetic risk factors; alpha-1 antitrypsin
  • Genetic risk score

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