Genetic basis of cranial cruciate ligament rupture (CCLR) in dogs

Arabella Elizabeth Gardiner Baird, Stuart D. Carter, John F. Innes, William E. Ollier, Andrea D. Short

    Research output: Contribution to journalArticlepeer-review


    Cranial Cruciate Ligament rupture (CCLR) is one of the most common forms of lameness in dogs and is analogous to rupture of the anterior cruciate ligament in humans, for which it can serve as a model. As there is a strong breed-related predisposition to CCLR in dogs, a study was undertaken to consider putative genetic components in susceptible dog breeds. A candidate gene, single nucleotide polymorphism (SNP) genotyping approach using MALDI-TOF mass spectrometry (Sequenom Ltd) was designed to investigate several CCLR-susceptible dog breeds and identify CCLR-associated genes/gene regions that may confer susceptibility or resistance. A meta-analysis was performed using the breed case/control candidate gene data to identify SNP associations that were common to the whole cohort of susceptible dogs. We identified SNPs in key genes involved in ligament strength, stability and extracellular matrix formation (COL5A1, COL5A2, COL1A1, COL3A1, COL11A1, COL24A1, FBN1, LOX, LTBP2) which were significantly associated with CCLR susceptibility across the dog breeds used in this study. These SNPs could have an involvement in CCLR due to a detrimental effect on ligament structure and strength. This is the first published candidate gene study that has revealed significant genetic associations with canine CCLR. © 2014 Informa Healthcare USA, Inc.
    Original languageEnglish
    Pages (from-to)275-281
    Number of pages6
    JournalConnective tissue research
    Issue number4
    Publication statusPublished - 2014


    • Candidate genes
    • Cranial cruciate ligament rupture
    • Dogs


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