Genetic Copy Number Variation and General Cognitive Ability

Andrew K. MacLeod; Gail Davies; Antony Payton; Albert Tenesa; Sarah E. Harris; David Liewald; Xiayi Ke; Michelle Luciano; Lorna M. Lopez; Alan J. Gow; Janie Corley; Paul Redmond; Geraldine McNeill; Andrew Pickles; William Ollier; Michael Horan; John M. Starr; Neil Pendleton; Pippa A. Thomson; David J. Porteous; Ian J. Deary

doi:10.1371/journal.pone.0037385

Genetic Copy Number Variation and General Cognitive Ability

Andrew K. MacLeod, Gail Davies, Antony Payton, Albert Tenesa, Sarah E. Harris, David Liewald, Xiayi Ke, Michelle Luciano, Lorna M. Lopez, Alan J. Gow, Janie Corley, Paul Redmond, Geraldine McNeill, Andrew Pickles, William Ollier, Michael Horan, John M. Starr, Neil Pendleton, Pippa A. Thomson, David J. PorteousIan J. Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (≥500kb), rare (

Original language	English
Article number	e37385
Journal	PLoS ONE
Volume	7
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0037385
Publication status	Published - 29 Dec 2012

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MacLeod, A. K., Davies, G., Payton, A., Tenesa, A., Harris, S. E., Liewald, D., Ke, X., Luciano, M., Lopez, L. M., Gow, A. J., Corley, J., Redmond, P., McNeill, G., Pickles, A., Ollier, W., Horan, M., Starr, J. M., Pendleton, N., Thomson, P. A., ... Deary, I. J. (2012). Genetic Copy Number Variation and General Cognitive Ability. PLoS ONE, 7(12), Article e37385. https://doi.org/10.1371/journal.pone.0037385

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abstract = "Differences in genomic structure between individuals are ubiquitous features of human genetic variation. Specific copy number variants (CNVs) have been associated with susceptibility to numerous complex psychiatric disorders, including attention-deficit-hyperactivity disorder, autism-spectrum disorders and schizophrenia. These disorders often display co-morbidity with low intelligence. Rare chromosomal deletions and duplications are associated with these disorders, so it has been suggested that these deletions or duplications may be associated with differences in intelligence. Here we investigate associations between large (≥500kb), rare (",

author = "MacLeod, {Andrew K.} and Gail Davies and Antony Payton and Albert Tenesa and Harris, {Sarah E.} and David Liewald and Xiayi Ke and Michelle Luciano and Lopez, {Lorna M.} and Gow, {Alan J.} and Janie Corley and Paul Redmond and Geraldine McNeill and Andrew Pickles and William Ollier and Michael Horan and Starr, {John M.} and Neil Pendleton and Thomson, {Pippa A.} and Porteous, {David J.} and Deary, {Ian J.}",

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MacLeod, AK, Davies, G, Payton, A, Tenesa, A, Harris, SE, Liewald, D, Ke, X, Luciano, M, Lopez, LM, Gow, AJ, Corley, J, Redmond, P, McNeill, G, Pickles, A, Ollier, W, Horan, M, Starr, JM, Pendleton, N, Thomson, PA, Porteous, DJ & Deary, IJ 2012, 'Genetic Copy Number Variation and General Cognitive Ability', PLoS ONE, vol. 7, no. 12, e37385. https://doi.org/10.1371/journal.pone.0037385

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AU - Tenesa, Albert

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AU - Liewald, David

AU - Ke, Xiayi

AU - Luciano, Michelle

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AU - Gow, Alan J.

AU - Corley, Janie

AU - Redmond, Paul

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AU - Pickles, Andrew

AU - Ollier, William

AU - Horan, Michael

AU - Starr, John M.

AU - Pendleton, Neil

AU - Thomson, Pippa A.

AU - Porteous, David J.

AU - Deary, Ian J.

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Genetic Copy Number Variation and General Cognitive Ability

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Inequalities in later life frailty and wellbeing: an interdisciplinary approach to causality: Full bid

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