Genetic determinants of serum testosterone concentrations in men

Terence O'Neill; Claes Ohlsson; Henri Wallaschofski; Kathryn L. Lunetta; Lisette Stolk; John R B Perry; Annemarie Koster; Ann Kristin Petersen; Joel Eriksson; Terho Lehtimäki; Ilpo T. Huhtaniemi; Geoffrey L. Hammond; Marcello Maggio; Andrea D. Coviello; EMAS Study Group; Luigi Ferrucci; Margit Heier; Albert Hofman; Kate L. Holliday; John Olov Jansson; Mika Kähönen; David Karasik; Magnus K. Karlsson; Douglas P. Kiel; Yongmei Liu; Östen Ljunggren; Mattias Lorentzon; Leo Pekka Lyytikäinen; Thomas Meitinger; Dan Mellström; David Melzer; Iva Miljkovic; Matthias Nauck; Maria Nilsson; Brenda Penninx; Stephen R. Pye; Ramachandran S. Vasan; Martin Reincke; Fernando Rivadeneira; Abdelouahid Tajar; Alexander Teumer; André G. Uitterlinden; Jagadish Ulloor; Jorma Viikari; Uwe Völker; Henry Völzke; H. Erich Wichmann; Tsung Sheng Wu; Wei Vivian Zhuang; Elad Ziv; Frederick C W Wu

doi:10.1371/journal.pgen.1002313

Genetic determinants of serum testosterone concentrations in men

Terence O'Neill, Claes Ohlsson, Henri Wallaschofski, Kathryn L. Lunetta, Lisette Stolk, John R B Perry, Annemarie Koster, Ann Kristin Petersen, Joel Eriksson, Terho Lehtimäki, Ilpo T. Huhtaniemi, Geoffrey L. Hammond, Marcello Maggio, Andrea D. Coviello, EMAS Study Group, Luigi Ferrucci, Margit Heier, Albert Hofman, Kate L. Holliday, John Olov JanssonMika Kähönen, David Karasik, Magnus K. Karlsson, Douglas P. Kiel, Yongmei Liu, Östen Ljunggren, Mattias Lorentzon, Leo Pekka Lyytikäinen, Thomas Meitinger, Dan Mellström, David Melzer, Iva Miljkovic, Matthias Nauck, Maria Nilsson, Brenda Penninx, Stephen R. Pye, Ramachandran S. Vasan, Martin Reincke, Fernando Rivadeneira, Abdelouahid Tajar, Alexander Teumer, André G. Uitterlinden, Jagadish Ulloor, Jorma Viikari, Uwe Völker, Henry Völzke, H. Erich Wichmann, Tsung Sheng Wu, Wei Vivian Zhuang, Elad Ziv, Frederick C W Wu

Research output: Contribution to journal › Article › peer-review

Abstract

Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as

Original language	English
Article number	e1002313
Journal	PL o S Genetics
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pgen.1002313
Publication status	Published - Oct 2011

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O'Neill, T., Ohlsson, C., Wallaschofski, H., Lunetta, K. L., Stolk, L., Perry, J. R. B., Koster, A., Petersen, A. K., Eriksson, J., Lehtimäki, T., Huhtaniemi, I. T., Hammond, G. L., Maggio, M., Coviello, A. D., EMAS Study Group, Ferrucci, L., Heier, M., Hofman, A., Holliday, K. L., ... Wu, F. C. W. (2011). Genetic determinants of serum testosterone concentrations in men. PL o S Genetics, 7(10), Article e1002313. https://doi.org/10.1371/journal.pgen.1002313

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title = "Genetic determinants of serum testosterone concentrations in men",

abstract = "Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as",

author = "Terence O'Neill and Claes Ohlsson and Henri Wallaschofski and Lunetta, {Kathryn L.} and Lisette Stolk and Perry, {John R B} and Annemarie Koster and Petersen, {Ann Kristin} and Joel Eriksson and Terho Lehtim{\"a}ki and Huhtaniemi, {Ilpo T.} and Hammond, {Geoffrey L.} and Marcello Maggio and Coviello, {Andrea D.} and {EMAS Study Group} and Luigi Ferrucci and Margit Heier and Albert Hofman and Holliday, {Kate L.} and Jansson, {John Olov} and Mika K{\"a}h{\"o}nen and David Karasik and Karlsson, {Magnus K.} and Kiel, {Douglas P.} and Yongmei Liu and {\"O}sten Ljunggren and Mattias Lorentzon and Lyytik{\"a}inen, {Leo Pekka} and Thomas Meitinger and Dan Mellstr{\"o}m and David Melzer and Iva Miljkovic and Matthias Nauck and Maria Nilsson and Brenda Penninx and Pye, {Stephen R.} and Vasan, {Ramachandran S.} and Martin Reincke and Fernando Rivadeneira and Abdelouahid Tajar and Alexander Teumer and Uitterlinden, {Andr{\'e} G.} and Jagadish Ulloor and Jorma Viikari and Uwe V{\"o}lker and Henry V{\"o}lzke and Wichmann, {H. Erich} and Wu, {Tsung Sheng} and Zhuang, {Wei Vivian} and Elad Ziv and Wu, {Frederick C W}",

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year = "2011",

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doi = "10.1371/journal.pgen.1002313",

language = "English",

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O'Neill, T, Ohlsson, C, Wallaschofski, H, Lunetta, KL, Stolk, L, Perry, JRB, Koster, A, Petersen, AK, Eriksson, J, Lehtimäki, T, Huhtaniemi, IT, Hammond, GL, Maggio, M, Coviello, AD, EMAS Study Group, Ferrucci, L, Heier, M, Hofman, A, Holliday, KL, Jansson, JO, Kähönen, M, Karasik, D, Karlsson, MK, Kiel, DP, Liu, Y, Ljunggren, Ö, Lorentzon, M, Lyytikäinen, LP, Meitinger, T, Mellström, D, Melzer, D, Miljkovic, I, Nauck, M, Nilsson, M, Penninx, B, Pye, SR, Vasan, RS, Reincke, M, Rivadeneira, F, Tajar, A, Teumer, A, Uitterlinden, AG, Ulloor, J, Viikari, J, Völker, U, Völzke, H, Wichmann, HE, Wu, TS, Zhuang, WV, Ziv, E & Wu, FCW 2011, 'Genetic determinants of serum testosterone concentrations in men', PL o S Genetics, vol. 7, no. 10, e1002313. https://doi.org/10.1371/journal.pgen.1002313

TY - JOUR

T1 - Genetic determinants of serum testosterone concentrations in men

AU - O'Neill, Terence

AU - Ohlsson, Claes

AU - Wallaschofski, Henri

AU - Lunetta, Kathryn L.

AU - Stolk, Lisette

AU - Perry, John R B

AU - Koster, Annemarie

AU - Petersen, Ann Kristin

AU - Eriksson, Joel

AU - Lehtimäki, Terho

AU - Huhtaniemi, Ilpo T.

AU - Hammond, Geoffrey L.

AU - Maggio, Marcello

AU - Coviello, Andrea D.

AU - EMAS Study Group

AU - Ferrucci, Luigi

AU - Heier, Margit

AU - Hofman, Albert

AU - Holliday, Kate L.

AU - Jansson, John Olov

AU - Kähönen, Mika

AU - Karasik, David

AU - Karlsson, Magnus K.

AU - Kiel, Douglas P.

AU - Liu, Yongmei

AU - Ljunggren, Östen

AU - Lorentzon, Mattias

AU - Lyytikäinen, Leo Pekka

AU - Meitinger, Thomas

AU - Mellström, Dan

AU - Melzer, David

AU - Miljkovic, Iva

AU - Nauck, Matthias

AU - Nilsson, Maria

AU - Penninx, Brenda

AU - Pye, Stephen R.

AU - Vasan, Ramachandran S.

AU - Reincke, Martin

AU - Rivadeneira, Fernando

AU - Tajar, Abdelouahid

AU - Teumer, Alexander

AU - Uitterlinden, André G.

AU - Ulloor, Jagadish

AU - Viikari, Jorma

AU - Völker, Uwe

AU - Völzke, Henry

AU - Wichmann, H. Erich

AU - Wu, Tsung Sheng

AU - Zhuang, Wei Vivian

AU - Ziv, Elad

AU - Wu, Frederick C W

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PY - 2011/10

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N2 - Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as

AB - Testosterone concentrations in men are associated with cardiovascular morbidity, osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of serum testosterone's high heritability, we performed a meta-analysis of genome-wide association data in 8,938 men from seven cohorts and followed up the genome-wide significant findings in one in silico (n = 871) and two de novo replication cohorts (n = 4,620) to identify genetic loci significantly associated with serum testosterone concentration in men. All these loci were also associated with low serum testosterone concentration defined as

U2 - 10.1371/journal.pgen.1002313

DO - 10.1371/journal.pgen.1002313

M3 - Article

C2 - 21998597

SN - 1553-7390

VL - 7

JO - PL o S Genetics

JF - PL o S Genetics

IS - 10

M1 - e1002313

ER -

Genetic determinants of serum testosterone concentrations in men

Abstract

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