Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Sheila A. Fisher; Mark Tremelling; Carl A. Anderson; Rhian Gwilliam; Suzannah Bumpstead; Natalie J. Prescott; Elaine R. Nimmo; Dunecan Massey; Carlo Berzuini; Christopher Johnson; Jeffrey C. Barrett; Fraser R. Cummings; Hazel Drummond; Charlie W. Lees; Clive M. Onnie; Catherine E. Hanson; Katarzyna Blaszczyk; Mike Inouye; Philip Ewels; Radhi Ravindrarajah; Andrew Keniry; Sarah Hunt; Martyn Carter; Nick Watkins; Willem Ouwehand; Cathryn M. Lewis; Lon Cardon; Alan Lobo; Alastair Forbes; Jeremy Sanderson; Derek P. Jewell; John C. Mansfield; Panos Deloukas; Christopher G. Mathew; Miles Parkes; Jack Satsangi

doi:10.1038/ng.145

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Sheila A. Fisher, Mark Tremelling, Carl A. Anderson, Rhian Gwilliam, Suzannah Bumpstead, Natalie J. Prescott, Elaine R. Nimmo, Dunecan Massey, Carlo Berzuini, Christopher Johnson, Jeffrey C. Barrett, Fraser R. Cummings, Hazel Drummond, Charlie W. Lees, Clive M. Onnie, Catherine E. Hanson, Katarzyna Blaszczyk, Mike Inouye, Philip Ewels, Radhi RavindrarajahAndrew Keniry, Sarah Hunt, Martyn Carter, Nick Watkins, Willem Ouwehand, Cathryn M. Lewis, Lon Cardon, Alan Lobo, Alastair Forbes, Jeremy Sanderson, Derek P. Jewell, John C. Mansfield, Panos Deloukas, Christopher G. Mathew, Miles Parkes, Jack Satsangi

Research output: Contribution to journal › Article › peer-review

Abstract

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases. © 2008 Nature Publishing Group.

Original language	English
Pages (from-to)	710-712
Number of pages	2
Journal	Nature Genetics
Volume	40
Issue number	6
DOIs	https://doi.org/10.1038/ng.145
Publication status	Published - Jun 2008

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Fisher, S. A., Tremelling, M., Anderson, C. A., Gwilliam, R., Bumpstead, S., Prescott, N. J., Nimmo, E. R., Massey, D., Berzuini, C., Johnson, C., Barrett, J. C., Cummings, F. R., Drummond, H., Lees, C. W., Onnie, C. M., Hanson, C. E., Blaszczyk, K., Inouye, M., Ewels, P., ... Satsangi, J. (2008). Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nature Genetics, 40(6), 710-712. https://doi.org/10.1038/ng.145

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title = "Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease",

abstract = "We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases. {\textcopyright} 2008 Nature Publishing Group.",

author = "Fisher, {Sheila A.} and Mark Tremelling and Anderson, {Carl A.} and Rhian Gwilliam and Suzannah Bumpstead and Prescott, {Natalie J.} and Nimmo, {Elaine R.} and Dunecan Massey and Carlo Berzuini and Christopher Johnson and Barrett, {Jeffrey C.} and Cummings, {Fraser R.} and Hazel Drummond and Lees, {Charlie W.} and Onnie, {Clive M.} and Hanson, {Catherine E.} and Katarzyna Blaszczyk and Mike Inouye and Philip Ewels and Radhi Ravindrarajah and Andrew Keniry and Sarah Hunt and Martyn Carter and Nick Watkins and Willem Ouwehand and Lewis, {Cathryn M.} and Lon Cardon and Alan Lobo and Alastair Forbes and Jeremy Sanderson and Jewell, {Derek P.} and Mansfield, {John C.} and Panos Deloukas and Mathew, {Christopher G.} and Miles Parkes and Jack Satsangi",

note = "Ulcerative colitis and Crohn's disease genetics: more similar than we thought? [Gastroenterology. 2008] New susceptibility genes for ulcerative colitis.",

year = "2008",

month = jun,

doi = "10.1038/ng.145",

language = "English",

volume = "40",

pages = "710--712",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Springer Nature",

number = "6",

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Fisher, SA, Tremelling, M, Anderson, CA, Gwilliam, R, Bumpstead, S, Prescott, NJ, Nimmo, ER, Massey, D, Berzuini, C, Johnson, C, Barrett, JC, Cummings, FR, Drummond, H, Lees, CW, Onnie, CM, Hanson, CE, Blaszczyk, K, Inouye, M, Ewels, P, Ravindrarajah, R, Keniry, A, Hunt, S, Carter, M, Watkins, N, Ouwehand, W, Lewis, CM, Cardon, L, Lobo, A, Forbes, A, Sanderson, J, Jewell, DP, Mansfield, JC, Deloukas, P, Mathew, CG, Parkes, M & Satsangi, J 2008, 'Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease', Nature Genetics, vol. 40, no. 6, pp. 710-712. https://doi.org/10.1038/ng.145

TY - JOUR

T1 - Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

AU - Fisher, Sheila A.

AU - Tremelling, Mark

AU - Anderson, Carl A.

AU - Gwilliam, Rhian

AU - Bumpstead, Suzannah

AU - Prescott, Natalie J.

AU - Nimmo, Elaine R.

AU - Massey, Dunecan

AU - Berzuini, Carlo

AU - Johnson, Christopher

AU - Barrett, Jeffrey C.

AU - Cummings, Fraser R.

AU - Drummond, Hazel

AU - Lees, Charlie W.

AU - Onnie, Clive M.

AU - Hanson, Catherine E.

AU - Blaszczyk, Katarzyna

AU - Inouye, Mike

AU - Ewels, Philip

AU - Ravindrarajah, Radhi

AU - Keniry, Andrew

AU - Hunt, Sarah

AU - Carter, Martyn

AU - Watkins, Nick

AU - Ouwehand, Willem

AU - Lewis, Cathryn M.

AU - Cardon, Lon

AU - Lobo, Alan

AU - Forbes, Alastair

AU - Sanderson, Jeremy

AU - Jewell, Derek P.

AU - Mansfield, John C.

AU - Deloukas, Panos

AU - Mathew, Christopher G.

AU - Parkes, Miles

AU - Satsangi, Jack

N1 - Ulcerative colitis and Crohn's disease genetics: more similar than we thought? [Gastroenterology. 2008] New susceptibility genes for ulcerative colitis.

PY - 2008/6

Y1 - 2008/6

N2 - We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases. © 2008 Nature Publishing Group.

AB - We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases. © 2008 Nature Publishing Group.

U2 - 10.1038/ng.145

DO - 10.1038/ng.145

M3 - Article

SN - 1061-4036

VL - 40

SP - 710

EP - 712

JO - Nature Genetics

JF - Nature Genetics

IS - 6

ER -

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Abstract

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