GENETIC DIFFERENCES CAN BE DEMONSTRATED BETWEEN POLYMYOSITIS AND DERMATOMYOSITIS USING HLA-DRB1 AND DQB1 GENOTYPING

H Chinoy; F Salway; W Thomson; AJ Silman; WER Ollier; RG Cooper

GENETIC DIFFERENCES CAN BE DEMONSTRATED BETWEEN POLYMYOSITIS AND DERMATOMYOSITIS USING HLA-DRB1 AND DQB1 GENOTYPING

H Chinoy, F Salway, W Thomson, AJ Silman, WER Ollier, RG Cooper

Research output: Contribution to conference › Other

Abstract

Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 244 cases.AIMS: 1. To evaluate the role of HLA-DRB1 & DQB1 genotyping in PM, DM and PM/overlap disease2. To determine the genetic differences of PM and DM in a UK White Caucasian population METHODS: 244 adult UK white patients; PM, n=98 (28 males, 49.7 ± 14.7 years), DM, n=85 (26 males, 45.4 ± 14.7 years), PM/overlap, n=61 (12 males, 47.4 ± 11.5 years), with definite myositis, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with a randomly selected, ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p

Original language	English
Pages	9-9
Publication status	Published - Apr 2003
Event	British Society for Rheumatology - Edinburgh Duration: 1 Jan 1824 → …

Conference

Conference	British Society for Rheumatology
City	Edinburgh
Period	1/01/24 → …

Cite this

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title = "GENETIC DIFFERENCES CAN BE DEMONSTRATED BETWEEN POLYMYOSITIS AND DERMATOMYOSITIS USING HLA-DRB1 AND DQB1 GENOTYPING",

abstract = "Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 244 cases.AIMS: 1. To evaluate the role of HLA-DRB1 & DQB1 genotyping in PM, DM and PM/overlap disease2. To determine the genetic differences of PM and DM in a UK White Caucasian population METHODS: 244 adult UK white patients; PM, n=98 (28 males, 49.7 ± 14.7 years), DM, n=85 (26 males, 45.4 ± 14.7 years), PM/overlap, n=61 (12 males, 47.4 ± 11.5 years), with definite myositis, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with a randomly selected, ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p",

author = "H Chinoy and F Salway and W Thomson and AJ Silman and WER Ollier and RG Cooper",

year = "2003",

month = apr,

language = "English",

pages = "9--9",

note = "British Society for Rheumatology ; Conference date: 01-01-1824",

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TY - CONF

T1 - GENETIC DIFFERENCES CAN BE DEMONSTRATED BETWEEN POLYMYOSITIS AND DERMATOMYOSITIS USING HLA-DRB1 AND DQB1 GENOTYPING

AU - Chinoy, H

AU - Salway, F

AU - Thomson, W

AU - Silman, AJ

AU - Ollier, WER

AU - Cooper, RG

PY - 2003/4

Y1 - 2003/4

N2 - Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 244 cases.AIMS: 1. To evaluate the role of HLA-DRB1 & DQB1 genotyping in PM, DM and PM/overlap disease2. To determine the genetic differences of PM and DM in a UK White Caucasian population METHODS: 244 adult UK white patients; PM, n=98 (28 males, 49.7 ± 14.7 years), DM, n=85 (26 males, 45.4 ± 14.7 years), PM/overlap, n=61 (12 males, 47.4 ± 11.5 years), with definite myositis, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with a randomly selected, ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p

AB - Various studies have confirmed that HLA-DRB1*03 is a risk factor for idiopathic inflammatory myositis, but have failed to elucidate any significant genetic differences between PM and DM. Through the UK Myositis Immunogenetic Collaboration, we have collected DNA phenotype data on 244 cases.AIMS: 1. To evaluate the role of HLA-DRB1 & DQB1 genotyping in PM, DM and PM/overlap disease2. To determine the genetic differences of PM and DM in a UK White Caucasian population METHODS: 244 adult UK white patients; PM, n=98 (28 males, 49.7 ± 14.7 years), DM, n=85 (26 males, 45.4 ± 14.7 years), PM/overlap, n=61 (12 males, 47.4 ± 11.5 years), with definite myositis, according to the Tanimoto criteria (J Rheumatol 1995, 22:668-674), were compared with a randomly selected, ethnically matched control group (n=537). DNA was amplified by the polymerase chain reaction (PCR) and HLA-DRB1 genotyping was performed using the Dynal RELITM SSO test.RESULTS: There was an overall difference in the HLA-DRB1 global phenotype frequencies between the whole myositis population and controls (p

M3 - Other

SP - 9

EP - 9

T2 - British Society for Rheumatology

Y2 - 1 January 1824

ER -

GENETIC DIFFERENCES CAN BE DEMONSTRATED BETWEEN POLYMYOSITIS AND DERMATOMYOSITIS USING HLA-DRB1 AND DQB1 GENOTYPING

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