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Abstract
Background. Gastro-oesophageal reflux disease (GORD) is associate with greater risk of idiopathic pulmonary fibrosis (IPF) in observational studies, but results are limited by confounding. We used multivariable Mendelian randomisation to examine their causal relationship, adjusting for BMI.
Methods. We selected genetic instruments for GORD from a genome-wide associations studies of 80,265 cases and 305,011 controls. Genetic association data for IPF were obtained from 2,668 cases and 8,591 control, and from 694,649 individuals for BMI. We used the inverse-variance weighted method and a series of sensitivity analyses including weak instrument robust methods.
Results. Although genetic liability to GORD increased IPF risk (OR 1.58; 95%CI 1.10-2.25), this was attenuated to include the null after adjusting for BMI (OR 1.14; 95%CI 0.85-1.52).
Conclusion. Intervention on GORD alone is unlikely to reduce risk of IPF, whereas reducing obesity may be a better approach.
Methods. We selected genetic instruments for GORD from a genome-wide associations studies of 80,265 cases and 305,011 controls. Genetic association data for IPF were obtained from 2,668 cases and 8,591 control, and from 694,649 individuals for BMI. We used the inverse-variance weighted method and a series of sensitivity analyses including weak instrument robust methods.
Results. Although genetic liability to GORD increased IPF risk (OR 1.58; 95%CI 1.10-2.25), this was attenuated to include the null after adjusting for BMI (OR 1.14; 95%CI 0.85-1.52).
Conclusion. Intervention on GORD alone is unlikely to reduce risk of IPF, whereas reducing obesity may be a better approach.
| Original language | English |
|---|---|
| Journal | Respiratory Investigation |
| Publication status | Accepted/In press - 17 Feb 2023 |
Keywords
- Gastro-oesophageal reflux disease
- idiopathic pulmonary fibrosis
- obesity
- BMI
- Mendelian randomisation
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Dive into the research topics of 'Genetic liability to gastro-oesophageal reflux disease, obesity and risk of idiopathic pulmonary fibrosis'. Together they form a unique fingerprint.Projects
- 1 Finished
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Centre for Epidemiology Versus Arthritis.
Dixon, W. (PI), Bruce, I. (CoI), Felson, D. (CoI), Hyrich, K. (CoI), Lunt, M. (CoI), Mcbeth, J. (CoI), Mcdonagh, J. (CoI), O'Neill, T. (CoI), Sergeant, J. (CoI), Verstappen, S. (CoI) & Serafimova, I. (Support team)
1/08/18 → 14/03/24
Project: Research