TY - JOUR
T1 - Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
AU - Viatte, Sebastien
AU - Plant, Darren
AU - Bowes, John
AU - Lunt, Mark
AU - Eyre, Stephen
AU - Barton, Anne
AU - Worthington, Jane
PY - 2012/12
Y1 - 2012/12
N2 - Introduction: There are now over 30 confirmed loci predisposing to rheumatoid arthritis (RA). Studies have been largely undertaken in patients with anticyclic citrullinated peptide (anti-CCP) positive RA, and some genetic associations appear stronger in this subgroup than in anti-CCP negative disease, although few studies have had adequate power to address the question. The authors therefore investigated confirmed RA susceptibility loci in a large cohort of anti-CCP negative RA subjects. Methods: RA patients and controls, with serological and genetic data, were available from UK Caucasian patients (n=4068 anti-CCP positive, 2040 anti-CCP negative RA) and 13,009 healthy controls. HLA-DRB1 genotypes and 36 single nucleotide polymorphisms were tested for association between controls and anti-CCP positive or negative RA. Results: The shared epitope (SE) showed a strong association with anti-CCP positive and negative RA, although the effect size was significantly lower in the latter (effect size ratio=3.18, p
AB - Introduction: There are now over 30 confirmed loci predisposing to rheumatoid arthritis (RA). Studies have been largely undertaken in patients with anticyclic citrullinated peptide (anti-CCP) positive RA, and some genetic associations appear stronger in this subgroup than in anti-CCP negative disease, although few studies have had adequate power to address the question. The authors therefore investigated confirmed RA susceptibility loci in a large cohort of anti-CCP negative RA subjects. Methods: RA patients and controls, with serological and genetic data, were available from UK Caucasian patients (n=4068 anti-CCP positive, 2040 anti-CCP negative RA) and 13,009 healthy controls. HLA-DRB1 genotypes and 36 single nucleotide polymorphisms were tested for association between controls and anti-CCP positive or negative RA. Results: The shared epitope (SE) showed a strong association with anti-CCP positive and negative RA, although the effect size was significantly lower in the latter (effect size ratio=3.18, p
U2 - 10.1136/annrheumdis-2011-201225
DO - 10.1136/annrheumdis-2011-201225
M3 - Article
C2 - 22661644
SN - 0003-4967
VL - 71
SP - 1984
EP - 1990
JO - Annals of the rheumatic diseases
JF - Annals of the rheumatic diseases
IS - 12
ER -