Genetic studies of body mass index yield new insights for obesity biology.

Adam E Locke, Bratati Kahali, Sonja I Berndt, Anne E Justice, Tune H Pers, Felix R Day, Corey Powell, Jian Yang, Damien C Croteau-Chonka, Tonu Esko, Joshua C Randall, Thomas W Winkler, Andrew R Wood, Tsegaselassie Workalemahu, Jessica D Faul, Rudolf Fehrmann, Juha Karjalainen, Denise Anderson, Marian Beekman, Guohong DengVaneet Lotay, Irene Mateo Leach, Carolina Medina-Gomez, Dorota Pasko, Sonali Pechlivanis, Marjolein J Peters, Yun Ju Sung, Sander W van der Laan, Jessica van Setten, Jana V Van Vliet-Ostaptchouk, Zhaoming Wang, Gillian M Arscott, Antony P Attwood, Isabelita N Bas, Claire Bellis, Amanda J Bennett, Christian Berne, Roza Blagieva, Matthias Blüher, Stefan Böhringer, Yvonne Böttcher, Ida H Caspersen, E Warwick Daw, Anton J M de Craen, Graciela Delgado, Niina Eklund, Karol Estrada, Elodie Eury, Vilmantas Giedraitis, Alain Golay, Hans-Jörgen Grabe, Tanja B Grammer, Jürgen Gräßler, Henrik Grönberg, Gaëlle Gusto, Goran Hallmans, Catharina A Hartman, Maija Hassinen, Nancy L Heard-Costa, Quinta Helmer, Oddgeir Holmen, Jennifer Jolley, Thorhildur Juliusdottir, Leena Kinnunen, Markku Koskenvuo, Claudia Lamina, Peter Lichtner, Ken Sin Lo, Stéphane Lobbens, Roberto Lorbeer, Yingchang Lu, Stela McLachlan, Cristina Menni, Sigrun Merger, Lili Milani, Alireza Moayyeri, Keri L Monda, Antonella Mulas, Gabriele Müller, Arthur W Musk, Markus M Nöthen, Stefan Pilz, Frida Renstrom, Janina S Ried, Stephan Ripke, Lynda M Rose, Salome Scholtens, William R Scott, Thomas Seufferlein, Jianxin Shi, Albert Vernon Smith, Joanna Smolonska, Alice V Stanton, Valgerdur Steinthorsdottir, Johan Sundström, Morris A Swertz, Jonathan P Tyrer, Hae-Won Uh, Liesbeth Vandenput, Frank C Verhulst, Sita H Vermeulen, Judith M Vonk, Helen R Warren, Mary K Wojczynski, Qunyuan Zhang, Murim Choi, Zari Dastani, Alexander W Drong, Jesper R Gådin, Ali G Gharavi, Michael E Goddard, Robert E Handsaker, Jinyan Huang, Fredrik Karpe, Krzysztof Kiryluk, Michiaki Kubo, Liming Liang, Richard P Lifton, Baoshan Ma, Amy J McKnight, Miriam F Moffatt, George Nicholson, Yukinori Okada, Rajkumar Dorajoo, Eva Reinmaa, Atsushi Takahashi, Toshihiro Tanaka, Ferdinand M Van't Hooft, Anna A E Vinkhuyzen, Harm-Jan Westra, John Beilby, John Blangero, Daniele Cusi, Hester M den Ruijter, Raimund Erbel, Stephan B Felix, Ele Ferrannini, Oscar H Franco, Ron T Gansevoort, Pablo V Gejman, Omri Gottesman, Andrew T Hattersley, Kevin B Jacobs, Karl-Heinz Jöckel, Berit Johansen, Pekka Jousilahti, Lambertus A Kiemeney, Paul Knekt, Aldi T Kraja, Loic Le Marchand, Valeriya Lyssenko, Satu Männistö, André Marette, Frans L Moll, Claes Ohlsson, Pamela A F Madden, Gerard Pasterkamp, Lu Qi, Tuomo Rankinen, D C Rao, Treva K Rice, John D Rioux, Mark A Sarzynski, Peter Sever, Konstantin Strauch, Angelo Tremblay, Marie-Claude Vohl, Jacqueline C Witteman, Folkert W Asselbergs, Erwin P Bottinger, Claude Bouchard, Stéphane Cauchi, Paul I W de Bakker, Robert C Kaplan, Susanne Moebus, Louis Pérusse, P Eline Slagboom, Mark Walker, David R Weir, Pieter Zanen, André Scherag, Elizabeth K Speliotes, Panos Deloukas (Collaborator), Stavroula Kanoni (Collaborator), Christina Willenborg (Collaborator), Martin Farrall (Collaborator), Themistocles L Assimes (Collaborator), John R Thompson (Collaborator), Erik Ingelsson (Collaborator), Danish Saleheen (Collaborator), Jeanette Erdmann (Collaborator), Benjamin A Goldstein (Collaborator), Kathleen Stirrups (Collaborator), Inke R König (Collaborator), Jean-Baptiste Cazier (Collaborator), Åsa Johansson (Collaborator), Alistair S Hall (Collaborator), Jong-Young Lee (Collaborator), Cristen J Willer (Collaborator), John C Chambers (Collaborator), Tõnu Esko (Collaborator), Lasse Folkersen (Collaborator), Anuj Goel (Collaborator), Elin Grundberg (Collaborator), Aki S Havulinna (Collaborator), Weang K Ho (Collaborator), Jemma C Hopewell (Collaborator), Niclas Eriksson (Collaborator), Marcus E Kleber (Collaborator), Kati Kristiansson (Collaborator), Per Lundmark (Collaborator), Leo-Pekka Lyytikäinen (Collaborator), Suzanne Rafelt (Collaborator), Dmitry Shungin (Collaborator), Rona J Strawbridge (Collaborator), Gudmar Thorleifsson (Collaborator), Emmi Tikkanen (Collaborator), Natalie Van Zuydam (Collaborator), Benjamin F Voight (Collaborator), Lindsay L Waite (Collaborator), Weihua Zhang (Collaborator), Andreas Ziegler (Collaborator), Devin Absher (Collaborator), David Altshuler (Collaborator), Anthony J Balmforth (Collaborator), Inês Barroso (Collaborator), Peter S Braund (Collaborator), Christof Burgdorf (Collaborator), Simone Claudi-Boehm (Collaborator), David Cox (Collaborator), Maria Dimitriou (Collaborator), Ron Do (Collaborator), NourEddine El Mokhtari (Collaborator), Per Eriksson (Collaborator), Krista Fischer (Collaborator), Pierre Fontanillas (Collaborator), Anders Franco-Cereceda (Collaborator), Bruna Gigante (Collaborator), Leif Groop (Collaborator), Stefan Gustafsson (Collaborator), Jörg Hager (Collaborator), Göran Hallmans (Collaborator), Bok-Ghee Han (Collaborator), Sarah E Hunt (Collaborator), Hyun M Kang (Collaborator), Thomas Illig (Collaborator), Thorsten Kessler (Collaborator), Joshua W Knowles (Collaborator), Genovefa Kolovou (Collaborator), Johanna Kuusisto (Collaborator), Claudia Langenberg (Collaborator), Cordelia Langford (Collaborator), Karin Leander (Collaborator), Marja-Liisa Lokki (Collaborator), Anders Lundmark (Collaborator), Mark I McCarthy (Collaborator), Christa Meisinger (Collaborator), Olle Melander (Collaborator), Evelin Mihailov (Collaborator), Seraya Maouche (Collaborator), Andrew D Morris (Collaborator), Martina Müller-Nurasyid (Collaborator), Kjell Nikus (Collaborator), John F Peden (Collaborator), N William Rayner (Collaborator), Asif Rasheed (Collaborator), Silke Rosinger (Collaborator), Diana Rubin (Collaborator), Moritz P Rumpf (Collaborator), Arne Schäfer (Collaborator), Mohan Sivananthan (Collaborator), Ci Song (Collaborator), Alexandre F R Stewart (Collaborator), Sian-Tsung Tan (Collaborator), Gudmundur Thorgeirsson (Collaborator), C Ellen van der Schoot (Collaborator), Peter J Wagner (Collaborator), George A Wells (Collaborator), Philipp S Wild (Collaborator), Yang Tsun-Po (Collaborator), Philippe Amouyel (Collaborator), Dominique Arveiler (Collaborator), Hanneke Basart (Collaborator), Michael Boehnke (Collaborator), Eric Boerwinkle (Collaborator), Paolo Brambilla (Collaborator), Francois Cambien (Collaborator), Adrienne L Cupples (Collaborator), Ulf de Faire (Collaborator), Abbas Dehghan (Collaborator), Patrick Diemert (Collaborator), Stephen E Epstein (Collaborator), Alun Evans (Collaborator), Marco M Ferrario (Collaborator), Jean Ferrières (Collaborator), Dominique Gauguier (Collaborator), Alan S Go (Collaborator), Villi Gudnason (Collaborator), Stanley L Hazen (Collaborator), Hilma Holm (Collaborator), Carlos Iribarren (Collaborator), Yangsoo Jang (Collaborator), Mika Kähönen (Collaborator), Frank Kee (Collaborator), Hyo-Soo Kim (Collaborator), Norman Klopp (Collaborator), Wolfgang Koenig (Collaborator), Wolfgang Kratzer (Collaborator), Kari Kuulasmaa (Collaborator), Markku Laakso (Collaborator), Reijo Laaksonen (Collaborator), Ji-Young Lee (Collaborator), Lars Lind (Collaborator), Sarah Parish (Collaborator), Jeong E Park (Collaborator), Nancy L Pedersen (Collaborator), Annette Peters (Collaborator), Thomas Quertermous (Collaborator), Daniel J Rader (Collaborator), Veikko Salomaa (Collaborator), Eric Schadt (Collaborator), Svati H Shah (Collaborator), Juha Sinisalo (Collaborator), Klaus Stark (Collaborator), Kari Stefansson (Collaborator), David-Alexandre Trégouët (Collaborator), Jarmo Virtamo (Collaborator), Lars Wallentin (Collaborator), Nicholas Wareham (Collaborator), Martina E Zimmermann (Collaborator), Markku S Nieminen (Collaborator), Christian Hengstenberg (Collaborator), Manjinder S Sandhu (Collaborator), Tomi Pastinen (Collaborator), Ann-Christine Syvänen (Collaborator), G Kees Hovingh (Collaborator), George Dedoussis (Collaborator), Paul W Franks (Collaborator), Terho Lehtimäki (Collaborator), Andres Metspalu (Collaborator), Pierre A Zalloua (Collaborator), Agneta Siegbahn (Collaborator), Stefan Schreiber (Collaborator), Samuli Ripatti (Collaborator), Stefan S Blankenberg (Collaborator), Markus Perola (Collaborator), Robert Clarke (Collaborator), Bernhard O Boehm (Collaborator), Winfried März (Collaborator), Rory Collins (Collaborator), Sekar Kathiresan (Collaborator), Anders Hamsten (Collaborator), Jaspal S Kooner (Collaborator), Unnur Thorsteinsdottir (Collaborator), John Danesh (Collaborator), Robert Roberts (Collaborator), Hugh Watkins (Collaborator), Heribert Schunkert (Collaborator), Cristian Pattaro (Collaborator), Anna Köttgen (Collaborator), Alexander Teumer (Collaborator), Maija Garnaas (Collaborator), Carsten A Böger (Collaborator), Christian Fuchsberger (Collaborator), Matthias Olden (Collaborator), Ming-Huei Chen (Collaborator), Adrienne Tin (Collaborator), Daniel Taliun (Collaborator), Man Li (Collaborator), Xiaoyi Gao (Collaborator), Mathias Gorski (Collaborator), Qiong Yang (Collaborator), Claudia Hundertmark (Collaborator), Meredith C Foster (Collaborator), Conall M O'Seaghdha (Collaborator), Nicole Glazer (Collaborator), Aaron Isaacs (Collaborator), Ching-Ti Liu (Collaborator), Jeffrey R O'Connell (Collaborator), Maksim Struchalin (Collaborator), Toshiko Tanaka (Collaborator), Guo Li (Collaborator), Hinco J Gierman (Collaborator), Mary Feitosa (Collaborator), Shih-Jen Hwang (Collaborator), Elizabeth J Atkinson (Collaborator), Kurt Lohman (Collaborator), Marilyn C Cornelis (Collaborator), Anke Tönjes (Collaborator), Vincent Chouraki (Collaborator), Elizabeth G Holliday (Collaborator), Rossella Sorice (Collaborator), Zoltan Kutalik (Collaborator), Harshal Deshmukh (Collaborator), Sheila Ulivi (Collaborator), Audrey Y Chu (Collaborator), Federico Murgia (Collaborator), Stella Trompet (Collaborator), Medea Imboden (Collaborator), Barbara Kollerits (Collaborator), Giorgio Pistis (Collaborator), Tamara B Harris (Collaborator), Thor Aspelund (Collaborator), Gudny Eiriksdottir (Collaborator), Braxton D Mitchell (Collaborator), Helena Schmidt (Collaborator), Margherita Cavalieri (Collaborator), Madhumathi Rao (Collaborator), Frank B Hu (Collaborator), Ayse Demirkan (Collaborator), Ben A Oostra (Collaborator), Mariza de Andrade (Collaborator), Stephen T Turner (Collaborator), Jingzhong Ding (Collaborator), Jeanette S Andrews (Collaborator), Barry I Freedman (Collaborator), Angela Döring (Collaborator), H-Erich Wichmann (Collaborator), Ivana Kolcic (Collaborator), Tatijana Zemunik (Collaborator), Mladen Boban (Collaborator), Cosetta Minelli (Collaborator), Heather E Wheeler (Collaborator), Wilmar Igl (Collaborator), Ghazal Zaboli (Collaborator), Sarah H Wild (Collaborator), Alan F Wright (Collaborator), Harry Campbell (Collaborator), David Ellinghaus (Collaborator), Ute Nöthlings (Collaborator), Gunnar Jacobs (Collaborator), Reiner Biffar (Collaborator), Karlhans Endlich (Collaborator), Florian Ernst (Collaborator), Georg Homuth (Collaborator), Heyo K Kroemer (Collaborator), Matthias Nauck (Collaborator), Sylvia Stracke (Collaborator), Uwe Völker (Collaborator), Henry Völzke (Collaborator), Peter Kovacs (Collaborator), Michael Stumvoll (Collaborator), Reedik Mägi (Collaborator), Albert Hofman (Collaborator), Andre G Uitterlinden (Collaborator), Fernando Rivadeneira (Collaborator), Ozren Polasek (Collaborator), Nick Hastie (Collaborator), Veronique Vitart (Collaborator), Catherine Helmer (Collaborator), Jie Jin Wang (Collaborator), Daniela Ruggiero (Collaborator), Sven Bergmann (Collaborator), Jorma Viikari (Collaborator), Tiit Nikopensius (Collaborator), Michael Province (Collaborator), Shamika Ketkar (Collaborator), Helen Colhoun (Collaborator), Alex Doney (Collaborator), Antonietta Robino (Collaborator), Franco Giulianini (Collaborator), Bernhard K Krämer (Collaborator), Laura Portas (Collaborator), Ian Ford (Collaborator), Brendan M Buckley (Collaborator), Martin Adam (Collaborator), Gian-Andri Thun (Collaborator), Bernhard Paulweber (Collaborator), Margot Haun (Collaborator), Cinzia Sala (Collaborator), Marie Metzger (Collaborator), Paul Mitchell (Collaborator), Marina Ciullo (Collaborator), Stuart K Kim (Collaborator), Peter Vollenweider (Collaborator), Olli Raitakari (Collaborator), Colin Palmer (Collaborator), Paolo Gasparini (Collaborator), Mario Pirastu (Collaborator), J Wouter Jukema (Collaborator), Nicole M Probst-Hensch (Collaborator), Florian Kronenberg (Collaborator), Daniela Toniolo (Collaborator), Vilmundur Gudnason (Collaborator), Alan R Shuldiner (Collaborator), Josef Coresh (Collaborator), Reinhold Schmidt (Collaborator), Luigi Ferrucci (Collaborator), Cornelia M van Duijn (Collaborator), Ingrid Borecki (Collaborator), Yongmei Liu (Collaborator), Igor Rudan (Collaborator), Ulf Gyllensten (Collaborator), James F Wilson (Collaborator), Andre Franke (Collaborator), Peter P Pramstaller (Collaborator), Rainer Rettig (Collaborator), Inga Prokopenko (Collaborator), Jacqueline C M Witteman (Collaborator), Caroline Hayward (Collaborator), Paul Ridker (Collaborator), Afshin Parsa (Collaborator), Murielle Bochud (Collaborator), Iris M Heid (Collaborator), Wolfram Goessling (Collaborator), Caroline S Fox (Collaborator), Ian H de Boer (Collaborator), Nicole L Glazer (Collaborator), Carmen A Peralta (Collaborator), Zoltán Kutalik (Collaborator), Jian'an Luan (Collaborator), Jing Hua Zhao (Collaborator), Ermeg Akylbekova (Collaborator), Holly Kramer (Collaborator), Pim van der Harst (Collaborator), Dan E Arking (Collaborator), Nora Franceschini (Collaborator), Josephine Egan (Collaborator), Dena Hernandez (Collaborator), Muredach Reilly (Collaborator), Raymond R Townsend (Collaborator), Thomas Lumley (Collaborator), Bryan Kestenbaum (Collaborator), Talin Haritunians (Collaborator), Gerard Waeber (Collaborator), Vincent Mooser (Collaborator), Dawn Waterworth (Collaborator), Jose C Florez (Collaborator), James B Meigs (Collaborator), Xiaoning Lu (Collaborator), Tennille S Leak (Collaborator), Knut Aasarød (Collaborator), Frank Skorpen (Collaborator), Jens Baumert (Collaborator), Olivier Devuyst (Collaborator), Josyf C Mychaleckyj (Collaborator), Stephan J L Bakker (Collaborator), Lyudmyla Kedenko (Collaborator), Stefan Coassin (Collaborator), Nicholas D Hastie (Collaborator), Gary Curhan (Collaborator), Johan Ärnlöv (Collaborator), Stein Hallan (Collaborator), Gerjan Navis (Collaborator), Michael G Shlipak (Collaborator), Shelley B Bull (Collaborator), Andrew D Paterson (Collaborator), Ruth J F Loos (Collaborator), Jerome I Rotter (Collaborator), L Adrienne Cupples (Collaborator), Jacques S Beckmann (Collaborator), Albert W Dreisbach (Collaborator), W H L Kao (Collaborator), Carl A Anderson (Collaborator), Scott D Gordon (Collaborator), Qun Guo (Collaborator), Anjali K Henders (Collaborator), Ann Lambert (Collaborator), Sang Hong Lee (Collaborator), Peter Kraft (Collaborator), Stephen H Kennedy (Collaborator), Stuart Macgregor (Collaborator), Nicholas G Martin (Collaborator), Stacey A Missmer (Collaborator), Grant W Montgomery (Collaborator), Andrew P Morris (Collaborator), Dale R Nyholt (Collaborator), Jodie N Painter (Collaborator), Fenella Roseman (Collaborator), Susan A Treloar (Collaborator), Peter M Visscher (Collaborator), Leanne Wallace (Collaborator), Krina T Zondervan (Collaborator), Niina Sandholm (Collaborator), Rany M Salem (Collaborator), Amy Jayne McKnight (Collaborator), Eoin P Brennan (Collaborator), Carol Forsblom (Collaborator), Tamara Isakova (Collaborator), Gareth J McKay (Collaborator), Winfred W Williams (Collaborator), Denise M Sadlier (Collaborator), Ville-Petteri Mäkinen (Collaborator), Elizabeth J Swan (Collaborator), Cameron Palmer (Collaborator), Andrew P Boright (Collaborator), Emma Ahlqvist (Collaborator), Harshal A Deshmukh (Collaborator), Benjamin J Keller (Collaborator), Huateng Huang (Collaborator), Aila Ahola (Collaborator), Emma Fagerholm (Collaborator), Daniel Gordin (Collaborator), Valma Harjutsalo (Collaborator), Bing He (Collaborator), Outi Heikkilä (Collaborator), Kustaa Hietala (Collaborator), Janne Kytö (Collaborator), Päivi Lahermo (Collaborator), Markku Lehto (Collaborator), Anne-May Österholm (Collaborator), Maija Parkkonen (Collaborator), Janne Pitkäniemi (Collaborator), Milla Rosengård-Bärlund (Collaborator), Markku Saraheimo (Collaborator), Cinzia Sarti (Collaborator), Jenny Söderlund (Collaborator), Aino Soro-Paavonen (Collaborator), Anna Syreeni (Collaborator), Lena M Thorn (Collaborator), Heikki Tikkanen (Collaborator), Nina Tolonen (Collaborator), Karl Tryggvason (Collaborator), Jaakko Tuomilehto (Collaborator), Johan Wadén (Collaborator), Geoffrey V Gill (Collaborator), Sarah Prior (Collaborator), Candace Guiducci (Collaborator), Andrew Taylor (Collaborator), Mohsen Hosseini (Collaborator), Hans-Henrik Parving (Collaborator), Peter Rossing (Collaborator), Lise Tarnow (Collaborator), Claes Ladenvall (Collaborator), François Alhenc-Gelas (Collaborator), Pierre Lefebvre (Collaborator), Vincent Rigalleau (Collaborator), Ronan Roussel (Collaborator), David-Alexandre Tregouet (Collaborator), Anna Maestroni (Collaborator), Silvia Maestroni (Collaborator), Henrik Falhammar (Collaborator), Tianwei Gu (Collaborator), Anna Möllsten (Collaborator), Dan Cimponeriu (Collaborator), Ioana Mihai (Collaborator), Maria Mota (Collaborator), Eugen Mota (Collaborator), Cristian Serafinceanu (Collaborator), Monica Stavarachi (Collaborator), Robert L Hanson (Collaborator), Robert G Nelson (Collaborator), Matthias Kretzler (Collaborator), Helen M Colhoun (Collaborator), Nicolae Mircea Panduru (Collaborator), Harvest F Gu (Collaborator), Kerstin Brismar (Collaborator), Gianpaolo Zerbini (Collaborator), Samy Hadjadj (Collaborator), Michel Marre (Collaborator), Maria Lajer (Collaborator), Daryl Waggott (Collaborator), David A Savage (Collaborator), Stephen C Bain (Collaborator), Finian Martin (Collaborator), Joel N Hirschhorn (Collaborator), Catherine Godson (Collaborator), Per-Henrik Groop (Collaborator), Alexander P Maxwell (Collaborator), Ellen M Schmidt (Collaborator), Sebanti Sengupta (Collaborator), Gina M Peloso (Collaborator), Andrea Ganna (Collaborator), Jin Chen (Collaborator), Martin L Buchkovich (Collaborator), Samia Mora (Collaborator), Jennifer L Bragg-Gresham (Collaborator), Hsing-Y Chang (Collaborator), Ayşe Demirkan (Collaborator), Heleen M Den Hertog (Collaborator), Louise A Donnelly (Collaborator), Teresa Ferreira (Collaborator), Ross M Fraser (Collaborator), Daniel F Freitag (Collaborator), Deepti Gurdasani (Collaborator), Kauko Heikkilä (Collaborator), Elina Hyppönen (Collaborator), Anne U Jackson (Collaborator), Toby Johnson (Collaborator), Marika Kaakinen (Collaborator), Johannes Kettunen (Collaborator), Xiaohui Li (Collaborator), Patrik K E Magnusson (Collaborator), Massimo Mangino (Collaborator), May E 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(Collaborator), John J P Kastelein (Collaborator), Kay-Tee Khaw (Collaborator), Eric Kim (Collaborator), Pirjo Komulainen (Collaborator), Meena Kumari (Collaborator), Terho Lehtimaki (Collaborator), Shih-Yi Lin (Collaborator), Jaana Lindstrom (Collaborator), François Mach (Collaborator), Wendy L McArdle (Collaborator), Gabrielle Muller (Collaborator), Ramaiah Nagaraja (Collaborator), Narisu Narisu (Collaborator), Tuomo V M Nieminen (Collaborator), Rebecca N Nsubuga (Collaborator), Isleifur Olafsson (Collaborator), Ken K Ong (Collaborator), Aarno Palotie (Collaborator), Theodore Papamarkou (Collaborator), Cristina Pomilla (Collaborator), Anneli Pouta (Collaborator), Aimo Ruokonen (Collaborator), Nilesh Samani (Collaborator), Hubert Scharnagl (Collaborator), Janet Seeley (Collaborator), Kaisa Silander (Collaborator), Alena Stančáková (Collaborator), Amy J Swift (Collaborator), Laurence Tiret (Collaborator), L Joost van Pelt (Collaborator), Sailaja Vedantam (Collaborator), Nicholas Wainwright (Collaborator), Cisca Wijmenga (Collaborator), Gonneke Willemsen (Collaborator), Tom Wilsgaard (Collaborator), Elizabeth H Young (Collaborator), Linda S Adair (Collaborator), Stefania Bandinelli (Collaborator), Franklyn Bennett (Collaborator), Dorret I Boomsma (Collaborator), Stefan R Bornstein (Collaborator), Pascal Bovet (Collaborator), Michel Burnier (Collaborator), Aravinda Chakravarti (Collaborator), Yii-Der Ida Chen (Collaborator), Francis S Collins (Collaborator), Richard S Cooper (Collaborator), Alan B Feranil (Collaborator), Jean Ferrieres (Collaborator), Nelson B Freimer (Collaborator), Christian Gieger (Collaborator), Aroon Hingorani (Collaborator), Chao Agnes Hsiung (Collaborator), Steve E Humphries (Collaborator), Steven C Hunt (Collaborator), Kristian Hveem (Collaborator), Marjo-Riitta Jarvelin (Collaborator), Antti Jula (Collaborator), Jaakko Kaprio (Collaborator), Antero Kesäniemi (Collaborator), Mika Kivimaki (Collaborator), Peter J Koudstaal (Collaborator), Ronald M Krauss (Collaborator), Diana Kuh (Collaborator), Kirsten O Kyvik (Collaborator), Timo A Lakka (Collaborator), Cecilia M Lindgren (Collaborator), Colin A McKenzie (Collaborator), Pierre Meneton (Collaborator), Leena Moilanen (Collaborator), Inger Njølstad (Collaborator), Chris Power (Collaborator), Jackie F Price (Collaborator), Rainer Rauramaa (Collaborator), Dharambir K Sanghera (Collaborator), Jouko Saramies (Collaborator), Peter E H Schwarz (Collaborator), Wayne H-H Sheu (Collaborator), Tim D Spector (Collaborator), David P Strachan (Collaborator), Elena Tremoli (Collaborator), Matti Uusitupa (Collaborator), John B Whitfield (Collaborator), Bruce H R Wolffenbuttel (Collaborator), Jose M Ordovas (Collaborator), Stephen S Rich (Collaborator), Karen L Mohlke (Collaborator), Gonçalo Abecasis (Collaborator), Mark Caulfield (Collaborator), Dan Chasman (Collaborator), Georg Ehret (Collaborator), Andrew Johnson (Collaborator), Louise Johnson (Collaborator), Martin Larson (Collaborator), Daniel Levy (Collaborator), Patricia Munroe (Collaborator), Christopher Newton-Cheh (Collaborator), Paul O'Reilly (Collaborator), Walter Palmas (Collaborator), Bruce Psaty (Collaborator), Kenneth Rice (Collaborator), Albert Smith (Collaborator), Harold Snider (Collaborator), Martin Tobin (Collaborator), Cornelia Van Duijn (Collaborator), Germaine Verwoert (Collaborator), Kenneth M Rice (Collaborator), Martin D Tobin (Collaborator), Germaine C Verwoert (Collaborator), Vasyl Pihur (Collaborator), Paul F O'Reilly (Collaborator), Najaf Amin (Collaborator), Lenore Launer (Collaborator), Yurii Aulchenko (Collaborator), Simon Heath (Collaborator), Siim Sõber (Collaborator), Pankaj Arora (Collaborator), Feng Zhang (Collaborator), Gavin Lucas (Collaborator), Yuri Milaneschi (Collaborator), Alex N Parker (Collaborator), Cristiano Fava (Collaborator), Ervin R Fox (Collaborator), Min Jin Go (Collaborator), Wen Hong Linda Kao (Collaborator), Marketa Sjögren (Collaborator), D G Vinay (Collaborator), Myriam Alexander (Collaborator), Yasuharu Tabara (Collaborator), Sue Shaw-Hawkins (Collaborator), Peter H Whincup (Collaborator), Gang Shi (Collaborator), Bamidele Tayo (Collaborator), Mark Seielstad (Collaborator), Xueling Sim (Collaborator), Khanh-Dung Hoang Nguyen (Collaborator), Giuseppe Matullo (Collaborator), Tom R Gaunt (Collaborator), N Charlotte Onland-Moret (Collaborator), Matthew N Cooper (Collaborator), Carl G P Platou (Collaborator), Elin Org (Collaborator), Rebecca Hardy (Collaborator), Santosh Dahgam (Collaborator), Jutta Palmen (Collaborator), Tatiana Kuznetsova (Collaborator), Cuno S P M Uiterwaal (Collaborator), Adebowale Adeyemo (Collaborator), Barbara Ludwig (Collaborator), Maciej Tomaszewski (Collaborator), Ioanna Tzoulaki (Collaborator), Nicholette D Palmer (Collaborator), Melissa Garcia (Collaborator), Yen-Pei C Chang (Collaborator), Nanette I Steinle (Collaborator), Diederick E Grobbee (Collaborator), Sharon L Kardia (Collaborator), Alanna C 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(Collaborator), Ayellet V Segrè (Collaborator), Ulla Sovio (Collaborator), Sathanur R Srinivasan (Collaborator), Mar-Liis Tammesoo (Collaborator), Jonathon Tyrer (Collaborator), Joyve B J van Meurs (Collaborator), Michael N Weedon (Collaborator), Lauren Young (Collaborator), Wei Vivian Zhuang (Collaborator), Laura J Bierut (Collaborator), Heather A Boyd (Collaborator), Michael J Econs (Collaborator)

Research output: Contribution to journalArticlepeer-review

Abstract

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P <5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
Original languageEnglish
JournalNature
Volume518
Issue number7538
DOIs
Publication statusPublished - 12 Feb 2015

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