Genetic susceptibility to hip arthroplasty failure - Association with the RANK/OPG pathway

Hammad Malik; M. H A Malik; A. Bayat; F. Jury; W. E R Ollier; P. R. Kay

doi:10.1007/s00264-006-0074-2

Genetic susceptibility to hip arthroplasty failure - Association with the RANK/OPG pathway

Hammad Malik, M. H A Malik, A. Bayat, F. Jury, W. E R Ollier, P. R. Kay

Research output: Contribution to journal › Article › peer-review

Abstract

The OPG/RANK/RANKL system has been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection resulting in periprosthetic bone loss around total hip arthroplasties (THA). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). Case control study of the osteoprotegerin and RANK genes for possible association with deep sepsis or aseptic loosening. All patients were Caucasian and had had a cemented Charnley THA and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with deep infection. Controls were 150 clinically and radiologically well-fixed THAs. DNA samples were genotyped using Taqman allelic discrimination. The A allele (p

Original language	English
Pages (from-to)	177-181
Number of pages	4
Journal	International Orthopaedics
Volume	30
Issue number	3
DOIs	https://doi.org/10.1007/s00264-006-0074-2
Publication status	Published - Jun 2006

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abstract = "The OPG/RANK/RANKL system has been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection resulting in periprosthetic bone loss around total hip arthroplasties (THA). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). Case control study of the osteoprotegerin and RANK genes for possible association with deep sepsis or aseptic loosening. All patients were Caucasian and had had a cemented Charnley THA and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with deep infection. Controls were 150 clinically and radiologically well-fixed THAs. DNA samples were genotyped using Taqman allelic discrimination. The A allele (p",

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AU - Malik, Hammad

AU - Malik, M. H A

AU - Bayat, A.

AU - Jury, F.

AU - Ollier, W. E R

AU - Kay, P. R.

PY - 2006/6

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AB - The OPG/RANK/RANKL system has been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection resulting in periprosthetic bone loss around total hip arthroplasties (THA). Individual responses to such stimuli may be dictated by genetic variation caused by single nucleotide polymorphisms (SNPs). Case control study of the osteoprotegerin and RANK genes for possible association with deep sepsis or aseptic loosening. All patients were Caucasian and had had a cemented Charnley THA and polyethylene acetabular cup. Cases consisted of 91 patients with early aseptic loosening and 71 patients with deep infection. Controls were 150 clinically and radiologically well-fixed THAs. DNA samples were genotyped using Taqman allelic discrimination. The A allele (p

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JO - International Orthopaedics

JF - International Orthopaedics

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Genetic susceptibility to hip arthroplasty failure - Association with the RANK/OPG pathway

Abstract

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