Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Mira M. Wouters; Diether Lambrechts; Michael Knapp; Isabelle Cleynen; Peter Whorwell; Lars Agréus; Aldona Dlugosz; Peter Thelin Schmidt; Jonas Halfvarson; Magnus Simrén; Bodil Ohlsson; Pontus Karling; Sander Van Wanrooy; Stéphanie Mondelaers; Severine Vermeire; Greger Lindberg; Robin Spiller; George Dukes; Mauro D'Amato; Guy Boeckxstaens

doi:10.1136/gutjnl-2013-304570

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Mira M. Wouters, Diether Lambrechts, Michael Knapp, Isabelle Cleynen, Peter Whorwell, Lars Agréus, Aldona Dlugosz, Peter Thelin Schmidt, Jonas Halfvarson, Magnus Simrén, Bodil Ohlsson, Pontus Karling, Sander Van Wanrooy, Stéphanie Mondelaers, Severine Vermeire, Greger Lindberg, Robin Spiller, George Dukes, Mauro D'Amato, Guy Boeckxstaens

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design: 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (935 IBS patients, 639 controls). 33 SNPs with P uncorrected

Original language	English
Pages (from-to)	1103-1111
Number of pages	8
Journal	Gut
Volume	63
Issue number	7
DOIs	https://doi.org/10.1136/gutjnl-2013-304570
Publication status	Published - 2014

Keywords

GENETIC POLYMORPHISMS
IMMUNE RESPONSE

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http://gut.bmj.com/content/63/7/1103.full.pdf

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Wouters, M. M., Lambrechts, D., Knapp, M., Cleynen, I., Whorwell, P., Agréus, L., Dlugosz, A., Schmidt, P. T., Halfvarson, J., Simrén, M., Ohlsson, B., Karling, P., Van Wanrooy, S., Mondelaers, S., Vermeire, S., Lindberg, G., Spiller, R., Dukes, G., D'Amato, M., & Boeckxstaens, G. (2014). Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome. Gut, 63(7), 1103-1111. https://doi.org/10.1136/gutjnl-2013-304570

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title = "Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome",

abstract = "Objective: The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design: 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (935 IBS patients, 639 controls). 33 SNPs with P uncorrected",

keywords = "GENETIC POLYMORPHISMS, IMMUNE RESPONSE",

author = "Wouters, {Mira M.} and Diether Lambrechts and Michael Knapp and Isabelle Cleynen and Peter Whorwell and Lars Agr{\'e}us and Aldona Dlugosz and Schmidt, {Peter Thelin} and Jonas Halfvarson and Magnus Simr{\'e}n and Bodil Ohlsson and Pontus Karling and {Van Wanrooy}, Sander and St{\'e}phanie Mondelaers and Severine Vermeire and Greger Lindberg and Robin Spiller and George Dukes and Mauro D'Amato and Guy Boeckxstaens",

year = "2014",

doi = "10.1136/gutjnl-2013-304570",

language = "English",

volume = "63",

pages = "1103--1111",

journal = "Gut",

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publisher = "BMJ ",

number = "7",

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Wouters, MM, Lambrechts, D, Knapp, M, Cleynen, I, Whorwell, P, Agréus, L, Dlugosz, A, Schmidt, PT, Halfvarson, J, Simrén, M, Ohlsson, B, Karling, P, Van Wanrooy, S, Mondelaers, S, Vermeire, S, Lindberg, G, Spiller, R, Dukes, G, D'Amato, M & Boeckxstaens, G 2014, 'Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome', Gut, vol. 63, no. 7, pp. 1103-1111. https://doi.org/10.1136/gutjnl-2013-304570

TY - JOUR

T1 - Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

AU - Wouters, Mira M.

AU - Lambrechts, Diether

AU - Knapp, Michael

AU - Cleynen, Isabelle

AU - Whorwell, Peter

AU - Agréus, Lars

AU - Dlugosz, Aldona

AU - Schmidt, Peter Thelin

AU - Halfvarson, Jonas

AU - Simrén, Magnus

AU - Ohlsson, Bodil

AU - Karling, Pontus

AU - Van Wanrooy, Sander

AU - Mondelaers, Stéphanie

AU - Vermeire, Severine

AU - Lindberg, Greger

AU - Spiller, Robin

AU - Dukes, George

AU - D'Amato, Mauro

AU - Boeckxstaens, Guy

PY - 2014

Y1 - 2014

N2 - Objective: The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design: 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (935 IBS patients, 639 controls). 33 SNPs with P uncorrected

AB - Objective: The complex genetic aetiology underlying irritable bowel syndrome (IBS) needs to be assessed in large-scale genetic studies. Two independent IBS cohorts were genotyped to assess whether genetic variability in immune, neuronal and barrier integrity genes is associated with IBS. Design: 384 single nucleotide polymorphisms (SNPs) covering 270 genes were genotyped in an exploratory cohort (935 IBS patients, 639 controls). 33 SNPs with P uncorrected

KW - GENETIC POLYMORPHISMS

KW - IMMUNE RESPONSE

U2 - 10.1136/gutjnl-2013-304570

DO - 10.1136/gutjnl-2013-304570

M3 - Article

C2 - 24041540

SN - 0017-5749

VL - 63

SP - 1103

EP - 1111

JO - Gut

JF - Gut

IS - 7

ER -

Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome

Abstract

Keywords

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