Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

N Johnson, F Dudbridge, N Orr, L Gibson, M E Jones, M J Schoemaker, E J Folkerd, B P Haynes, J L Hopper, M C Southey, G S Dite, C Apicella, M K Schmidt, A Broeks, T Veer L J Van, F Atsma, K Muir, A Lophatananon, P A Fasching, M W BeckmannA B Ekici, S P Renner, E Sawyer, I Tomlinson, M Kerin, N Miller, B Burwinkel, F Marme, A Schneeweiss, C Sohn, P Guenel, T Truong, E Cordina, F Menegaux, S E Bojesen, B G Nordestgaard, H Flyger, R Milne, M P Zamora, J I Arias Perez, J Benitez, L Bernstein, H Anton-Culver, A Ziogas, C Clarke Dur, H Brenner, H Muller, V Arndt, A K Dieffenbach, A Meindl, J Heil, C R Bartram, R K Schmutzler, H Brauch, C Justenhoven, Y D Ko, H Nevanlinna, T A Muranen, K Aittomaki, C Blomqvist, K Matsuo, T Dork, N V Bogdanova, N N Antonenkova, A Lindblom, A Mannermaa, V Kataja, V M Kosma, J M Hartikainen, G Chenevix-Trench, J Beesley, A H Wu, D Van den Berg, C C Tseng, D Lambrechts, D Smeets, P Neven, H Wildiers, J Chang-Claude, A Rudolph, S Nickels, D Flesch-Janys, P Radice, P Peterlongo, B Bonanni, V Pensotti, F J Couch, J E Olson, X Wang, Z Fredericksen, V S Pankratz, G G Giles, G Severi, L Baglietto, C Haiman, J Simard, M S Goldberg, F Labreche, M Dumont, P Soucy, S Teo, C H Yip, S Y Phuah, B K Cornes, V N Kristensen, G Grenaker Alnaes, A L Borresen-Dale, W Zheng, R Winqvist, K Pylkas, A Jukkola-Vuorinen, M Grip, I L Andrulis, J A Knight, G Glendon, A M Mulligan, P Devillee, J Figueroa, S J Chanock, J Lissowska, M E Sherman, P Hall, N Schoof, M Hooning, A Hollestelle, R A Oldenburg, M Tilanus-Linthorst, J Liu, A Cox, I W Brock, M W Reed, S S Cross, W Blot, L B Signorello, P D Pharoah, A M Dunning, M Shah, D Kang, D Y Noh, S K Park, J Y Choi, M Hartman, H Miao, W Y Lim, A Tang, U Hamann, A Forsti, T Rudiger, H U Ulmer, A Jakubowska, J Lubinski, K Jaworska-Bieniek, K Durda, S Sangrajrang, V Gaborieau, P Brennan, J McKay, S Slager, A E Toland, C Vachon, D Yannoukakos, C Y Shen, J C Yu, C S Huang, M F Hou, A Gonzalez-Neira, D C Tessier, D Vincent, F Bacot, C Luccarini, J Dennis, K Michailidou, M K Bolla, J Wang, D F Easton, M Garcia-Closas, M Dowsett, A Ashworth, A J Swerdlow, J Peto, I Dos Santos Silva, O Fletcher

    Research output: Contribution to journalArticlepeer-review

    Abstract

    INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age =15 years (ORhet = 0.84, 95% CI 0.75, 0.94; ORhom = 0.81, 95% CI 0.51, 1.30; Ptrend = 0.002) but not for those who had their menarche age
    Original languageEnglish
    JournalBreast Cancer Res
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - 2014

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