Abstract
Background and aims
Haplogroup I – a common European paternal lineage of the Y chromosome is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroups on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance.
Methods
We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n=1,217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n=393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men.
Results
A majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men.
Conclusions
Our data show that genetic variation on the Y chromosome is not associated with histological characteristics of the the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin.
Haplogroup I – a common European paternal lineage of the Y chromosome is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroups on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance.
Methods
We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n=1,217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n=393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men.
Results
A majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men.
Conclusions
Our data show that genetic variation on the Y chromosome is not associated with histological characteristics of the the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin.
| Original language | English |
|---|---|
| Pages (from-to) | 114-119 |
| Number of pages | 6 |
| Journal | Atherosclerosis |
| Volume | 259 |
| Early online date | 20 Feb 2017 |
| DOIs | |
| Publication status | Published - Apr 2017 |
