Genetics and genomics of radiotherapy toxicity: Towards prediction

Catharine M. West; Gillian C. Barnett

doi:10.1186/gm268

Genetics and genomics of radiotherapy toxicity: Towards prediction

Research output: Contribution to journal › Article › peer-review

Abstract

Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority limits the radiation doses that can be safely prescribed to the majority. Radiogenomics is the whole genome application of radiogenetics, which studies the influence of genetic variation on radiation response. Work in the area focuses on uncovering the underlying genetic causes of individual variation in sensitivity to radiation, which is important for effective, safe treatment. In this review, we highlight recent advances in radiotherapy and discuss results from four genome-wide studies of radiotoxicity. © 2011 BioMed Central Ltd.

Original language	English
Article number	52
Journal	Genome Medicine
Volume	3
Issue number	8
DOIs	https://doi.org/10.1186/gm268
Publication status	Published - 23 Aug 2011

Keywords

Genome-wide association study
Radiation
Radiothe
Rapyradiogenomics
Single nucleotide polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/gm268

http://genomemedicine.com/content/3/8/52

Cite this

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abstract = "Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority limits the radiation doses that can be safely prescribed to the majority. Radiogenomics is the whole genome application of radiogenetics, which studies the influence of genetic variation on radiation response. Work in the area focuses on uncovering the underlying genetic causes of individual variation in sensitivity to radiation, which is important for effective, safe treatment. In this review, we highlight recent advances in radiotherapy and discuss results from four genome-wide studies of radiotoxicity. {\textcopyright} 2011 BioMed Central Ltd.",

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AU - Barnett, Gillian C.

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N2 - Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority limits the radiation doses that can be safely prescribed to the majority. Radiogenomics is the whole genome application of radiogenetics, which studies the influence of genetic variation on radiation response. Work in the area focuses on uncovering the underlying genetic causes of individual variation in sensitivity to radiation, which is important for effective, safe treatment. In this review, we highlight recent advances in radiotherapy and discuss results from four genome-wide studies of radiotoxicity. © 2011 BioMed Central Ltd.

AB - Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with the consequences of treatment, and toxicity in a minority limits the radiation doses that can be safely prescribed to the majority. Radiogenomics is the whole genome application of radiogenetics, which studies the influence of genetic variation on radiation response. Work in the area focuses on uncovering the underlying genetic causes of individual variation in sensitivity to radiation, which is important for effective, safe treatment. In this review, we highlight recent advances in radiotherapy and discuss results from four genome-wide studies of radiotoxicity. © 2011 BioMed Central Ltd.

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KW - Radiation

KW - Radiothe

KW - Rapyradiogenomics

KW - Single nucleotide polymorphism

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Genetics and genomics of radiotherapy toxicity: Towards prediction

Abstract

Keywords

UN SDGs

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