Genetics of human essential hypertension: from single mutations to quantitative trait loci

Maciej Tomaszewski, Nick JR Brain, Fadi J Charchar, Anna F Dominiczak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Essential hypertension is a typical example of a complex, heterogeneous, polygenic trait.1 Multiple genes and at least several environmental factors (such as alcohol consumption or lack of physical activity) interact together contributing to high blood pressure. The contribution of genetic factors to blood pressure variation is estimated to be about 30%. However, the number of loci responsible for essential hypertension, precise mechanisms of gene-gene and gene-environment interactions, as well as the functional significance of these effects at a protein level are not known. Although the pathogenesis of high blood pressure has not been elucidated fully yet, the achievements of cardiovascular genetics should not be underestimated.
Original languageEnglish
Title of host publicationMolecular Mechanisms in Hypertension
EditorsRichard N. Re
PublisherCRC Press
Chapter27
Pages241-8
Number of pages8
ISBN (Print)9781842143049
Publication statusPublished - 2006

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