Genetics of rheumatoid arthritis susceptibility, severity and treatment response

Sebastien Viatte; Anne Barton

doi:10.1007/s00281-017-0630-4

Genetics of rheumatoid arthritis susceptibility, severity and treatment response

Sebastien Viatte, Anne Barton

Division of Musculoskeletal & Dermatological Sciences (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

A decade after the first genome-wide association study in rheumatoid arthritis (RA), a plethora of genetic association studies have been published on RA and its clinical or serological subtypes. We review the major milestones in the study of the genetic architecture of RA susceptibility, severity and response to treatment. We set the scientific context necessary for non-geneticists to understand the potential clinical applications of human genetics and its significance for a stratified approach to the management of RA in the future.

Original language	English
Journal	Seminars in Immunopathology
Early online date	29 May 2017
DOIs	https://doi.org/10.1007/s00281-017-0630-4
Publication status	Published - 30 Jun 2017

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10.1007/s00281-017-0630-4Licence: CC BY

Arthritis Research UK Centre of Excellence in the Genetics of Rheumatic Diseases.
Worthington, J. (PI), Barton, A. (CoI), Black, G. (CoI), Crow, Y. (CoI), Eyre, S. (CoI), Raychaudhuri, S. (CoI) & Thomson, W. (CoI)
1/08/13 → 31/07/18
Project: Research

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title = "Genetics of rheumatoid arthritis susceptibility, severity and treatment response",

abstract = "A decade after the first genome-wide association study in rheumatoid arthritis (RA), a plethora of genetic association studies have been published on RA and its clinical or serological subtypes. We review the major milestones in the study of the genetic architecture of RA susceptibility, severity and response to treatment. We set the scientific context necessary for non-geneticists to understand the potential clinical applications of human genetics and its significance for a stratified approach to the management of RA in the future.",

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Genetics of rheumatoid arthritis susceptibility, severity and treatment response

Abstract

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Arthritis Research UK Centre of Excellence in the Genetics of Rheumatic Diseases.

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