Genome and proteome annotation: Organization, interpretation and integration

Gabrielle A. Reeves, David Talavera, Janet M. Thornton

    Research output: Contribution to journalArticlepeer-review


    Recent years have seen a huge increase in the generation of genomic and proteomic data. This has been due to improvements in current biological methodologies, the development of new experimental techniques and the use of computers as support tools. All these raw data are useless if they cannot be properly analysed, annotated, stored and displayed. Consequently, a vast number of resources have been created to present the data to the wider community. Annotation tools and databases provide the means to disseminate these data and to comprehend their biological importance. This review examines the various aspects of annotation: type, methodology and availability. Moreover, it puts a special interest on novel annotation fields, such as that of phenotypes, and highlights the recent efforts focused on the integrating annotations. © 2008 The Royal Society.
    Original languageEnglish
    Pages (from-to)129-147
    Number of pages18
    JournalJournal of the Royal Society Interface
    Issue number1
    Publication statusPublished - 6 Feb 2009


    • Genome annotation
    • Proteome annotation
    • Sequencing


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