@article{e7cfb9de0f1f4f8eb3415b51d95ba1c1,
title = "Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits",
abstract = "Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (~26%-27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n = 880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ~2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels (p",
author = "Soumya Raychaudhuri and Speliotes, {Elizabeth K.} and Yerges-Armstrong, {Laura M.} and Jun Wu and Ruben Hernaez and Kim, {Lauren J.} and Palmer, {Cameron D.} and Vilmundur Gudnason and Gudny Eiriksdottir and Garcia, {Melissa E.} and Launer, {Lenore J.} and Nalls, {Michael A.} and Clark, {Jeanne M.} and Mitchell, {Braxton D.} and Shuldiner, {Alan R.} and Butler, {Johannah L.} and Marta Tomas and Udo Hoffmann and Hwang, {Shih Jen} and Massaro, {Joseph M.} and O'Donnell, {Christopher J.} and Sahani, {Dushyant V.} and Veikko Salomaa and Schadt, {Eric E.} and Schwartz, {Stephen M.} and Siscovick, {David S.} and Voight, {Benjamin F.} and Carr, {J. Jeffrey} and Feitosa, {Mary F.} and Harris, {Tamara B.} and Fox, {Caroline S.} and Smith, {Albert V.} and Kao, {W. H Linda} and Hirschhorn, {Joel N.} and Borecki, {Ingrid B.}",
note = "F32 DK079466-01, NIDDK NIH HHS, United StatesF32AR059469, NIAMS NIH HHS, United StatesK01 DK067207, NIDDK NIH HHS, United StatesK23DK080145-01, NIDDK NIH HHS, United StatesK24 DK002957-09, NIDDK NIH HHS, United StatesM01RR000065, NCRR NIH HHS, United StatesM01RR000750, NCRR NIH HHS, United StatesM01RR000827, NCRR NIH HHS, United StatesM01RR00188, NCRR NIH HHS, United StatesM01RR020359, NCRR NIH HHS, United StatesN01-AG-12100, NIA NIH HHS, United StatesN01-HC-25195, NHLBI NIH HHS, United StatesN02-HL-6-4278, NHLBI NIH HHS, United StatesP30DK072488, NIDDK NIH HHS, United StatesP60 DK079637, NIDDK NIH HHS, United StatesR01 AG18728, NIA NIH HHS, United StatesR01DK075681, NIDDK NIH HHS, United StatesR01DK075787, NIDDK NIH HHS, United StatesR01HL087700, NHLBI NIH HHS, United StatesR01HL088119, NHLBI NIH HHS, United StatesT32 DK07191-32, NIDDK NIH HHS, United StatesT32AG000262, NIA NIH HHS, United StatesU01 DK061728-09, NIDDK NIH HHS, United StatesU01 HL084756, NHLBI NIH HHS, United StatesU01 HL72515, NHLBI NIH HHS, United StatesU01DK061713, NIDDK NIH HHS, United StatesU01DK061718, NIDDK NIH HHS, United StatesU01DK061728, NIDDK NIH HHS, United StatesU01DK061730, NIDDK NIH HHS, United StatesU01DK061731, NIDDK NIH HHS, United StatesU01DK061732, NIDDK NIH HHS, United StatesU01DK061734, NIDDK NIH HHS, United StatesU01DK061737, NIDDK NIH HHS, United StatesU01DK061738, NIDDK NIH HHS, United StatesUL1RR024989, NCRR NIH HHS, United StatesUL1RR02501401, NCRR NIH HHS, United StatesULRR02413101, PHS HHS, United States",
year = "2011",
month = mar,
doi = "10.1371/journal.pgen.1001324",
language = "English",
volume = "7",
journal = "PL o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "3",
}