@article{10948d2a694d45a4abc6179302de6ab2,
title = "Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake",
abstract = "Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P ",
keywords = "Gene expression, Genome-wide association studies, Metabolic disorders, Population genetics, Type 2 diabetes",
author = "{The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC)} and Alice Williamson and Norris, {Dougall M.} and Xianyong Yin and Broadaway, {K. Alaine} and Moxley, {Anne H.} and Swarooparani Vadlamudi and Wilson, {Emma P.} and Jackson, {Anne U.} and Vasudha Ahuja and Andersen, {Mette K.} and Zorayr Arzumanyan and Bonnycastle, {Lori L.} and Bornstein, {Stefan R.} and Bretschneider, {Maxi P.} and Buchanan, {Thomas A.} and Yi-cheng Chang and Lee-ming Chuang and Ren-hua Chung and Clausen, {Tine D.} and Peter Damm and Delgado, {Graciela E.} and {De mello}, {Vanessa D.} and Jos{\'e}e Dupuis and Dwivedi, {Om P.} and Erdos, {Michael R.} and Silva, {Lilian Fernandes} and Frayling, {Timothy M.} and Christian Gieger and Goodarzi, {Mark O.} and Xiuqing Guo and Stefan Gustafsson and Liisa Hakaste and Ulf Hammar and Gad Hatem and Sandra Herrmann and Kurt H{\o}jlund and Katrin Horn and Hsueh, {Willa A.} and Yi-jen Hung and Chii-min Hwu and Anna Jonsson and K{\aa}rhus, {Line L.} and Kleber, {Marcus E.} and Peter Kovacs and Lakka, {Timo A.} and Marie Lauzon and I-te Lee and Lindgren, {Cecilia M.} and Ching-ti Liu and Morris, {Andrew P.}",
year = "2023",
month = jun,
day = "8",
doi = "10.1038/s41588-023-01408-9",
language = "English",
volume = "55",
pages = "973--983",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Research",
number = "6",
}
