Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1131-1138 |
| Number of pages | 7 |
| Journal | Nature Genetics |
| Volume | 43 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2011 |
Access to Document
Fingerprint
Dive into the research topics of 'Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Nature Genetics, Vol. 43, No. 11, 11.2011, p. 1131-1138.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
AU - Raychaudhuri, Soumya
AU - Chambers, John C.
AU - Zhang, Weihua
AU - Sehmi, Joban
AU - Li, Xinzhong
AU - Wass, Mark N.
AU - Van Der Harst, Pim
AU - Holm, Hilma
AU - Sanna, Serena
AU - Kavousi, Maryam
AU - Baumeister, Sebastian E.
AU - Coin, Lachlan J.
AU - Deng, Guohong
AU - Gieger, Christian
AU - Heard-Costa, Nancy L.
AU - Hottenga, Jouke Jan
AU - Kühnel, Brigitte
AU - Kumar, Vinod
AU - Lagou, Vasiliki
AU - Liang, Liming
AU - Luan, Jian'An
AU - Vidal, Pedro Marques
AU - Leach, Irene Mateo
AU - O'Reilly, Paul F.
AU - Peden, John F.
AU - Rahmioglu, Nilufer
AU - Soininen, Pasi
AU - Speliotes, Elizabeth K.
AU - Yuan, Xin
AU - Thorleifsson, Gudmar
AU - Alizadeh, Behrooz Z.
AU - Atwood, Larry D.
AU - Borecki, Ingrid B.
AU - Brown, Morris J.
AU - Charoen, Pimphen
AU - Cucca, Francesco
AU - Das, Debashish
AU - De Geus, Eco J C
AU - Dixon, Anna L.
AU - Döring, Angela
AU - Ehret, Georg
AU - Eyjolfsson, Gudmundur I.
AU - Farrall, Martin
AU - Forouhi, Nita G.
AU - Friedrich, Nele
AU - Goessling, Wolfram
AU - Gudbjartsson, Daniel F.
AU - Harris, Tamara B.
AU - Hartikainen, Anna Liisa
AU - Heath, Simon
AU - Hirschfield, Gideon M.
AU - Hofman, Albert
AU - Homuth, Georg
AU - Hyppönen, Elina
AU - Janssen, Harry L A
AU - Johnson, Toby
AU - Kangas, Antti J.
AU - Kema, Ido P.
AU - Kühn, Jens P.
AU - Lai, Sandra
AU - Lathrop, Mark
AU - Lerch, Markus M.
AU - Li, Yun
AU - Liang, T. Jake
AU - Lin, Jing Ping
AU - Loos, Ruth J F
AU - Martin, Nicholas G.
AU - Moffatt, Miriam F.
AU - Montgomery, Grant W.
AU - Munroe, Patricia B.
AU - Musunuru, Kiran
AU - Nakamura, Yusuke
AU - O'Donnell, Christopher J.
AU - Olafsson, Isleifur
AU - Penninx, Brenda W.
AU - Pouta, Anneli
AU - Prins, Bram P.
AU - Prokopenko, Inga
AU - Puls, Ralf
AU - Ruokonen, Aimo
AU - Savolainen, Markku J.
AU - Schlessinger, David
AU - Schouten, Jeoffrey N L
AU - Seedorf, Udo
AU - Sen-Chowdhry, Srijita
AU - Siminovitch, Katherine A.
AU - Smit, Johannes H.
AU - Spector, Timothy D.
AU - Tan, Wenting
AU - Teslovich, Tanya M.
AU - Tukiainen, Taru
AU - Uitterlinden, Andre G.
AU - Van Der Klauw, Melanie M.
AU - Vasan, Ramachandran S.
AU - Wallace, Chris
AU - Wallaschofski, Henri
AU - Wichmann, H. Erich
AU - Willemsen, Gonneke
AU - Würtz, Peter
AU - Xu, Chun
AU - Yerges-Armstrong, Laura M.
AU - Abecasis, Goncalo R.
AU - Ahmadi, Kourosh R.
AU - Boomsma, Dorret I.
AU - Caulfield, Mark
AU - Cookson, William O.
AU - Van Duijn, Cornelia M.
AU - Froguel, Philippe
AU - Matsuda, Koichi
AU - McCarthy, Mark I.
AU - Meisinger, Christa
AU - Mooser, Vincent
AU - Pietiláinen, Kirsi H.
AU - Schumann, Gunter
AU - Snieder, Harold
AU - Sternberg, Michael J E
AU - Stolk, Ronald P.
AU - Thomas, Howard C.
AU - Thorsteinsdottir, Unnur
AU - Uda, Manuela
AU - Waeber, Gérard
AU - Wareham, Nicholas J.
AU - Waterworth, Dawn M.
AU - Watkins, Hugh
AU - Whitfield, John B.
AU - Witteman, Jacqueline C M
AU - Wolffenbuttel, Bruce H R
AU - Fox, Caroline S.
AU - Ala-Korpela, Mika
AU - Stefansson, Kari
AU - Vollenweider, Peter
AU - Völzke, Henry
AU - Schadt, Eric E.
AU - Scott, James
AU - Járvelin, Marjo Riitta
AU - Elliott, Paul
AU - Kooner, Jaspal S.
AU - Järvelin, Marjo-Riitta
A2 - Voight, Benjamin F
A2 - Morris, Andrew P
A2 - Welch, Ryan P
A2 - Huth, Cornelia
A2 - McCulloch, Laura J
A2 - Wu, Guanming
A2 - Willer, Cristen J
A2 - McCarroll, Steve A
A2 - Hofmann, Oliver M
A2 - Segrè, Ayellet V
A2 - Bennett, Amanda J
A2 - Blagieva, Roza
A2 - Bonnycastle, Lori L
A2 - Bengtsson Boström, Kristina
A2 - Bravenboer, Bert
A2 - Bumpstead, Suzannah
A2 - Burtt, Noël P
A2 - Couper, David J
A2 - Elliott, Katherine S
A2 - Erdos, Michael R
A2 - Franklin, Christopher S
A2 - Ganser, Martha
A2 - Green, Todd
A2 - Griffin, Simon
A2 - Groves, Christopher J
A2 - Jackson, Anne U
A2 - Johnson, Paul R V
A2 - Kao, Wen H L
A2 - Klopp, Norman
A2 - Lauritzen, Torsten
A2 - Lieverse, Aloysius
A2 - Lindgren, Cecilia M
A2 - Marre, Michel
A2 - Midthjell, Kristian
A2 - Morken, Mario A
A2 - Nilsson, Peter
A2 - Owen, Katharine R
A2 - Perry, John R B
A2 - Petersen, Ann-Kristin
A2 - Platou, Carl
A2 - Proença, Christine
A2 - William Rayner, N
A2 - Robertson, Neil R
A2 - Sampson, Michael J
A2 - Sigurdsson, Gunnar
A2 - Strassburger, Klaus
A2 - Stringham, Heather M
A2 - Sun, Qi
A2 - van Dam, Rob M
A2 - van Haeften, Timon W
A2 - van Herpt, Thijs
A2 - van Vliet-Ostaptchouk, Jana V
A2 - Weedon, Michael N
A2 - Wijmenga, Cisca
A2 - Bergman, Richard N
A2 - Cauchi, Stephane
A2 - Collins, Francis S
A2 - Gloyn, Anna L
A2 - Hide, Winston A
A2 - Hitman, Graham A
A2 - Hunter, David J
A2 - Hveem, Kristian
A2 - Mohlke, Karen L
A2 - Morris, Andrew D
A2 - Pramstaller, Peter P
A2 - Sijbrands, Eric
A2 - Stein, Lincoln D
A2 - Walker, Mark
A2 - Watanabe, Richard M
A2 - Boehm, Bernhard O
A2 - Daly, Mark J
A2 - Hattersley, Andrew T
A2 - Hu, Frank B
A2 - Meigs, James B
A2 - Pankow, James S
A2 - Florez, Jose C
A2 - Frayling, Timothy M
A2 - Wilson, James F
A2 - Lango Allen, H
A2 - Estrada, K
A2 - Lettre, G
A2 - Berndt, S I
A2 - Weedon, M N
A2 - Rivadeneira, F
A2 - Willer, C J
A2 - Jackson, A U
A2 - Vedantam, S
A2 - Ferreira, T
A2 - Wood, A R
A2 - Weyant, R J
A2 - Segrè, A V
A2 - Wheeler, E
A2 - Soranzo, N
A2 - Park, J H
A2 - Yang, J
A2 - Qi, L
A2 - Mägi, R
A2 - Pastinen, T
A2 - Heid, I M
A2 - Winkler, T W
A2 - Goddard, M E
A2 - Sin Lo, K
A2 - Palmer, C
A2 - Workalemahu, T
A2 - Aulchenko, Y S
A2 - Johansson, A
A2 - Zillikens, M C
A2 - Feitosa, M F
A2 - Esko, T
A2 - Ketkar, S
A2 - Kraft, P
A2 - Mangino, M
A2 - Absher, D
A2 - Albrecht, E
A2 - Ernst, F
A2 - Glazer, N L
A2 - Hayward, C
A2 - Jacobs, K B
A2 - Knowles, J W
A2 - Kutalik, Z
A2 - Monda, K L
A2 - Polasek, O
A2 - Preuss, M
A2 - Rayner, N W
A2 - Robertson, N R
A2 - Steinthorsdottir, V
A2 - Tyrer, J P
A2 - Voight, B F
A2 - Wiklund, F
A2 - Xu, J
A2 - Nyholt, D R
A2 - Pellikka, N
A2 - Perola, M
A2 - Perry, J R
A2 - Surakka, I
A2 - Tammesoo, M L
A2 - Altmaier, E L
A2 - Amin, N
A2 - Aspelund, T
A2 - Bhangale, T
A2 - Boucher, G
A2 - Chasman, D I
A2 - Chen, C
A2 - Cooper, M N
A2 - Gibson, Q
A2 - Grundberg, E
A2 - Hao, K
A2 - Juhani Junttila, M
A2 - Kaplan, L M
A2 - Kettunen, J
A2 - König, I R
A2 - Kwan, T
A2 - Lawrence, R W
A2 - Levinson, D F
A2 - Lorentzon, M
A2 - McKnight, B
A2 - Morris, A P
A2 - Müller, M
A2 - Suh Ngwa, J
A2 - Purcell, S
A2 - Rafelt, S
A2 - Salem, R M
A2 - Salvi, E
A2 - Shi, J
A2 - Sovio, U
A2 - Thompson, J R
A2 - Turchin, M C
A2 - Vandenput, L
A2 - Verlaan, D J
A2 - Vitart, V
A2 - White, C C
A2 - Ziegler, A
A2 - Almgren, P
A2 - Balmforth, A J
A2 - Campbell, H
A2 - Citterio, L
A2 - De Grandi, A
A2 - Dominiczak, A
A2 - Duan, J
A2 - Elosua, R
A2 - Eriksson, J G
A2 - Freimer, N B
A2 - Glorioso, N
A2 - Haiqing, S
A2 - Havulinna, A S
A2 - Hicks, A A
A2 - Hui, J
A2 - Igl, W
A2 - Illig, T
A2 - Jula, A
A2 - Kajantie, E
A2 - Kilpeläinen, T O
A2 - Koiranen, M
A2 - Kolcic, I
A2 - Koskinen, S
A2 - Kovacs, P
A2 - Laitinen, J
A2 - Liu, J
A2 - Lokki, M L
A2 - Marusic, A
A2 - Maschio, A
A2 - Meitinger, T
A2 - Mulas, A
A2 - Paré, G
A2 - Parker, A N
A2 - Petersmann, A
A2 - Pichler, I
A2 - Ridderstråle, M
A2 - Rotter, J I
A2 - Sambrook, J G
A2 - Sanders, A R
A2 - Schmidt, C Oliver
A2 - Sinisalo, J
A2 - Stringham, H M
A2 - Widen, E
A2 - Wild, S H
A2 - Zagato, L
A2 - Zgaga, L
A2 - Zitting, P
A2 - Alavere, H
A2 - Nelis, M
A2 - Peters, M J
A2 - Ripatti, S
A2 - van Meurs, J B
A2 - Aben, K K
A2 - Ardlie, K G
A2 - Beckmann, J S
A2 - Beilby, J P
A2 - Bergman, R N
A2 - Bergmann, S
A2 - Collins, F S
A2 - Cusi, D
A2 - den Heijer, M
A2 - Eiriksdottir, G
A2 - Gejman, P V
A2 - Hamsten, A
A2 - Huikuri, H V
A2 - Iribarren, C
A2 - Kähönen, M
A2 - Kaprio, J
A2 - Kathiresan, S
A2 - Kiemeney, L
A2 - Kocher, T
A2 - Launer, L J
A2 - Lehtimäki, T
A2 - Melander, O
A2 - Mosley, T H
A2 - Musk, A W
A2 - Nieminen, M S
A2 - Ohlsson, C
A2 - Oostra, B
A2 - Palmer, L J
A2 - Raitakari, O
A2 - Ridker, P M
A2 - Rioux, J D
A2 - Rissanen, A
A2 - Rivolta, C
A2 - Schunkert, H
A2 - Shuldiner, A R
A2 - Siscovick, D S
A2 - Stumvoll, M
A2 - Tönjes, A
A2 - Tuomilehto, J
A2 - van Ommen, G J
A2 - Viikari, J
A2 - Heath, A C
A2 - Province, M A
A2 - Kayser, M
A2 - Arnold, A M
A2 - Boerwinkle, E
A2 - Chanock, S J
A2 - Deloukas, P
A2 - Grönberg, H
A2 - Hall, P
A2 - Hattersley, A T
A2 - Hengstenberg, C
A2 - Hoffman, W
A2 - Salomaa, V
A2 - Schreiber, S
A2 - Wright, A F
A2 - Assimes, T L
A2 - Mohlke, K L
A2 - Erdmann, J
A2 - Gudnason, V
A2 - Gyllensten, U
A2 - Hayes, R B
A2 - Ouwehand, W H
A2 - Pramstaller, P P
A2 - Quertermous, T
A2 - Rudan, I
A2 - Samani, N J
A2 - Wilson, J F
A2 - Groop, L C
A2 - Haritunians, T
A2 - Hu, F B
A2 - Kaplan, R C
A2 - Metspalu, A
A2 - North, K E
A2 - Hunter, D J
A2 - Strachan, D P
A2 - Peltonen, L
A2 - Visscher, P M
A2 - Chatterjee, N
A2 - Boehnke, M
A2 - Ingelsson, E
A2 - Lindgren, C M
A2 - Frayling, T M
A2 - Hirschhorn, J N
A2 - Smith, A V
A2 - Edmondson, A C
A2 - Stylianou, I M
A2 - Koseki, M
A2 - Pirruccello, J P
A2 - Johansen, C T
A2 - Fouchier, S W
A2 - Isaacs, A
A2 - Peloso, G M
A2 - Barbalic, M
A2 - Ricketts, S L
A2 - Bis, J C
A2 - Orho-Melander, M
A2 - Guo, X
A2 - Li, M
A2 - Cho, Y Shin
A2 - Go, M Jin
A2 - Kim, Y Jin
A2 - Lee, J Y
A2 - Park, T
A2 - Kim, K
A2 - Sim, X
A2 - Ong, R Twee-Hee
A2 - Croteau-Chonka, D C
A2 - Lange, L A
A2 - Smith, J D
A2 - Song, K
A2 - Lamina, C
A2 - Zee, R Y
A2 - Tanaka, T
A2 - Silander, K
A2 - Sijbrands, E J
A2 - Scuteri, A
A2 - Salomaa, J
A2 - Sabatti, C
A2 - Rose, L M
A2 - Roberts, R
A2 - Rieder, M
A2 - Psaty, B M
A2 - Pedersen, N L
A2 - Pattaro, C
A2 - Pare, G
A2 - Oostra, B A
A2 - Nickerson, D A
A2 - McPherson, R
A2 - McArdle, W
A2 - Masson, D
A2 - Marroni, F
A2 - Magnusson, P K
A2 - Lucas, G
A2 - Luben, R
A2 - Langenberg, C
A2 - Lakatta, E G
A2 - Laaksonen, R
A2 - Kyvik, K O
A2 - Kronenberg, F
A2 - Khaw, K T
A2 - Janssens, A C
A2 - Hovingh, G Kees
A2 - Hastie, N D
A2 - Hall, A S
A2 - Guiducci, C
A2 - Gonzalez, E
A2 - Gieger, N B
A2 - Ferrucci, L
A2 - Ejebe, K G
A2 - Dominiczak, A F
A2 - Demissie, S
A2 - de Faire, U
A2 - Crawford, G
A2 - Chen, Y D
A2 - Burtt, N P
A2 - Bonnycastle, L L
A2 - Boekholdt, S M
A2 - Bandinelli, S
A2 - Ballantyne, C M
A2 - Ballantyne, T L
A2 - Altshuler, D
A2 - Seielstad, M
A2 - Wong, T Y
A2 - Tai, E S
A2 - Feranil, A B
A2 - Kuzawa, C W
A2 - Adair, L S
A2 - Taylor, H A
A2 - Gabriel, S B
A2 - Wilson, J G
A2 - Krauss, R M
A2 - Ordovas, J M
A2 - Tall, A R
A2 - Hegele, R A
A2 - Kastelein, J J
A2 - Reilly, M P
A2 - Cupples, L A
A2 - Rader, D J
A2 - Hernaez, Ruben
A2 - Kim, Lauren J
A2 - Palmer, Cameron D
A2 - Gudnason, Vilmundur
A2 - Eiriksdottir, Gudny
A2 - Nalls, Michael A
A2 - Clark, Jeanne M
A2 - Mitchell, Braxton D
A2 - Shuldiner, Alan R
A2 - Butler, Johannah L
A2 - Tomas, Marta
A2 - Hoffmann, Udo
A2 - Hwang, Shih-Jen
A2 - Massaro, Joseph M
A2 - Sahani, Dushyant V
A2 - Salomaa, Veikko
A2 - Schwartz, Stephen M
A2 - Siscovick, David S
A2 - Carr, J Jeffrey
A2 - Feitosa, Mary F
A2 - Smith, Albert V
A2 - Hirschhorn, Joel N
A2 - Johnson, Andrew D
A2 - Chasman, Daniel I
A2 - Tobin, Martin D
A2 - Verwoert, Germaine C
A2 - Pihur, Vasyl
A2 - Bragg-Gresham, Jennifer L
A2 - Teumer, Alexander
A2 - Glazer, Nicole L
A2 - Launer, Lenore
A2 - Zhao, Jing Hua
A2 - Aulchenko, Yurii
A2 - Sober, Siim
A2 - Parsa, Afshin
A2 - Arora, Pankaj
A2 - Zhang, Feng
A2 - Lucas, Gavin
A2 - Hicks, Andrew A
A2 - Tanaka, Toshiko
A2 - Wild, Sarah H
A2 - Igl, Wilmar
A2 - Milaneschi, Yuri
A2 - Parker, Alex N
A2 - Fava, Cristiano
A2 - Fox, Ervin R
A2 - Go, Min Jin
A2 - Kao, Wen Hong Linda
A2 - Sjogren, Marketa
A2 - Vinay, D G
A2 - Alexander, Myriam
A2 - Tabara, Yasuharu
A2 - Shaw-Hawkins, Sue
A2 - Whincup, Peter H
A2 - Liu, Yongmei
A2 - Shi, Gang
A2 - Tayo, Bamidele
A2 - Seielstad, Mark
A2 - Sim, Xueling
A2 - Nguyen, Khanh-Dung Hoang
A2 - Lehtimaki, Terho
A2 - Matullo, Giuseppe
A2 - Wu, Ying
A2 - Gaunt, Tom R
A2 - Onland-Moret, N Charlotte
A2 - Cooper, Matthew N
A2 - Platou, Carl G P
A2 - Org, Elin
A2 - Hardy, Rebecca
A2 - Dahgam, Santosh
A2 - Palmen, Jutta
A2 - Vitart, Veronique
A2 - Braund, Peter S
A2 - Kuznetsova, Tatiana
A2 - Uiterwaal, Cuno S P M
A2 - Adeyemo, Adebowale
A2 - Palmas, Walter
A2 - Ludwig, Barbara
A2 - Tomaszewski, Maciej
A2 - Tzoulaki, Ioanna
A2 - Palmer, Nicholette D
A2 - Aspelund, Thor
A2 - Garcia, Melissa
A2 - Chang, Yen-Pei C
A2 - O'Connell, Jeffrey R
A2 - Steinle, Nanette I
A2 - Grobbee, Diederick E
A2 - Arking, Dan E
A2 - Kardia, Sharon L
A2 - Morrison, Alanna C
A2 - Hernandez, Dena
A2 - Najjar, Samer
A2 - McArdle, Wendy L
A2 - Hadley, David
A2 - Connell, John M
A2 - Hingorani, Aroon D
A2 - Day, Ian N M
A2 - Lawlor, Debbie A
A2 - Beilby, John P
A2 - Lawrence, Robert W
A2 - Collins, Rory
A2 - Hopewell, Jemma C
A2 - Ongen, Halit
A2 - Dreisbach, Albert W
A2 - Li, Yali
A2 - Young, J H
A2 - Bis, Joshua C
A2 - Kahonen, Mika
A2 - Viikari, Jorma
A2 - Adair, Linda S
A2 - Lee, Nanette R
A2 - Chen, Ming-Huei
A2 - Olden, Matthias
A2 - Pattaro, Cristian
A2 - Bolton, Judith A Hoffman
A2 - Kottgen, Anna
A2 - Bergmann, Sven
A2 - Chaturvedi, Nish R
A2 - Islam, Muhammad
A2 - Jafar, Tazeen H
A2 - Erdmann, Jeanette
A2 - Kulkarni, Smita R
A2 - Bornstein, Stefan R
A2 - Grassler, Jurgen
A2 - Kettunen, Johannes
A2 - Howard, Philip
A2 - Taylor, Andrew
A2 - Guarrera, Simonetta
A2 - Ricceri, Fulvio
A2 - Emilsson, Valur
A2 - Plump, Andrew
A2 - Barroso, Ines
A2 - Khaw, Kay-Tee
A2 - Weder, Alan B
A2 - Hunt, Steven C
A2 - Sun, Yan V
A2 - Peltonen, Leena
A2 - Perola, Markus
A2 - Vartiainen, Erkki
A2 - Brand, Stefan-Martin
A2 - Staessen, Jan A
A2 - Wang, Thomas J
A2 - Burton, Paul R
A2 - Artigas, Maria Soler
A2 - Dong, Yanbin
A2 - Wang, Xiaoling
A2 - Zhu, Haidong
A2 - Lohman, Kurt K
A2 - Rudock, Megan E
A2 - Heckbert, Susan R
A2 - Smith, Nicholas L
A2 - Wiggins, Kerri L
A2 - Doumatey, Ayo
A2 - Shriner, Daniel
A2 - Veldre, Gudrun
A2 - Viigimaa, Margus
A2 - Kinra, Sanjay
A2 - Prabhakaran, Dorairajan
A2 - Tripathy, Vikal
A2 - Langefeld, Carl D
A2 - Rosengren, Annika
A2 - Thelle, Dag S
A2 - Corsi, Anna Maria
A2 - Forrester, Terrence
A2 - Hilton, Gina
A2 - McKenzie, Colin A
A2 - Salako, Tunde
A2 - Iwai, Naoharu
A2 - Kita, Yoshikuni
A2 - Ogihara, Toshio
A2 - Ohkubo, Takayoshi
A2 - Okamura, Tomonori
A2 - Ueshima, Hirotsugu
A2 - Umemura, Satoshi
A2 - Eyheramendy, Susana
A2 - Cho, Yoon Shin
A2 - Kim, Hyung-Lae
A2 - Lee, Jong-Young
A2 - Hedblad, Bo
A2 - Smith, George Davey
A2 - Wong, Andrew
A2 - Stančakova, Alena
A2 - Raffel, Leslie J
A2 - Yao, Jie
A2 - Kathiresan, Sekar
A2 - Schwartz, Steven M
A2 - Ikram, M Arfan
A2 - Longstreth, Will T
A2 - Mosley, Thomas H
A2 - Seshadri, Sudha
A2 - Shrine, Nick R G
A2 - Wain, Louise V
A2 - Laitinen, Jaana
A2 - Zitting, Paavo
A2 - Cooper, Jackie A
A2 - Humphries, Steve E
A2 - Danesh, John
A2 - Rasheed, Asif
A2 - Hamsten, Anders
A2 - Bakker, Stephan J L
A2 - van Gilst, Wiek H
A2 - Janipalli, Charles S
A2 - Mani, K Radha
A2 - Yajnik, Chittaranjan S
A2 - Mattace-Raso, Francesco U S
A2 - Oostra, Ben A
A2 - Demirkan, Ayse
A2 - Isaacs, Aaron
A2 - Rivadeneira, Fernando
A2 - Lakatta, Edward G
A2 - Orru, Marco
A2 - Scuteri, Angelo
A2 - Lyytikainen, Leo-Pekka
A2 - Wurz, Peter
A2 - Ong, Rick Twee-Hee
A2 - Dorr, Marcus
A2 - Kroemer, Heyo K
A2 - Volker, Uwe
A2 - Volzke, Henry
A2 - Deloukas, Panos
A2 - Mangino, Massimo
A2 - Meschia, James F
A2 - Sharma, Pankaj
A2 - Terzic, Janos
A2 - Kumar, M J Kranthi
A2 - Denniff, Matthew
A2 - Zukowska-Szczechowska, Ewa
A2 - Wagenknecht, Lynne E
A2 - Fowkes, F Gerald R
A2 - Charchar, Fadi J
A2 - Hayward, Caroline
A2 - Guo, Xiuqing
A2 - Rotimi, Charles
A2 - Bots, Michiel L
A2 - Brand, Eva
A2 - Samani, Nilesh J
A2 - Polasek, Ozren
A2 - Talmud, Philippa J
A2 - Nyberg, Fredrik
A2 - Kuh, Diana
A2 - Laan, Maris
A2 - Palmer, Lyle J
A2 - van der Schouw, Yvonne T
A2 - Casas, Juan P
A2 - Vineis, Paolo
A2 - Raitakari, Olli
A2 - Ganesh, Santhi K
A2 - Wong, Tien Y
A2 - Tai, E Shyong
A2 - Cooper, Richard S
A2 - Rao, Dabeeru C
A2 - Morris, Richard W
A2 - Dominiczak, Anna F
A2 - Miki, Tetsuro
A2 - Saleheen, Danish
A2 - Chandak, Giriraj R
A2 - Coresh, Josef
A2 - Navis, Gerjan
A2 - Han, Bok-Ghee
A2 - Zhu, Xiaofeng
A2 - Melander, Olle
A2 - Ridker, Paul M
A2 - Bandinelli, Stefania
A2 - Gyllensten, Ulf B
A2 - Wright, Alan F
A2 - Ferrucci, Luigi
A2 - Elosua, Roberto
A2 - Soranzo, Nicole
A2 - Sijbrands, Eric J G
A2 - Rotter, Jerome I
A2 - Rettig, Rainer
A2 - Strachan, David P
A2 - Beckmann, Jacques S
A2 - Larson, Martin G
A2 - Psaty, Bruce M
A2 - Chakravarti, Aravinda
A2 - Newton-Cheh, Christopher
A2 - Levy, Daniel
A2 - Dupuis, J
A2 - Saxena, R
A2 - Bouatia-Naji, N
A2 - Gloyn, A L
A2 - Randall, J
A2 - Rybin, D
A2 - Henneman, P
A2 - Grallert, H
A2 - Dehghan, A
A2 - Franklin, C S
A2 - Navarro, P
A2 - Goel, A
A2 - Egan, J M
A2 - Lajunen, T
A2 - Grarup, N
A2 - Sparsø, T
A2 - Doney, A
A2 - Kanoni, S
A2 - Shrader, P
A2 - Cavalcanti-Proença, C
A2 - Kumari, M
A2 - Timpson, N J
A2 - Zabena, C
A2 - Rocheleau, G
A2 - An, P
A2 - O'Connell, J
A2 - Elliott, A
A2 - McCarroll, S A
A2 - Payne, F
A2 - Roccasecca, R M
A2 - Pattou, F
A2 - Sethupathy, P
A2 - Ardlie, K
A2 - Ariyurek, Y
A2 - Balkau, B
A2 - Barter, P
A2 - Ben-Shlomo, Y
A2 - Benediktsson, R
A2 - Bennett, A J
A2 - Bochud, M
A2 - Bonnefond, A
A2 - Borch-Johnsen, K
A2 - Böttcher, Y
A2 - Brunner, E
A2 - Bumpstead, S J
A2 - Charpentier, G
A2 - Chines, P
A2 - Clarke, R
A2 - Cornelis, M
A2 - Crisponi, L
A2 - Day, I N
A2 - Delplanque, J
A2 - Dina, C
A2 - Erdos, M R
A2 - Fedson, A C
A2 - Fischer-Rosinsky, A
A2 - Frants, R
A2 - Franzosi, M G
A2 - Galan, P
A2 - Goodarzi, M O
A2 - Graessler, J
A2 - Groves, C J
A2 - Grundy, S
A2 - Gwilliam, R
A2 - Hadjadj, S
A2 - Hallmans, G
A2 - Hammond, N
A2 - Han, X
A2 - Hassanali, N
A2 - Hercberg, S
A2 - Herder, C
A2 - Hillman, D R
A2 - Hingorani, A D
A2 - Hung, J
A2 - Isomaa, B
A2 - Johnson, P R
A2 - Jørgensen, T
A2 - Kaakinen, M
A2 - Kesaniemi, Y A
A2 - Kivimaki, M
A2 - Knight, B
A2 - Lawlor, D A
A2 - Le Bacquer, O
A2 - Lecoeur, C
A2 - Lyssenko, V
A2 - Mahley, R
A2 - Manning, A K
A2 - Martínez-Larrad, M T
A2 - McAteer, J B
A2 - McCulloch, L J
A2 - Melzer, D
A2 - Meyre, D
A2 - Mitchell, B D
A2 - Morken, M A
A2 - Mukherjee, S
A2 - Naitza, S
A2 - Narisu, N
A2 - Neville, M J
A2 - Orrù, M
A2 - Pakyz, R
A2 - Palmer, C N
A2 - Paolisso, G
A2 - Pearson, D
A2 - Pfeiffer, A F
A2 - Posthuma, D
A2 - Potter, S C
A2 - Rathmann, W
A2 - Rice, K
A2 - Roden, M
A2 - Rolandsson, O
A2 - Sandbaek, A
A2 - Sandhu, M
A2 - Sayer, A A
A2 - Scheet, P
A2 - Sharp, S J
A2 - Shields, B
A2 - Sigurethsson, G
A2 - Silveira, A
A2 - Simpson, L
A2 - Singleton, A
A2 - Smith, N L
A2 - Swift, A
A2 - Syddall, H
A2 - Syvänen, A C
A2 - Thorand, B
A2 - Tichet, J
A2 - Tuomi, T
A2 - van Dijk, K W
A2 - van Hoek, M
A2 - Varma, D
A2 - Visvikis-Siest, S
A2 - Vogelzangs, N
A2 - Wagner, P J
A2 - Walley, A
A2 - Walters, G B
A2 - Ward, K L
A2 - Yarnell, J W
A2 - Zeggini, E
A2 - Zelenika, D
A2 - Zethelius, B
A2 - Zhai, G
A2 - Zhao, J H
A2 - Meneton, P
A2 - Nathan, D M
A2 - Williams, G H
A2 - Smith, G D
A2 - Bornstein, S R
A2 - Schwarz, P
A2 - Spranger, J
A2 - Karpe, F
A2 - Cooper, C
A2 - Dedoussis, G V
A2 - Serrano-Ríos, M
A2 - Morris, A D
A2 - Lind, L
A2 - Franks, P W
A2 - Ebrahim, S
A2 - Marmot, M
A2 - Kao, W H
A2 - Pankow, J S
A2 - Sampson, M J
A2 - Kuusisto, J
A2 - Laakso, M
A2 - Hansen, T
A2 - Pedersen, O
A2 - Buchanan, T A
A2 - Valle, T T
A2 - Kong, A
A2 - Cao, A
A2 - Sladek, R
A2 - Watanabe, R M
A2 - Meigs, J B
A2 - Groop, L
A2 - Florez, J C
A2 - Barroso, Inês
N1 - K05 AA017688, NIAAA NIH HHS, United States
PY - 2011/11
Y1 - 2011/11
N2 - Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10 -8 to P = 10 -190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function. © 2011 Nature America, Inc. All rights reserved.
AB - Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10 -8 to P = 10 -190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function. © 2011 Nature America, Inc. All rights reserved.
U2 - 10.1038/ng.970
DO - 10.1038/ng.970
M3 - Article
C2 - 22001757
SN - 1061-4036
VL - 43
SP - 1131
EP - 1138
JO - Nature Genetics
JF - Nature Genetics
IS - 11
ER -