Genome-wide association study identifies new prostate cancer susceptibility loci

Fredrick R. Schumacher; Sonja I. Berndt; Afshan Siddiq; Kevin B. Jacobs; Zhaoming Wang; Sara Lindstrom; Victoria L. Stevens; Constance Chen; Alison M. Mondul; Ruth C. Travis; Daniel O. Stram; Rosalind A. Eeles; Douglas F. Easton; Graham Giles; John L. Hopper; David E. Neal; Freddie C. Hamdy; Jenny L. Donovan; Kenneth Muir; Ali Amin Al Olama; Zsofia Kote-Jarai; Michelle Guy; Gianluca Severi; Henrik Grönberg; William B. Isaacs; Robert Karlsson; Fredrik Wiklund; Jianfeng Xu; Naomi E. Allen; Gerald L. Andriole; Aurelio Barricarte; Heiner Boeing; H. Bas Bueno-de-Mesquita; E. David Crawford; W. Ryan Diver; Carlos A. Gonzalez; J. Michael Gaziano; Edward L. Giovannucci; Mattias Johansson; Loic Le Marchand; Jing Ma; Sabina Sieri; Pär Stattin; Meir J. Stampfer; Anne Tjonneland; Paolo Vineis; Jarmo Virtamo; Ulla Vogel; Stephanie J. Weinstein; Meredith Yeager; Michael J. Thun; Laurence N. Kolonel; Brian E. Henderson; Demetrius Albanes; Richard B. Hayes; Heather Spencer Feigelson; Elio Riboli; David J. Hunter; Stephen J. Chanock; Christopher A. Haiman; Peter Kraft

doi:10.1093/hmg/ddr295

Genome-wide association study identifies new prostate cancer susceptibility loci

Fredrick R. Schumacher, Sonja I. Berndt, Afshan Siddiq, Kevin B. Jacobs, Zhaoming Wang, Sara Lindstrom, Victoria L. Stevens, Constance Chen, Alison M. Mondul, Ruth C. Travis, Daniel O. Stram, Rosalind A. Eeles, Douglas F. Easton, Graham Giles, John L. Hopper, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Kenneth Muir, Ali Amin Al OlamaZsofia Kote-Jarai, Michelle Guy, Gianluca Severi, Henrik Grönberg, William B. Isaacs, Robert Karlsson, Fredrik Wiklund, Jianfeng Xu, Naomi E. Allen, Gerald L. Andriole, Aurelio Barricarte, Heiner Boeing, H. Bas Bueno-de-Mesquita, E. David Crawford, W. Ryan Diver, Carlos A. Gonzalez, J. Michael Gaziano, Edward L. Giovannucci, Mattias Johansson, Loic Le Marchand, Jing Ma, Sabina Sieri, Pär Stattin, Meir J. Stampfer, Anne Tjonneland, Paolo Vineis, Jarmo Virtamo, Ulla Vogel, Stephanie J. Weinstein, Meredith Yeager, Michael J. Thun, Laurence N. Kolonel, Brian E. Henderson, Demetrius Albanes, Richard B. Hayes, Heather Spencer Feigelson, Elio Riboli, David J. Hunter, Stephen J. Chanock, Christopher A. Haiman, Peter Kraft

Research output: Contribution to journal › Article › peer-review

Abstract

Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P <0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 × 10 -8). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 × 10 -9). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P 5 0.72 and P 5 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes. © The Author 2011. Published by Oxford University Press. All rights reserved.

Original language	English
Article number	ddr295
Pages (from-to)	3867-3875
Number of pages	8
Journal	Human Molecular Genetics
Volume	20
Issue number	19
DOIs	https://doi.org/10.1093/hmg/ddr295
Publication status	Published - Oct 2011

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10.1093/hmg/ddr295

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Schumacher, F. R., Berndt, S. I., Siddiq, A., Jacobs, K. B., Wang, Z., Lindstrom, S., Stevens, V. L., Chen, C., Mondul, A. M., Travis, R. C., Stram, D. O., Eeles, R. A., Easton, D. F., Giles, G., Hopper, J. L., Neal, D. E., Hamdy, F. C., Donovan, J. L., Muir, K., ... Kraft, P. (2011). Genome-wide association study identifies new prostate cancer susceptibility loci. Human Molecular Genetics, 20(19), 3867-3875. Article ddr295. https://doi.org/10.1093/hmg/ddr295

@article{e7685e28ddb1494f9f108dc95a578862,

title = "Genome-wide association study identifies new prostate cancer susceptibility loci",

abstract = "Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P <0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 × 10 -8). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 × 10 -9). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P 5 0.72 and P 5 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes. {\textcopyright} The Author 2011. Published by Oxford University Press. All rights reserved.",

author = "Schumacher, {Fredrick R.} and Berndt, {Sonja I.} and Afshan Siddiq and Jacobs, {Kevin B.} and Zhaoming Wang and Sara Lindstrom and Stevens, {Victoria L.} and Constance Chen and Mondul, {Alison M.} and Travis, {Ruth C.} and Stram, {Daniel O.} and Eeles, {Rosalind A.} and Easton, {Douglas F.} and Graham Giles and Hopper, {John L.} and Neal, {David E.} and Hamdy, {Freddie C.} and Donovan, {Jenny L.} and Kenneth Muir and {Al Olama}, {Ali Amin} and Zsofia Kote-Jarai and Michelle Guy and Gianluca Severi and Henrik Gr{\"o}nberg and Isaacs, {William B.} and Robert Karlsson and Fredrik Wiklund and Jianfeng Xu and Allen, {Naomi E.} and Andriole, {Gerald L.} and Aurelio Barricarte and Heiner Boeing and Bueno-de-Mesquita, {H. Bas} and Crawford, {E. David} and Diver, {W. Ryan} and Gonzalez, {Carlos A.} and Gaziano, {J. Michael} and Giovannucci, {Edward L.} and Mattias Johansson and {Le Marchand}, Loic and Jing Ma and Sabina Sieri and P{\"a}r Stattin and Stampfer, {Meir J.} and Anne Tjonneland and Paolo Vineis and Jarmo Virtamo and Ulla Vogel and Weinstein, {Stephanie J.} and Meredith Yeager and Thun, {Michael J.} and Kolonel, {Laurence N.} and Henderson, {Brian E.} and Demetrius Albanes and Hayes, {Richard B.} and Feigelson, {Heather Spencer} and Elio Riboli and Hunter, {David J.} and Chanock, {Stephen J.} and Haiman, {Christopher A.} and Peter Kraft",

year = "2011",

month = oct,

doi = "10.1093/hmg/ddr295",

language = "English",

volume = "20",

pages = "3867--3875",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "19",

}

Schumacher, FR, Berndt, SI, Siddiq, A, Jacobs, KB, Wang, Z, Lindstrom, S, Stevens, VL, Chen, C, Mondul, AM, Travis, RC, Stram, DO, Eeles, RA, Easton, DF, Giles, G, Hopper, JL, Neal, DE, Hamdy, FC, Donovan, JL, Muir, K, Al Olama, AA, Kote-Jarai, Z, Guy, M, Severi, G, Grönberg, H, Isaacs, WB, Karlsson, R, Wiklund, F, Xu, J, Allen, NE, Andriole, GL, Barricarte, A, Boeing, H, Bueno-de-Mesquita, HB, Crawford, ED, Diver, WR, Gonzalez, CA, Gaziano, JM, Giovannucci, EL, Johansson, M, Le Marchand, L, Ma, J, Sieri, S, Stattin, P, Stampfer, MJ, Tjonneland, A, Vineis, P, Virtamo, J, Vogel, U, Weinstein, SJ, Yeager, M, Thun, MJ, Kolonel, LN, Henderson, BE, Albanes, D, Hayes, RB, Feigelson, HS, Riboli, E, Hunter, DJ, Chanock, SJ, Haiman, CA & Kraft, P 2011, 'Genome-wide association study identifies new prostate cancer susceptibility loci', Human Molecular Genetics, vol. 20, no. 19, ddr295, pp. 3867-3875. https://doi.org/10.1093/hmg/ddr295

TY - JOUR

T1 - Genome-wide association study identifies new prostate cancer susceptibility loci

AU - Schumacher, Fredrick R.

AU - Berndt, Sonja I.

AU - Siddiq, Afshan

AU - Jacobs, Kevin B.

AU - Wang, Zhaoming

AU - Lindstrom, Sara

AU - Stevens, Victoria L.

AU - Chen, Constance

AU - Mondul, Alison M.

AU - Travis, Ruth C.

AU - Stram, Daniel O.

AU - Eeles, Rosalind A.

AU - Easton, Douglas F.

AU - Giles, Graham

AU - Hopper, John L.

AU - Neal, David E.

AU - Hamdy, Freddie C.

AU - Donovan, Jenny L.

AU - Muir, Kenneth

AU - Al Olama, Ali Amin

AU - Kote-Jarai, Zsofia

AU - Guy, Michelle

AU - Severi, Gianluca

AU - Grönberg, Henrik

AU - Isaacs, William B.

AU - Karlsson, Robert

AU - Wiklund, Fredrik

AU - Xu, Jianfeng

AU - Allen, Naomi E.

AU - Andriole, Gerald L.

AU - Barricarte, Aurelio

AU - Boeing, Heiner

AU - Bueno-de-Mesquita, H. Bas

AU - Crawford, E. David

AU - Diver, W. Ryan

AU - Gonzalez, Carlos A.

AU - Gaziano, J. Michael

AU - Giovannucci, Edward L.

AU - Johansson, Mattias

AU - Le Marchand, Loic

AU - Ma, Jing

AU - Sieri, Sabina

AU - Stattin, Pär

AU - Stampfer, Meir J.

AU - Tjonneland, Anne

AU - Vineis, Paolo

AU - Virtamo, Jarmo

AU - Vogel, Ulla

AU - Weinstein, Stephanie J.

AU - Yeager, Meredith

AU - Thun, Michael J.

AU - Kolonel, Laurence N.

AU - Henderson, Brian E.

AU - Albanes, Demetrius

AU - Hayes, Richard B.

AU - Feigelson, Heather Spencer

AU - Riboli, Elio

AU - Hunter, David J.

AU - Chanock, Stephen J.

AU - Haiman, Christopher A.

AU - Kraft, Peter

PY - 2011/10

Y1 - 2011/10

N2 - Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P <0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 × 10 -8). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 × 10 -9). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P 5 0.72 and P 5 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes. © The Author 2011. Published by Oxford University Press. All rights reserved.

AB - Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countries and the second leading cause of cancer mortality, yet little is known regarding its etiology and factors that influence clinical outcome. Genome-wide association studies (GWAS) of PrCa have identified at least 30 distinct loci associated with small differences in risk. We conducted a GWAS in 2782 advanced PrCa cases (Gleason grade ≥ 8 or tumor stage C/D) and 4458 controls with 571 243 single nucleotide polymorphisms (SNPs). Based on in silico replication of 4679 SNPs (Stage 1, P <0.02) in two published GWAS with 7358 PrCa cases and 6732 controls, we identified a new susceptibility locus associated with overall PrCa risk at 2q37.3 (rs2292884, P = 4.3 × 10 -8). We also confirmed a locus suggested by an earlier GWAS at 12q13 (rs902774, P = 8.6 × 10 -9). The estimated per-allele odds ratios for these loci (1.14 for rs2292884 and 1.17 for rs902774) did not differ between advanced and non-advanced PrCa (case-only test for heterogeneity P 5 0.72 and P 5 0.61, respectively). Further studies will be needed to assess whether these or other loci are differentially associated with PrCa subtypes. © The Author 2011. Published by Oxford University Press. All rights reserved.

U2 - 10.1093/hmg/ddr295

DO - 10.1093/hmg/ddr295

M3 - Article

SN - 0964-6906

VL - 20

SP - 3867

EP - 3875

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 19

M1 - ddr295

ER -

Genome-wide association study identifies new prostate cancer susceptibility loci

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