Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders

Frederick W. Miller; Robert G. Cooper; Jiří Vencovský; Lisa G. Rider; Katalin Danko; Lucy R. Wedderburn; Ingrid E. Lundberg; Lauren M. Pachman; Ann M. Reed; Steven R. Ytterberg; Leonid Padyukov; Albert Selva-O'Callaghan; Timothy R D J Radstake; David A. Isenberg; Hector Chinoy; William E R Ollier; Terrance P. O'Hanlon; Bo Peng; Annette Lee; Janine A. Lamb; Wei Chen; Christopher I. Amos; Peter K. Gregersen; Christopher Denton; David Hilton-Jones; Patrick Kiely; Paul H. Plotz; Mark Gourley; Paul Scheet; Hemlata Varsani

doi:10.1002/art.38137

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders

Frederick W. Miller, Robert G. Cooper, Jiří Vencovský, Lisa G. Rider, Katalin Danko, Lucy R. Wedderburn, Ingrid E. Lundberg, Lauren M. Pachman, Ann M. Reed, Steven R. Ytterberg, Leonid Padyukov, Albert Selva-O'Callaghan, Timothy R D J Radstake, David A. Isenberg, Hector Chinoy, William E R Ollier, Terrance P. O'Hanlon, Bo Peng, Annette Lee, Janine A. LambWei Chen, Christopher I. Amos, Peter K. Gregersen, Christopher Denton, David Hilton-Jones, Patrick Kiely, Paul H. Plotz, Mark Gourley, Paul Scheet, Hemlata Varsani

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Abstract

Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of

Original language	English
Pages (from-to)	3239-3247
Number of pages	8
Journal	Arthritis Care & Research
Volume	65
Issue number	12
DOIs	https://doi.org/10.1002/art.38137
Publication status	Published - Dec 2013

Keywords

adult
dermatomyositis
juvenile
shared autoimmunity genes

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Miller, F. W., Cooper, R. G., Vencovský, J., Rider, L. G., Danko, K., Wedderburn, L. R., Lundberg, I. E., Pachman, L. M., Reed, A. M., Ytterberg, S. R., Padyukov, L., Selva-O'Callaghan, A., Radstake, T. R. D. J., Isenberg, D. A., Chinoy, H., Ollier, W. E. R., O'Hanlon, T. P., Peng, B., Lee, A., ... Varsani, H. (2013). Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders. Arthritis Care & Research, 65(12), 3239-3247. https://doi.org/10.1002/art.38137

@article{30cf7c6e62534f54b7c8e45367a63873,

title = "Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders",

abstract = "Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of",

keywords = "adult, dermatomyositis, juvenile, shared autoimmunity genes",

author = "Miller, {Frederick W.} and Cooper, {Robert G.} and Ji{\v r}{\'i} Vencovsk{\'y} and Rider, {Lisa G.} and Katalin Danko and Wedderburn, {Lucy R.} and Lundberg, {Ingrid E.} and Pachman, {Lauren M.} and Reed, {Ann M.} and Ytterberg, {Steven R.} and Leonid Padyukov and Albert Selva-O'Callaghan and Radstake, {Timothy R D J} and Isenberg, {David A.} and Hector Chinoy and Ollier, {William E R} and O'Hanlon, {Terrance P.} and Bo Peng and Annette Lee and Lamb, {Janine A.} and Wei Chen and Amos, {Christopher I.} and Gregersen, {Peter K.} and Christopher Denton and David Hilton-Jones and Patrick Kiely and Plotz, {Paul H.} and Mark Gourley and Paul Scheet and Hemlata Varsani",

year = "2013",

month = dec,

doi = "10.1002/art.38137",

language = "English",

volume = "65",

pages = "3239--3247",

journal = "Arthritis Care & Research",

issn = "2151-464X",

publisher = "John Wiley & Sons Ltd",

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Miller, FW, Cooper, RG, Vencovský, J, Rider, LG, Danko, K, Wedderburn, LR, Lundberg, IE, Pachman, LM, Reed, AM, Ytterberg, SR, Padyukov, L, Selva-O'Callaghan, A, Radstake, TRDJ, Isenberg, DA, Chinoy, H , Ollier, WER, O'Hanlon, TP, Peng, B, Lee, A, Lamb, JA, Chen, W, Amos, CI, Gregersen, PK, Denton, C, Hilton-Jones, D, Kiely, P, Plotz, PH, Gourley, M, Scheet, P & Varsani, H 2013, 'Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders', Arthritis Care & Research, vol. 65, no. 12, pp. 3239-3247. https://doi.org/10.1002/art.38137

TY - JOUR

T1 - Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders

AU - Miller, Frederick W.

AU - Cooper, Robert G.

AU - Vencovský, Jiří

AU - Rider, Lisa G.

AU - Danko, Katalin

AU - Wedderburn, Lucy R.

AU - Lundberg, Ingrid E.

AU - Pachman, Lauren M.

AU - Reed, Ann M.

AU - Ytterberg, Steven R.

AU - Padyukov, Leonid

AU - Selva-O'Callaghan, Albert

AU - Radstake, Timothy R D J

AU - Isenberg, David A.

AU - Chinoy, Hector

AU - Ollier, William E R

AU - O'Hanlon, Terrance P.

AU - Peng, Bo

AU - Lee, Annette

AU - Lamb, Janine A.

AU - Chen, Wei

AU - Amos, Christopher I.

AU - Gregersen, Peter K.

AU - Denton, Christopher

AU - Hilton-Jones, David

AU - Kiely, Patrick

AU - Plotz, Paul H.

AU - Gourley, Mark

AU - Scheet, Paul

AU - Varsani, Hemlata

PY - 2013/12

Y1 - 2013/12

N2 - Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of

AB - Objective: To identify new genetic associations with juvenile and adult dermatomyositis (DM). Methods: We performed a genome-wide association study (GWAS) of adult and juvenile DM patients of European ancestry (n = 1,178) and controls (n = 4,724). To assess genetic overlap with other autoimmune disorders, we examined whether 141 single-nucleotide polymorphisms (SNPs) outside the major histocompatibility complex (MHC) locus, and previously associated with autoimmune diseases, predispose to DM. Results: Compared to controls, patients with DM had a strong signal in the MHC region consisting of GWAS-level significance (P <5 × 10-8) at 80 genotyped SNPs. An analysis of 141 non-MHC SNPs previously associated with autoimmune diseases showed that 3 SNPs linked with 3 genes were associated with DM, with a false discovery rate (FDR) of

KW - adult

KW - dermatomyositis

KW - juvenile

KW - shared autoimmunity genes

U2 - 10.1002/art.38137

DO - 10.1002/art.38137

M3 - Article

C2 - 23983088

SN - 2151-464X

VL - 65

SP - 3239

EP - 3247

JO - Arthritis Care & Research

JF - Arthritis Care & Research

IS - 12

ER -

Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders

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Keywords

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