Genome-Wide Association Study of Prostate Cancer-Specific Survival

R Szulkin; R Karlsson; T Whitington; M Aly; H Gronberg; R A Eeles; D F Easton; Z Kote-Jarai; A A Al Olama; S Benlloch; K Muir; G G Giles; M C Southey; L M FitzGerald; B E Henderson; F R Schumacher; C A Haiman; C Sipeky; T L Tammela; B G Nordestgaard; T J Key; R C Travis; D E Neal; J L Donovan; F C Hamdy; P D Pharoah; N Pashayan; K T Khaw; J L Stanford; S N Thibodeau; S K McDonnell; D J Schaid; C Maier; W Vogel; M Luedeke; K Herkommer; A S Kibel; C Cybulski; J Lubinski; W Kluzniak; L Cannon-Albright; H Brenner; V Herrmann; B Holleczek; J Y Park; T A Sellers; H Y Lim; C Slavov; R P Kaneva; V I Mitev; A Spurdle; M R Teixeira; P Paulo; S Maia; H Pandha; A Michael; A Kierzek; J Batra; J A Clements; D Albanes; G L Andriole; S I Berndt; S Chanock; S M Gapstur; E L Giovannucci; D J Hunter; P Kraft; L Le Marchand; J Ma; A M Mondul; K L Penney; M J Stampfer; V L Stevens; S J Weinstein; A Trichopoulou; B H Bueno-de-Mesquita; A Tjonneland; D G Cox; L Maehle; J Schleutker; S Lindstrom; F Wiklund

doi:10.1158/1055-9965.EPI-15-0543

Genome-Wide Association Study of Prostate Cancer-Specific Survival

R Szulkin, R Karlsson, T Whitington, M Aly, H Gronberg, R A Eeles, D F Easton, Z Kote-Jarai, A A Al Olama, S Benlloch, K Muir, G G Giles, M C Southey, L M FitzGerald, B E Henderson, F R Schumacher, C A Haiman, C Sipeky, T L Tammela, B G NordestgaardT J Key, R C Travis, D E Neal, J L Donovan, F C Hamdy, P D Pharoah, N Pashayan, K T Khaw, J L Stanford, S N Thibodeau, S K McDonnell, D J Schaid, C Maier, W Vogel, M Luedeke, K Herkommer, A S Kibel, C Cybulski, J Lubinski, W Kluzniak, L Cannon-Albright, H Brenner, V Herrmann, B Holleczek, J Y Park, T A Sellers, H Y Lim, C Slavov, R P Kaneva, V I Mitev, A Spurdle, M R Teixeira, P Paulo, S Maia, H Pandha, A Michael, A Kierzek, J Batra, J A Clements, D Albanes, G L Andriole, S I Berndt, S Chanock, S M Gapstur, E L Giovannucci, D J Hunter, P Kraft, L Le Marchand, J Ma, A M Mondul, K L Penney, M J Stampfer, V L Stevens, S J Weinstein, A Trichopoulou, B H Bueno-de-Mesquita, A Tjonneland, D G Cox, L Maehle, J Schleutker, S Lindstrom, F Wiklund

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS: We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. (c)2015 AACR.

Original language	English
Pages (from-to)	1796-800
Number of pages	995
Journal	Cancer Epidemiology, Biomarkers & Prevention
Volume	24
Issue number	11
DOIs	https://doi.org/10.1158/1055-9965.EPI-15-0543
Publication status	Published - 2015

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10.1158/1055-9965.EPI-15-0543

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Szulkin, R., Karlsson, R., Whitington, T., Aly, M., Gronberg, H., Eeles, R. A., Easton, D. F., Kote-Jarai, Z., Al Olama, A. A., Benlloch, S., Muir, K., Giles, G. G., Southey, M. C., FitzGerald, L. M., Henderson, B. E., Schumacher, F. R., Haiman, C. A., Sipeky, C., Tammela, T. L., ... Wiklund, F. (2015). Genome-Wide Association Study of Prostate Cancer-Specific Survival. Cancer Epidemiology, Biomarkers & Prevention, 24(11), 1796-800. https://doi.org/10.1158/1055-9965.EPI-15-0543

@article{e2824059a46f4866b8d55fcd02be1e28,

title = "Genome-Wide Association Study of Prostate Cancer-Specific Survival",

abstract = "BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS: We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. (c)2015 AACR.",

author = "R Szulkin and R Karlsson and T Whitington and M Aly and H Gronberg and Eeles, {R A} and Easton, {D F} and Z Kote-Jarai and {Al Olama}, {A A} and S Benlloch and K Muir and Giles, {G G} and Southey, {M C} and FitzGerald, {L M} and Henderson, {B E} and Schumacher, {F R} and Haiman, {C A} and C Sipeky and Tammela, {T L} and Nordestgaard, {B G} and Key, {T J} and Travis, {R C} and Neal, {D E} and Donovan, {J L} and Hamdy, {F C} and Pharoah, {P D} and N Pashayan and Khaw, {K T} and Stanford, {J L} and Thibodeau, {S N} and McDonnell, {S K} and Schaid, {D J} and C Maier and W Vogel and M Luedeke and K Herkommer and Kibel, {A S} and C Cybulski and J Lubinski and W Kluzniak and L Cannon-Albright and H Brenner and V Herrmann and B Holleczek and Park, {J Y} and Sellers, {T A} and Lim, {H Y} and C Slavov and Kaneva, {R P} and Mitev, {V I} and A Spurdle and Teixeira, {M R} and P Paulo and S Maia and H Pandha and A Michael and A Kierzek and J Batra and Clements, {J A} and D Albanes and Andriole, {G L} and Berndt, {S I} and S Chanock and Gapstur, {S M} and Giovannucci, {E L} and Hunter, {D J} and P Kraft and {Le Marchand}, L and J Ma and Mondul, {A M} and Penney, {K L} and Stampfer, {M J} and Stevens, {V L} and Weinstein, {S J} and A Trichopoulou and Bueno-de-Mesquita, {B H} and A Tjonneland and Cox, {D G} and L Maehle and J Schleutker and S Lindstrom and F Wiklund",

note = "Szulkin, Robert Karlsson, Robert Whitington, Thomas Aly, Markus Gronberg, Henrik Eeles, Rosalind A Easton, Douglas F Kote-Jarai, Zsofia Al Olama, Ali Amin Benlloch, Sara Muir, Kenneth Giles, Graham G Southey, Melissa C FitzGerald, Liesel M Henderson, Brian E Schumacher, Fredrick R Haiman, Christopher A Sipeky, Csilla Tammela, Teuvo L J Nordestgaard, Borge G Key, Timothy J Travis, Ruth C Neal, David E Donovan, Jenny L Hamdy, Freddie C Pharoah, Paul D P Pashayan, Nora Khaw, Kay-Tee Stanford, Janet L Thibodeau, Stephen N McDonnell, Shannon K Schaid, Daniel J Maier, Christiane Vogel, Walther Luedeke, Manuel Herkommer, Kathleen Kibel, Adam S Cybulski, Cezary Lubinski, Jan Kluzniak, Wojciech Cannon-Albright, Lisa Brenner, Hermann Herrmann, Volker Holleczek, Bernd Park, Jong Y Sellers, Thomas A Lim, Hui-Yi Slavov, Chavdar Kaneva, Radka P Mitev, Vanio I Spurdle, Amanda Teixeira, Manuel R Paulo, Paula Maia, Sofia Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej PRACTICAL consortium Batra, Jyotsna Clements, Judith A Australian Prostate Cancer BioResource Albanes, Demetrius Andriole, Gerald L Berndt, Sonja I Chanock, Stephen Gapstur, Susan M Giovannucci, Edward L Hunter, David J Kraft, Peter Le Marchand, Loic Ma, Jing Mondul, Alison M Penney, Kathryn L Stampfer, Meir J Stevens, Victoria L Weinstein, Stephanie J Trichopoulou, Antonia Bueno-de-Mesquita, Bas H Tjonneland, Anne Cox, David G BPC3 consortium Maehle, Lovise Schleutker, Johanna Lindstrom, Sara Wiklund, Fredrik 14136/Cancer Research UK/United Kingdom United States Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1796-800. doi: 10.1158/1055-9965.EPI-15-0543. Epub 2015 Aug 25.",

year = "2015",

doi = "10.1158/1055-9965.EPI-15-0543",

language = "English",

volume = "24",

pages = "1796--800",

journal = "Cancer Epidemiology, Biomarkers & Prevention",

issn = "1538-7755",

publisher = "American Association for Cancer Research",

number = "11",

}

Szulkin, R, Karlsson, R, Whitington, T, Aly, M, Gronberg, H, Eeles, RA, Easton, DF, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, Southey, MC, FitzGerald, LM, Henderson, BE, Schumacher, FR, Haiman, CA, Sipeky, C, Tammela, TL, Nordestgaard, BG, Key, TJ, Travis, RC, Neal, DE, Donovan, JL, Hamdy, FC, Pharoah, PD, Pashayan, N, Khaw, KT, Stanford, JL, Thibodeau, SN, McDonnell, SK, Schaid, DJ, Maier, C, Vogel, W, Luedeke, M, Herkommer, K, Kibel, AS, Cybulski, C, Lubinski, J, Kluzniak, W, Cannon-Albright, L, Brenner, H, Herrmann, V, Holleczek, B, Park, JY, Sellers, TA, Lim, HY, Slavov, C, Kaneva, RP, Mitev, VI, Spurdle, A, Teixeira, MR, Paulo, P, Maia, S, Pandha, H, Michael, A, Kierzek, A, Batra, J, Clements, JA, Albanes, D, Andriole, GL, Berndt, SI, Chanock, S, Gapstur, SM, Giovannucci, EL, Hunter, DJ, Kraft, P, Le Marchand, L, Ma, J, Mondul, AM, Penney, KL, Stampfer, MJ, Stevens, VL, Weinstein, SJ, Trichopoulou, A, Bueno-de-Mesquita, BH, Tjonneland, A, Cox, DG, Maehle, L, Schleutker, J, Lindstrom, S & Wiklund, F 2015, 'Genome-Wide Association Study of Prostate Cancer-Specific Survival', Cancer Epidemiology, Biomarkers & Prevention, vol. 24, no. 11, pp. 1796-800. https://doi.org/10.1158/1055-9965.EPI-15-0543

TY - JOUR

T1 - Genome-Wide Association Study of Prostate Cancer-Specific Survival

AU - Szulkin, R

AU - Karlsson, R

AU - Whitington, T

AU - Aly, M

AU - Gronberg, H

AU - Eeles, R A

AU - Easton, D F

AU - Kote-Jarai, Z

AU - Al Olama, A A

AU - Benlloch, S

AU - Muir, K

AU - Giles, G G

AU - Southey, M C

AU - FitzGerald, L M

AU - Henderson, B E

AU - Schumacher, F R

AU - Haiman, C A

AU - Sipeky, C

AU - Tammela, T L

AU - Nordestgaard, B G

AU - Key, T J

AU - Travis, R C

AU - Neal, D E

AU - Donovan, J L

AU - Hamdy, F C

AU - Pharoah, P D

AU - Pashayan, N

AU - Khaw, K T

AU - Stanford, J L

AU - Thibodeau, S N

AU - McDonnell, S K

AU - Schaid, D J

AU - Maier, C

AU - Vogel, W

AU - Luedeke, M

AU - Herkommer, K

AU - Kibel, A S

AU - Cybulski, C

AU - Lubinski, J

AU - Kluzniak, W

AU - Cannon-Albright, L

AU - Brenner, H

AU - Herrmann, V

AU - Holleczek, B

AU - Park, J Y

AU - Sellers, T A

AU - Lim, H Y

AU - Slavov, C

AU - Kaneva, R P

AU - Mitev, V I

AU - Spurdle, A

AU - Teixeira, M R

AU - Paulo, P

AU - Maia, S

AU - Pandha, H

AU - Michael, A

AU - Kierzek, A

AU - Batra, J

AU - Clements, J A

AU - Albanes, D

AU - Andriole, G L

AU - Berndt, S I

AU - Chanock, S

AU - Gapstur, S M

AU - Giovannucci, E L

AU - Hunter, D J

AU - Kraft, P

AU - Le Marchand, L

AU - Ma, J

AU - Mondul, A M

AU - Penney, K L

AU - Stampfer, M J

AU - Stevens, V L

AU - Weinstein, S J

AU - Trichopoulou, A

AU - Bueno-de-Mesquita, B H

AU - Tjonneland, A

AU - Cox, D G

AU - Maehle, L

AU - Schleutker, J

AU - Lindstrom, S

AU - Wiklund, F

N1 - Szulkin, Robert Karlsson, Robert Whitington, Thomas Aly, Markus Gronberg, Henrik Eeles, Rosalind A Easton, Douglas F Kote-Jarai, Zsofia Al Olama, Ali Amin Benlloch, Sara Muir, Kenneth Giles, Graham G Southey, Melissa C FitzGerald, Liesel M Henderson, Brian E Schumacher, Fredrick R Haiman, Christopher A Sipeky, Csilla Tammela, Teuvo L J Nordestgaard, Borge G Key, Timothy J Travis, Ruth C Neal, David E Donovan, Jenny L Hamdy, Freddie C Pharoah, Paul D P Pashayan, Nora Khaw, Kay-Tee Stanford, Janet L Thibodeau, Stephen N McDonnell, Shannon K Schaid, Daniel J Maier, Christiane Vogel, Walther Luedeke, Manuel Herkommer, Kathleen Kibel, Adam S Cybulski, Cezary Lubinski, Jan Kluzniak, Wojciech Cannon-Albright, Lisa Brenner, Hermann Herrmann, Volker Holleczek, Bernd Park, Jong Y Sellers, Thomas A Lim, Hui-Yi Slavov, Chavdar Kaneva, Radka P Mitev, Vanio I Spurdle, Amanda Teixeira, Manuel R Paulo, Paula Maia, Sofia Pandha, Hardev Michael, Agnieszka Kierzek, Andrzej PRACTICAL consortium Batra, Jyotsna Clements, Judith A Australian Prostate Cancer BioResource Albanes, Demetrius Andriole, Gerald L Berndt, Sonja I Chanock, Stephen Gapstur, Susan M Giovannucci, Edward L Hunter, David J Kraft, Peter Le Marchand, Loic Ma, Jing Mondul, Alison M Penney, Kathryn L Stampfer, Meir J Stevens, Victoria L Weinstein, Stephanie J Trichopoulou, Antonia Bueno-de-Mesquita, Bas H Tjonneland, Anne Cox, David G BPC3 consortium Maehle, Lovise Schleutker, Johanna Lindstrom, Sara Wiklund, Fredrik 14136/Cancer Research UK/United Kingdom United States Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Cancer Epidemiol Biomarkers Prev. 2015 Nov;24(11):1796-800. doi: 10.1158/1055-9965.EPI-15-0543. Epub 2015 Aug 25.

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS: We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. (c)2015 AACR.

AB - BACKGROUND: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. METHODS: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). RESULTS: We observed no significant association between genetic variants and prostate cancer survival. CONCLUSIONS: Common genetic variants with large impact on prostate cancer survival were not observed in this study. IMPACT: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes. Cancer Epidemiol Biomarkers Prev; 24(11); 1796-800. (c)2015 AACR.

U2 - 10.1158/1055-9965.EPI-15-0543

DO - 10.1158/1055-9965.EPI-15-0543

M3 - Article

SN - 1538-7755

VL - 24

SP - 1796

EP - 1800

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

IS - 11

ER -

Genome-Wide Association Study of Prostate Cancer-Specific Survival

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