Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

J Cobb; E Cule; H Moncrieffe; A Hinks; S Ursu; F Patrick; L Kassoumeri; E Flynn; M Bulatović; N Wulffraat; B van Zelst; R de Jonge; M Bohm; P Dolezalova; S Hirani; S Newman; P Whitworth; T R Southwood; M De Iorio; L R Wedderburn; W Thomson

doi:10.1038/tpj.2014.3

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

J Cobb, E Cule, H Moncrieffe, A Hinks, S Ursu, F Patrick, L Kassoumeri, E Flynn, M Bulatović, N Wulffraat, B van Zelst, R de Jonge, M Bohm, P Dolezalova, S Hirani, S Newman, P Whitworth, T R Southwood, M De Iorio, L R WedderburnW Thomson

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P

Original language	English
Pages (from-to)	356-364
Number of pages	8
Journal	The pharmacogenomics journal
Volume	14
Issue number	4
DOIs	https://doi.org/10.1038/tpj.2014.3
Publication status	Published - 2014

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10.1038/tpj.2014.3

Arthritis Research UK Centre of Excellence in Epidemiology.
Symmons, D., Bruce, I., Dixon, W., Felson, D., Hyrich, K., Lunt, M., Mcbeth, J., O'Neill, T. & Verstappen, S.
1/08/13 → 31/07/18
Project: Research

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Cobb, J., Cule, E., Moncrieffe, H., Hinks, A., Ursu, S., Patrick, F., Kassoumeri, L., Flynn, E., Bulatović, M., Wulffraat, N., van Zelst, B., de Jonge, R., Bohm, M., Dolezalova, P., Hirani, S., Newman, S., Whitworth, P., Southwood, T. R., De Iorio, M., ... Thomson, W. (2014). Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. The pharmacogenomics journal, 14(4), 356-364. https://doi.org/10.1038/tpj.2014.3

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title = "Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.",

abstract = "Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P",

author = "J Cobb and E Cule and H Moncrieffe and A Hinks and S Ursu and F Patrick and L Kassoumeri and E Flynn and M Bulatovi{\'c} and N Wulffraat and {van Zelst}, B and {de Jonge}, R and M Bohm and P Dolezalova and S Hirani and S Newman and P Whitworth and Southwood, {T R} and {De Iorio}, M and Wedderburn, {L R} and W Thomson",

year = "2014",

doi = "10.1038/tpj.2014.3",

language = "English",

volume = "14",

pages = "356--364",

journal = "The pharmacogenomics journal",

issn = "1470-269X",

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Cobb, J, Cule, E, Moncrieffe, H, Hinks, A, Ursu, S, Patrick, F, Kassoumeri, L, Flynn, E, Bulatović, M, Wulffraat, N, van Zelst, B, de Jonge, R, Bohm, M, Dolezalova, P, Hirani, S, Newman, S, Whitworth, P, Southwood, TR, De Iorio, M, Wedderburn, LR & Thomson, W 2014, 'Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.', The pharmacogenomics journal, vol. 14, no. 4, pp. 356-364. https://doi.org/10.1038/tpj.2014.3

TY - JOUR

T1 - Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

AU - Cobb, J

AU - Cule, E

AU - Moncrieffe, H

AU - Hinks, A

AU - Ursu, S

AU - Patrick, F

AU - Kassoumeri, L

AU - Flynn, E

AU - Bulatović, M

AU - Wulffraat, N

AU - van Zelst, B

AU - de Jonge, R

AU - Bohm, M

AU - Dolezalova, P

AU - Hirani, S

AU - Newman, S

AU - Whitworth, P

AU - Southwood, T R

AU - De Iorio, M

AU - Wedderburn, L R

AU - Thomson, W

PY - 2014

Y1 - 2014

N2 - Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P

AB - Clinical response to methotrexate (MTX) treatment for children with juvenile idiopathic arthritis (JIA) displays considerable heterogeneity. Currently, there are no reliable predictors to identify non-responders: earlier identification could lead to a targeted treatment. We genotyped 759 JIA cases from the UK, the Netherlands and Czech Republic. Clinical variables were measured at baseline and 6 months after start of the treatment. In Phase I analysis, samples were analysed for the association with MTX response using ordinal regression of ACR-pedi categories and linear regression of change in clinical variables, and identified 31 genetic regions (P

U2 - 10.1038/tpj.2014.3

DO - 10.1038/tpj.2014.3

M3 - Article

C2 - 24709693

SN - 1470-269X

VL - 14

SP - 356

EP - 364

JO - The pharmacogenomics journal

JF - The pharmacogenomics journal

IS - 4

ER -

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

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Arthritis Research UK Centre of Excellence in Epidemiology.

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