Genome-wide patterns of histone modifications in yeast

Catherine B. Millar, Michael Grunstein

    Research output: Contribution to journalArticlepeer-review


    Post-translational histone modifications and histone variants generate complexity in chromatin to enable the many functions of the chromosome. Recent studies have mapped histone modifications across the Saccharomyces cerevisiae genome. These experiments describe how combinations of modified and unmodified states relate to each other and particularly to chromosomal landmarks that include heterochromatin, subtelomeric chromatin, centromeres, origins of replication, promoters and coding regions. Such patterns might be important for the regulation of heterochromatin-mediated silencing, chromosome segregation, DNA replication and gene expression. © 2006 Nature Publishing Group.
    Original languageEnglish
    Pages (from-to)657-666
    Number of pages9
    JournalNature Reviews Molecular Cell Biology
    Issue number9
    Publication statusPublished - 19 Sept 2006


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