TY - JOUR
T1 - Genus beta human papillomaviruses and incidence of basal cell and squamous cell carcinomas of skin: population based case-control study.
AU - Karagas, Margaret R.
AU - Waterboer, Tim
AU - Li, Zhongze
AU - Nelson, Heather H.
AU - Michael, Kristina M.
AU - Bavinck, Jan Nico Bouwes
AU - Perry, Ann E.
AU - Spencer, Steven K.
AU - Daling, Janet
AU - Green, Adele C.
AU - Pawlita, Michael
AU - New Hampshire Skin Cancer Study Group
N1 - CA118443, NCI NIH HHS, United StatesCA57494, NCI NIH HHS, United States
PY - 2010
Y1 - 2010
N2 - OBJECTIVE: To investigate the association between genus beta human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population. DESIGN: Population based case-control study. SETTING: New Hampshire, USA. PARTICIPANTS: 2366 skin cancer cases and controls from the general population aged 25 to 74 years (663 squamous cell carcinoma, 898 basal cell carcinoma, 805 controls), with plasma samples tested for L1 antibodies to 16 genus beta human papillomaviruses by multiplex serology. MAIN OUTCOME MEASURES: Odds ratios for squamous cell carcinoma and basal cell carcinoma associated with seropositivity to beta human papillomaviruses. RESULTS: Squamous cell carcinoma, but not basal cell carcinoma, cases had a higher prevalence of each of the individual beta human papillomaviruses assayed compared with controls. The odds ratios for squamous cell carcinoma increased with the number of beta types positive (odds ratio for one type positive 0.99 (95% confidence interval 0.74 to 1.33); two to three types positive 1.44 (1.03 to 2.01); four to eight types positive 1.51 (1.03 to 2.20); more than eight types positive 1.71 (1.12 to 2.62); P for trend (categorical)
AB - OBJECTIVE: To investigate the association between genus beta human papillomaviruses and the incidence of non-melanocytic skin cancer in the general population. DESIGN: Population based case-control study. SETTING: New Hampshire, USA. PARTICIPANTS: 2366 skin cancer cases and controls from the general population aged 25 to 74 years (663 squamous cell carcinoma, 898 basal cell carcinoma, 805 controls), with plasma samples tested for L1 antibodies to 16 genus beta human papillomaviruses by multiplex serology. MAIN OUTCOME MEASURES: Odds ratios for squamous cell carcinoma and basal cell carcinoma associated with seropositivity to beta human papillomaviruses. RESULTS: Squamous cell carcinoma, but not basal cell carcinoma, cases had a higher prevalence of each of the individual beta human papillomaviruses assayed compared with controls. The odds ratios for squamous cell carcinoma increased with the number of beta types positive (odds ratio for one type positive 0.99 (95% confidence interval 0.74 to 1.33); two to three types positive 1.44 (1.03 to 2.01); four to eight types positive 1.51 (1.03 to 2.20); more than eight types positive 1.71 (1.12 to 2.62); P for trend (categorical)
U2 - 10.1136/bmj.c2986
DO - 10.1136/bmj.c2986
M3 - Article
C2 - 20616098
SN - 0959-535X
VL - 341
SP - c2986
JO - Bmj
JF - Bmj
ER -
