GH deficiency status combined with GH receptor polymorphism affects response to GH in children.

Armand Valsesia; Pierre Chatelain; Adam Stevens; Valentina A Peterkova; Alicia Belgorosky; Mohamad Maghnie; Franco Antoniazzi; Ekaterina Koledova; Jerome Wojcik; Pierre Farmer; Benoit Destenaves; Peter Clayton

doi:10.1530/EJE-15-0474

GH deficiency status combined with GH receptor polymorphism affects response to GH in children.

Armand Valsesia, Pierre Chatelain, Adam Stevens, Valentina A Peterkova, Alicia Belgorosky, Mohamad Maghnie, Franco Antoniazzi, Ekaterina Koledova, Jerome Wojcik, Pierre Farmer, Benoit Destenaves, Peter Clayton

Research output: Contribution to journal › Article › peer-review

Abstract

Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n=45) and >4 to

Original language	English
Journal	European journal of endocrinology / European Federation of Endocrine Societies
Volume	173
Issue number	6
DOIs	https://doi.org/10.1530/EJE-15-0474
Publication status	Published - Dec 2015

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Valsesia, A., Chatelain, P., Stevens, A., Peterkova, V. A., Belgorosky, A., Maghnie, M., Antoniazzi, F., Koledova, E., Wojcik, J., Farmer, P., Destenaves, B., & Clayton, P. (2015). GH deficiency status combined with GH receptor polymorphism affects response to GH in children. European journal of endocrinology / European Federation of Endocrine Societies, 173(6). https://doi.org/10.1530/EJE-15-0474

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title = "GH deficiency status combined with GH receptor polymorphism affects response to GH in children.",

abstract = "Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-na{\"i}ve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n=45) and >4 to",

author = "Armand Valsesia and Pierre Chatelain and Adam Stevens and Peterkova, {Valentina A} and Alicia Belgorosky and Mohamad Maghnie and Franco Antoniazzi and Ekaterina Koledova and Jerome Wojcik and Pierre Farmer and Benoit Destenaves and Peter Clayton",

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month = dec,

doi = "10.1530/EJE-15-0474",

language = "English",

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journal = "European journal of endocrinology / European Federation of Endocrine Societies",

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publisher = "Oxford University Press",

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Valsesia, A, Chatelain, P, Stevens, A, Peterkova, VA, Belgorosky, A, Maghnie, M, Antoniazzi, F, Koledova, E, Wojcik, J, Farmer, P, Destenaves, B & Clayton, P 2015, 'GH deficiency status combined with GH receptor polymorphism affects response to GH in children.', European journal of endocrinology / European Federation of Endocrine Societies, vol. 173, no. 6. https://doi.org/10.1530/EJE-15-0474

TY - JOUR

T1 - GH deficiency status combined with GH receptor polymorphism affects response to GH in children.

AU - Valsesia, Armand

AU - Chatelain, Pierre

AU - Stevens, Adam

AU - Peterkova, Valentina A

AU - Belgorosky, Alicia

AU - Maghnie, Mohamad

AU - Antoniazzi, Franco

AU - Koledova, Ekaterina

AU - Wojcik, Jerome

AU - Farmer, Pierre

AU - Destenaves, Benoit

AU - Clayton, Peter

PY - 2015/12

Y1 - 2015/12

N2 - Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n=45) and >4 to

AB - Meta-analysis has shown a modest improvement in first-year growth response to recombinant human GH (r-hGH) for carriers of the exon 3-deleted GH receptor (GHRd3) polymorphism but with significant interstudy variability. The associations between GHRd3 and growth response to r-hGH over 3 years in relation to severity of GH deficiency (GHD) were investigated in patients from 14 countries. Treatment-naïve pre-pubertal children with GHD were enrolled from the PREDICT studies (NCT00256126 and NCT00699855), categorized by peak GH level (peak GH) during provocation test: ≤4 μg/l (severe GHD; n=45) and >4 to

U2 - 10.1530/EJE-15-0474

DO - 10.1530/EJE-15-0474

M3 - Article

C2 - 26340968

SN - 1479-683X

VL - 173

JO - European journal of endocrinology / European Federation of Endocrine Societies

JF - European journal of endocrinology / European Federation of Endocrine Societies

IS - 6

ER -

GH deficiency status combined with GH receptor polymorphism affects response to GH in children.

Abstract

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