GH/IGF-I regulation in obesity - Mechanisms and practical consequences in children and adults

Ilonka Kreitschmann-Andermahr; Pablo Suarez; Rachel Jennings; Nina Evers; Georg Brabant

doi:10.1159/000284355

GH/IGF-I regulation in obesity - Mechanisms and practical consequences in children and adults

Ilonka Kreitschmann-Andermahr, Pablo Suarez, Rachel Jennings, Nina Evers, Georg Brabant

Research output: Contribution to journal › Article › peer-review

Abstract

Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects. Copyright © 2010 S. Karger AG, Basel.

Original language	English
Pages (from-to)	153-160
Number of pages	7
Journal	Hormone research in paediatrics
Volume	73
Issue number	3
DOIs	https://doi.org/10.1159/000284355
Publication status	Published - Mar 2010

Keywords

Growth hormone
Growth hormone deficiency
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000284355

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title = "GH/IGF-I regulation in obesity - Mechanisms and practical consequences in children and adults",

abstract = "Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects. Copyright {\textcopyright} 2010 S. Karger AG, Basel.",

keywords = "Growth hormone, Growth hormone deficiency, Obesity",

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T1 - GH/IGF-I regulation in obesity - Mechanisms and practical consequences in children and adults

AU - Kreitschmann-Andermahr, Ilonka

AU - Suarez, Pablo

AU - Jennings, Rachel

AU - Evers, Nina

AU - Brabant, Georg

PY - 2010/3

Y1 - 2010/3

N2 - Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects. Copyright © 2010 S. Karger AG, Basel.

AB - Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects. Copyright © 2010 S. Karger AG, Basel.

KW - Growth hormone

KW - Growth hormone deficiency

KW - Obesity

U2 - 10.1159/000284355

DO - 10.1159/000284355

M3 - Article

C2 - 20197666

SN - 1663-2818

VL - 73

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JO - Hormone research in paediatrics

JF - Hormone research in paediatrics

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ER -

GH/IGF-I regulation in obesity - Mechanisms and practical consequences in children and adults

Abstract

Keywords

UN SDGs

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