Ghrelin does not orchestrate the metabolic changes seen in fasting but has significant effects on lipid mobilisation and substrate utilisation

M. S B Huda, T. M. Dovey, S. P. Wong, P. J. English, J. C G Halford, P. McCulloch, J. Cleator, B. Martin, J. Cashen, K. Hayden, M. A. Ghatei, S. R. Bloom, J. P H Wilding, J. H. Pinkney

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: Short-term fasting is associated with increased GH pulsatility and mobilisation of fats, but underlying mechanisms are unclear. We studied ghrelin's role during fasting and the effects of exogenous ghrelin on lipid mobilisation. Design: Randomised placebo-controlled study. Methods: In this study, ten controls (body mass index (BMI) 23.3±3.2), ten morbidly obese subjects (BMI 50.1±10.6) and six post-gastrectomy subjects (BMI 25.2±1.0) were fasted for 36 h undergoing regular blood sampling. On a separate occasion, subjects were infused with either i.v. ghrelin (5 pmol/kg per min) or saline over 270 min. Results: Obese and post-gastrectomy subjects had lower ghrelin compared with controls (ANOVA, P=0.02) during the fast. Controls and gastrectomy subjects showed a similar increase in GH pulsatility, circulating non-esterified fatty acids (NEFA) and 3β-hydroxybutyrate (3 HB). Obese subjects had an impaired GH response (P
    Original languageEnglish
    Pages (from-to)45-55
    Number of pages10
    JournalEuropean Journal of Endocrinology
    Volume165
    Issue number1
    DOIs
    Publication statusPublished - Jul 2011

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