Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects

M. S B Huda; T. Dovey; S. P. Wong; P. J. English; J. Halford; P. McCulloch; J. Cleator; B. Martin; J. Cashen; K. Hayden; J. P H Wilding; J. Pinkney

doi:10.1038/ijo.2008.270

Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects

M. S B Huda, T. Dovey, S. P. Wong, P. J. English, J. Halford, P. McCulloch, J. Cleator, B. Martin, J. Cashen, K. Hayden, J. P H Wilding, J. Pinkney

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To examine the effects of ghrelin on appetite and energy expenditure in lean, obese and postgastrectomy subjects. Design: A randomized, double-blind, placebo-controlled study. Patients: Nine lean subjects (mean body mass index (BMI) 23.5±3 kg/m2) and nine morbidly obese subjects (mean BMI 51.4±10 kg/m2) and eight postgastrectomy subjects (mean BMI 22.4±1.0 kg/m2). Interventions: Subjects were infused with either intravenous ghrelin (5 pmol kg-1 min -1) or saline over 270 min. They were given a fixed energy breakfast followed by a free buffet lunch towards the end of the infusion. Main outcome measures: Visual analogue scales were used to record hunger and energy expenditure was measured by indirect calorimetry. Results: Ghrelin increased energy intake at the buffet lunch in lean subjects (a 41% increase, P

Original language	English
Pages (from-to)	317-325
Number of pages	8
Journal	International Journal of Obesity
Volume	33
Issue number	3
DOIs	https://doi.org/10.1038/ijo.2008.270
Publication status	Published - Mar 2009

Keywords

Gastrectomy
Ghrelin
Hunger

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10.1038/ijo.2008.270

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Huda, M. S. B., Dovey, T., Wong, S. P., English, P. J., Halford, J., McCulloch, P., Cleator, J., Martin, B., Cashen, J., Hayden, K., Wilding, J. P. H., & Pinkney, J. (2009). Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects. International Journal of Obesity, 33(3), 317-325. https://doi.org/10.1038/ijo.2008.270

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title = "Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects",

abstract = "Objective: To examine the effects of ghrelin on appetite and energy expenditure in lean, obese and postgastrectomy subjects. Design: A randomized, double-blind, placebo-controlled study. Patients: Nine lean subjects (mean body mass index (BMI) 23.5±3 kg/m2) and nine morbidly obese subjects (mean BMI 51.4±10 kg/m2) and eight postgastrectomy subjects (mean BMI 22.4±1.0 kg/m2). Interventions: Subjects were infused with either intravenous ghrelin (5 pmol kg-1 min -1) or saline over 270 min. They were given a fixed energy breakfast followed by a free buffet lunch towards the end of the infusion. Main outcome measures: Visual analogue scales were used to record hunger and energy expenditure was measured by indirect calorimetry. Results: Ghrelin increased energy intake at the buffet lunch in lean subjects (a 41% increase, P",

keywords = "Gastrectomy, Ghrelin, Hunger",

author = "Huda, {M. S B} and T. Dovey and Wong, {S. P.} and English, {P. J.} and J. Halford and P. McCulloch and J. Cleator and B. Martin and J. Cashen and K. Hayden and Wilding, {J. P H} and J. Pinkney",

year = "2009",

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Huda, MSB, Dovey, T, Wong, SP, English, PJ, Halford, J, McCulloch, P, Cleator, J, Martin, B, Cashen, J, Hayden, K, Wilding, JPH & Pinkney, J 2009, 'Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects', International Journal of Obesity, vol. 33, no. 3, pp. 317-325. https://doi.org/10.1038/ijo.2008.270

TY - JOUR

T1 - Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects

AU - Huda, M. S B

AU - Dovey, T.

AU - Wong, S. P.

AU - English, P. J.

AU - Halford, J.

AU - McCulloch, P.

AU - Cleator, J.

AU - Martin, B.

AU - Cashen, J.

AU - Hayden, K.

AU - Wilding, J. P H

AU - Pinkney, J.

PY - 2009/3

Y1 - 2009/3

N2 - Objective: To examine the effects of ghrelin on appetite and energy expenditure in lean, obese and postgastrectomy subjects. Design: A randomized, double-blind, placebo-controlled study. Patients: Nine lean subjects (mean body mass index (BMI) 23.5±3 kg/m2) and nine morbidly obese subjects (mean BMI 51.4±10 kg/m2) and eight postgastrectomy subjects (mean BMI 22.4±1.0 kg/m2). Interventions: Subjects were infused with either intravenous ghrelin (5 pmol kg-1 min -1) or saline over 270 min. They were given a fixed energy breakfast followed by a free buffet lunch towards the end of the infusion. Main outcome measures: Visual analogue scales were used to record hunger and energy expenditure was measured by indirect calorimetry. Results: Ghrelin increased energy intake at the buffet lunch in lean subjects (a 41% increase, P

AB - Objective: To examine the effects of ghrelin on appetite and energy expenditure in lean, obese and postgastrectomy subjects. Design: A randomized, double-blind, placebo-controlled study. Patients: Nine lean subjects (mean body mass index (BMI) 23.5±3 kg/m2) and nine morbidly obese subjects (mean BMI 51.4±10 kg/m2) and eight postgastrectomy subjects (mean BMI 22.4±1.0 kg/m2). Interventions: Subjects were infused with either intravenous ghrelin (5 pmol kg-1 min -1) or saline over 270 min. They were given a fixed energy breakfast followed by a free buffet lunch towards the end of the infusion. Main outcome measures: Visual analogue scales were used to record hunger and energy expenditure was measured by indirect calorimetry. Results: Ghrelin increased energy intake at the buffet lunch in lean subjects (a 41% increase, P

KW - Gastrectomy

KW - Ghrelin

KW - Hunger

U2 - 10.1038/ijo.2008.270

DO - 10.1038/ijo.2008.270

M3 - Article

SN - 1476-5497

VL - 33

SP - 317

EP - 325

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 3

ER -

Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects

Abstract

Keywords

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