Giving off mixed signals - Distinct functions of α5β 1 and αvβ3 integrins in regulating cell behaviour

Mark R. Morgan, Adam Byron, Martin J. Humphries, Mark D. Bass

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ 3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB.
    Original languageEnglish
    Pages (from-to)731-738
    Number of pages7
    JournalIUBMB Life
    Volume61
    Issue number7
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Endocytosis
    • Focal adhesion
    • Integrin
    • Migration
    • Signalling
    • Trafficking

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