Giving off mixed signals - Distinct functions of α5β 1 and αvβ3 integrins in regulating cell behaviour

Mark R. Morgan; Adam Byron; Martin J. Humphries; Mark D. Bass

doi:10.1002/iub.200

Giving off mixed signals - Distinct functions of α5β 1 and αvβ3 integrins in regulating cell behaviour

Mark R. Morgan, Adam Byron, Martin J. Humphries, Mark D. Bass

Research output: Contribution to journal › Article › peer-review

Abstract

The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ 3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB.

Original language	English
Pages (from-to)	731-738
Number of pages	7
Journal	IUBMB Life
Volume	61
Issue number	7
DOIs	https://doi.org/10.1002/iub.200
Publication status	Published - 2009

Keywords

Endocytosis
Focal adhesion
Integrin
Migration
Signalling
Trafficking

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10.1002/iub.200

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title = "Giving off mixed signals - Distinct functions of α5β 1 and αvβ3 integrins in regulating cell behaviour",

abstract = "The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ 3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. {\textcopyright} 2009 IUBMB.",

keywords = "Endocytosis, Focal adhesion, Integrin, Migration, Signalling, Trafficking",

author = "Morgan, {Mark R.} and Adam Byron and Humphries, {Martin J.} and Bass, {Mark D.}",

note = "The authors were supported by Wellcome Trust grant 074941 (M.R.M., M.D.B., and M.J.H.) and by a Biotechnology and Biological Sciences Research Council Collaborative Awards in Science and Engineering PhD studentship, sponsored by GlaxoSmithKline (A.B.).",

year = "2009",

doi = "10.1002/iub.200",

language = "English",

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pages = "731--738",

journal = "IUBMB Life",

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TY - JOUR

T1 - Giving off mixed signals - Distinct functions of α5β 1 and αvβ3 integrins in regulating cell behaviour

AU - Morgan, Mark R.

AU - Byron, Adam

AU - Humphries, Martin J.

AU - Bass, Mark D.

N1 - The authors were supported by Wellcome Trust grant 074941 (M.R.M., M.D.B., and M.J.H.) and by a Biotechnology and Biological Sciences Research Council Collaborative Awards in Science and Engineering PhD studentship, sponsored by GlaxoSmithKline (A.B.).

PY - 2009

Y1 - 2009

N2 - The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ 3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB.

AB - The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ 3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB.

KW - Endocytosis

KW - Focal adhesion

KW - Integrin

KW - Migration

KW - Signalling

KW - Trafficking

U2 - 10.1002/iub.200

DO - 10.1002/iub.200

M3 - Article

C2 - 19514020

VL - 61

SP - 731

EP - 738

JO - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 7

ER -

Giving off mixed signals - Distinct functions of α5β 1 and αvβ3 integrins in regulating cell behaviour

Abstract

Keywords

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