Glia in the pathogenesis of neurodegenerative diseases

Alexei Verkhratsky, Vladimir Parpura, Marcela Pekna, Milos Pekny, Michael Sofroniew

    Research output: Contribution to journalArticlepeer-review

    Abstract

    ©The Authors Journal compilation ©2014 Biochemical Society.Exclusively neuron-centric approaches to neuropathological mechanisms have not resulted in major new breakthroughs in the prevention and therapy of neurodegenerative diseases. In the present paper,we review the role of glia in neurodegeneration in an attempt to identify novel targets that could be used to develop much-needed strategies for the containment and cure of neurodegenerative disorders. We discuss this in the context of glial roles in the homoeostasis and defence of the brain. We consider the mounting evidence supporting a change away from the perception of reactive glial responses merely as secondary detrimental processes that exacerbate the course of neurological disorders, in favour of an emerging contemporary view of glial pathological responses as complex and multistaged defensive processes that also have the potential for dysfunction.
    Original languageEnglish
    Pages (from-to)1291-1301
    Number of pages10
    JournalBiochemical Society Transactions
    Volume42
    Issue number5
    DOIs
    Publication statusPublished - 1 Oct 2014

    Keywords

    • Alzheimer's disease
    • Amyotrophic lateral sclerosis
    • Glia
    • Huntington's disease
    • Neurodegeneration
    • Parkinson's disease

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