Glioblastoma: New Molecular Concepts Pave the Way for Advances in Diagnosis and Treatment

Mairead Mcnamara, S Brandner, SC Thust

Research output: Book/ReportBook

Abstract

Glioblastoma (also known as glioblastoma multiforme), a type of
glioma, is a high-grade brain tumor that develops from the glial cells
surrounding neurons. It is the most common aggressive intrinsic brain
tumor in adults, with the potential to spread rapidly within the brain.
Patients with glioblastoma face a poor prognosis, with median overall
survival of approximately 15 months. However, our growing
understanding of the molecular biology of gliomas means that this
outlook may be improving.
The identification of clinically relevant subgroups defined by
specific genetic mutations is challenging the traditional delineation
between low- and high-grade gliomas that has been based on
histological appearance and imaging. Indeed, it is becoming clear that,
as a molecular entity, a glioblastoma, which by traditional
classification is a grade IV glioma, may present with a lower grade
initially and then become more aggressive – an important addition to
the established concept.
The care of a patient with a glioblastoma requires a coordinated
approach delivered by a multidisciplinary team, with the aim of
maintaining quality of life for as long as possible. Here, we provide a
concise overview of the diagnosis and management of glioblastoma, as
well as discussion of our emerging understanding of the molecular
drivers that are helping us to delineate different patient subgroups.
These subgroups will, hopefully, allow more targeted treatments in
the future.
This resource will be of interest to all those involved in caring for
patients with this aggressive brain tumor, including neurologists,
neurosurgeons, neuro-oncologists, radiation oncologists, palliative
care specialists, specialist nurses and medical students.

Original languageEnglish
PublisherS. Karger AG
ISBN (Print)9781912776702
Publication statusPublished - 2020

Publication series

NameFast Facts

Keywords

  • Glioblastoma
  • Pathology
  • Radiology
  • Treatment

Research Beacons, Institutes and Platforms

  • Manchester Cancer Research Centre

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