Global air pollutant, phenanthrene, and arrhythmic outcomes in a mouse model

Sana Yaar, TS Filatova , Ellie England, Shiva Nag Kompella, JC Hancox, David Bechtold, Luigi Venetucci, DV Abramochkin , Holly Shiels

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The 3-ringed polycyclic aromatic hydrocarbon (PAH) phenanthrene (Phe), has been implicated in the cardiotoxicity of petroleum-based pollution in aquatic systems, where it disrupts the contractile and electrical function of the fish heart. Phe is also found adsorbed to particulate matter (PM) and in the gas phase of air pollution, but to date, no studies have investigated the impact of Phe on mammalian cardiac function.
Original languageEnglish
JournalEnvironmental Health Perspectives
Publication statusAccepted/In press - 25 Sept 2023

Keywords

  • Air pollution
  • polycyclic aromatic hydrocarbons
  • PAH
  • heart
  • cardiomyocytes
  • cardiotoxicity
  • electrophysiology

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