Glucose neurotoxicity

David R. Tomlinson; Natalie J. Gardiner

doi:10.1038/nrn2294

Glucose neurotoxicity

Research output: Contribution to journal › Article › peer-review

Abstract

Neurons have a constantly high glucose demand, and unlike muscle cells they cannot accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake depends on the extracellular concentration of glucose, and cellular damage can ensue after persistent episodes of hyperglycaemia - a phenomenon referred to as glucose neurotoxicity. This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy. © 2008 Nature Publishing Group.

Original language	English
Pages (from-to)	36-45
Number of pages	9
Journal	Nature Reviews. Neuroscience
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/nrn2294
Publication status	Published - Jan 2008

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10.1038/nrn2294

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title = "Glucose neurotoxicity",

abstract = "Neurons have a constantly high glucose demand, and unlike muscle cells they cannot accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake depends on the extracellular concentration of glucose, and cellular damage can ensue after persistent episodes of hyperglycaemia - a phenomenon referred to as glucose neurotoxicity. This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy. {\textcopyright} 2008 Nature Publishing Group.",

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AB - Neurons have a constantly high glucose demand, and unlike muscle cells they cannot accommodate episodic glucose uptake under the influence of insulin. Neuronal glucose uptake depends on the extracellular concentration of glucose, and cellular damage can ensue after persistent episodes of hyperglycaemia - a phenomenon referred to as glucose neurotoxicity. This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy. © 2008 Nature Publishing Group.

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Glucose neurotoxicity

Abstract

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