Glucose-oxidase based self-destructing polymeric vesicles

Alessandro Napoli, Mark J. Boerakker, Nicola Tirelli, Roeland J M Nolte, Nico A J M Sommerdijk, Jeffrey A. Hubbell

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have designed oxidation-responsive vesicles from synthetic amphiphilic block copolymers ("polymersomes") of ethylene glycol and propylene sulfide. Thioethers in the hydrophobic poly(propylene sulfide) block are converted into the more hydrophilic sulfoxides and sulfones upon exposure to an oxidatiye environment, changing the hydrophilic-lipophilic balance of the macroamphiphile and thus inducing its solubilization. Here we sought to explore generation of the oxidative environment and induction of polymersome destabilization through production of hydrogen peroxide by the glucose-oxidase (GOx)/glucose/oxygen system. We studied the encapsulation of GOx within polymersomes, its stability and activity, and glucose-triggered polymersome destabilization. Stimulus-responsive polymersomes may find applications as nanocontainers in sensing devices and as drug delivery systems.
    Original languageEnglish
    Pages (from-to)3487-3491
    Number of pages4
    JournalLangmuir
    Volume20
    Issue number9
    DOIs
    Publication statusPublished - 27 Apr 2004

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