Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

J. Bentley; I. Walker; E. McIntosh; A. D. Whetton; P. J. Owen-Lynch; S. A. Baldwin

doi:10.1046/j.1365-2141.2001.02428.x

Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

J. Bentley, I. Walker, E. McIntosh, A. D. Whetton, P. J. Owen-Lynch, S. A. Baldwin

Research output: Contribution to journal › Article › peer-review

Abstract

The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr-Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upregulation of glucose transport was mediated by phosphatidylinositol-3kinase. The observation that Bcr-Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.

Original language	English
Pages (from-to)	212-215
Number of pages	3
Journal	British Journal of Haematology
Volume	112
Issue number	1
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02428.x
Publication status	Published - 2001

Keywords

Bcr-Abl
CML
Glucose transport
Multipotent stem cells
PI3-kinase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1046/j.1365-2141.2001.02428.x

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title = "Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model",

abstract = "The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr-Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upregulation of glucose transport was mediated by phosphatidylinositol-3kinase. The observation that Bcr-Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.",

keywords = "Bcr-Abl, CML, Glucose transport, Multipotent stem cells, PI3-kinase",

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T1 - Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

AU - Bentley, J.

AU - Walker, I.

AU - McIntosh, E.

AU - Whetton, A. D.

AU - Owen-Lynch, P. J.

AU - Baldwin, S. A.

PY - 2001

Y1 - 2001

N2 - The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr-Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upregulation of glucose transport was mediated by phosphatidylinositol-3kinase. The observation that Bcr-Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.

AB - The regulation of nutrient transport by both cytokines and oncogenes has been linked to haemopoietic cell survival. In this study, we found that activation of Bcr-Abl protein tyrosine kinase was associated with the stimulation of glucose transport in the multipotent haemopoietic cell line FDCP-mix, a cell model for chronic-phase chronic myeloid leukaemia (CML). Bcr-Abl upregulation of glucose transport was mediated by phosphatidylinositol-3kinase. The observation that Bcr-Abl can regulate glucose transport in a CML cell model raises the possibility that glucose transport regulation may have a role to play in the aberrant survival of stem cells in the chronic phase of CML.

KW - Bcr-Abl

KW - CML

KW - Glucose transport

KW - Multipotent stem cells

KW - PI3-kinase

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DO - 10.1046/j.1365-2141.2001.02428.x

M3 - Article

SN - 0007-1048

VL - 112

SP - 212

EP - 215

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -

Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model

Abstract

Keywords

UN SDGs

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