TY - JOUR
T1 - Glycaemia but not the Metabolic Syndrome is Associated with Cognitive Decline
T2 - Findings From the European Male Ageing Study
AU - Overman, Margot J
AU - Pendleton, Neil
AU - O'Neill, Terence
AU - Bartfai, Gyorgy
AU - Casanueva, Felipe
AU - Forti, Gianni
AU - Rastrelli, Giulia
AU - Giwercman, Aleksander
AU - Han, Thang S
AU - Huhtaniemi, Ilpo T.
AU - Kula, Krzysztof
AU - Lean, Michael E J
AU - Punab, Margus
AU - Lee, David
AU - Correa, Elon S
AU - Ahern, Tomas
AU - Laurent, Michaël R
AU - Verschueren, Sabine
AU - Antonio, Leen
AU - Gielen, Evelien
AU - Rutter, Martin
AU - Vanderschueren, Dirk
AU - Wu, Frederick
AU - Tournoy, Jos
AU - The EMAS Study Group
PY - 2017
Y1 - 2017
N2 - Objectives
Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal study, we aimed to investigate whether MetS or its components affect cognitive decline in ageing men and whether any interaction with inflammation existed.
Design
Longitudinal study over a mean of 4.4 (SD ± 0.3) years.
Setting
Multi-centre European male Ageing Study (EMAS).
Participants
Men aged 40-79 years.
Measurements
Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay.
Results
Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models, the presence of baseline MetS was not associated with cognitive decline over time (p>0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β=-0.42, p<0.05) and the DSST (β=-0.39, p<0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline.
Conclusions
We found no evidence for a relationship between MetS or inflammation and cognitive decline in this sample of ageing men. However, glycaemia was negatively associated with visuo-constructional abilities and processing speed.
AB - Objectives
Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycaemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. In this longitudinal study, we aimed to investigate whether MetS or its components affect cognitive decline in ageing men and whether any interaction with inflammation existed.
Design
Longitudinal study over a mean of 4.4 (SD ± 0.3) years.
Setting
Multi-centre European male Ageing Study (EMAS).
Participants
Men aged 40-79 years.
Measurements
Cognitive functioning was assessed using the Rey-Osterrieth Complex Figure (ROCF), the Camden Topographical Recognition Memory (CTRM) task, and the Digit Symbol Substitution Test (DSST). High-sensitivity C-reactive protein (hs-CRP) levels were measured using a chemiluminescent immunometric assay.
Results
Overall, 1,913 participants contributed data to the ROCF analyses and 1,965 subjects contributed to the CTRM and DSST analyses. In multiple regression models, the presence of baseline MetS was not associated with cognitive decline over time (p>0.05). However, logistic ordinal regressions indicated that high glucose levels were related to a greater risk of decline on the ROCF Copy (β=-0.42, p<0.05) and the DSST (β=-0.39, p<0.001). There was neither a main effect of hs-CRP levels nor an interaction effect of hs-CRP and MetS at baseline on cognitive decline.
Conclusions
We found no evidence for a relationship between MetS or inflammation and cognitive decline in this sample of ageing men. However, glycaemia was negatively associated with visuo-constructional abilities and processing speed.
U2 - 10.1016/j.jagp.2017.02.004
DO - 10.1016/j.jagp.2017.02.004
M3 - Article
SN - 1064-7481
VL - 25
SP - 662
EP - 671
JO - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
IS - 6
ER -