Glycated LDL (GLYC-LDL) promotes osteogenic differentiation of vascular smooth muscle cells

Ria Weston; Fiona Wilkinson; Yifen Liu; Jonathan Schofield; Tarza Siahmansur; Handrean Soran; Yvonne Alexander

doi:10.1136/heartjnl-2015-308066.214

Glycated LDL (GLYC-LDL) promotes osteogenic differentiation of vascular smooth muscle cells

Ria Weston, Fiona Wilkinson, Yifen Liu, Jonathan Schofield, Tarza Siahmansur, Handrean Soran, Yvonne Alexander

Division of Diabetes, Endocrinology & Gastroenterology

Research output: Contribution to journal › Article › peer-review

Abstract

It is well established that glyc-LDL is elevated in the serum of diabetic patients compared to healthy subjects, and that vascular calcification is common in diabetes. Furthermore, recent studies suggest that advanced glycation end products may play a pathogenic role in vascular calcification. We hypothesise that glyc-LDL promotes the osteogenic differentiation of vascular smooth muscle cells in vitro.

Original language	English
Pages (from-to)	A117-A117
Journal	Heart
Volume	101
Issue number	Suppl 4
DOIs	https://doi.org/10.1136/heartjnl-2015-308066.214
Publication status	Published - Jun 2015

Access to Document

10.1136/heartjnl-2015-308066.214

Cite this

@article{835ae2977f2a456390dce407202162a8,

title = "Glycated LDL (GLYC-LDL) promotes osteogenic differentiation of vascular smooth muscle cells",

abstract = " It is well established that glyc-LDL is elevated in the serum of diabetic patients compared to healthy subjects, and that vascular calcification is common in diabetes. Furthermore, recent studies suggest that advanced glycation end products may play a pathogenic role in vascular calcification. We hypothesise that glyc-LDL promotes the osteogenic differentiation of vascular smooth muscle cells in vitro.",

author = "Ria Weston and Fiona Wilkinson and Yifen Liu and Jonathan Schofield and Tarza Siahmansur and Handrean Soran and Yvonne Alexander",

year = "2015",

month = jun,

doi = "10.1136/heartjnl-2015-308066.214",

language = "English",

volume = "101",

pages = "A117--A117",

journal = "Heart",

issn = "1355-6037",

publisher = "BMJ ",

number = "Suppl 4",

}

TY - JOUR

T1 - Glycated LDL (GLYC-LDL) promotes osteogenic differentiation of vascular smooth muscle cells

AU - Weston, Ria

AU - Wilkinson, Fiona

AU - Liu, Yifen

AU - Schofield, Jonathan

AU - Siahmansur, Tarza

AU - Soran, Handrean

AU - Alexander, Yvonne

PY - 2015/6

Y1 - 2015/6

N2 - It is well established that glyc-LDL is elevated in the serum of diabetic patients compared to healthy subjects, and that vascular calcification is common in diabetes. Furthermore, recent studies suggest that advanced glycation end products may play a pathogenic role in vascular calcification. We hypothesise that glyc-LDL promotes the osteogenic differentiation of vascular smooth muscle cells in vitro.

AB - It is well established that glyc-LDL is elevated in the serum of diabetic patients compared to healthy subjects, and that vascular calcification is common in diabetes. Furthermore, recent studies suggest that advanced glycation end products may play a pathogenic role in vascular calcification. We hypothesise that glyc-LDL promotes the osteogenic differentiation of vascular smooth muscle cells in vitro.

U2 - 10.1136/heartjnl-2015-308066.214

DO - 10.1136/heartjnl-2015-308066.214

M3 - Article

SN - 1355-6037

VL - 101

SP - A117-A117

JO - Heart

JF - Heart

IS - Suppl 4

ER -

Glycated LDL (GLYC-LDL) promotes osteogenic differentiation of vascular smooth muscle cells

Abstract

Access to Document

Fingerprint

Cite this